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B. Åstedt B. Bladh L. Holmberg P. Liedholm 《Cellular and molecular life sciences : CMLS》1976,32(2):148-149
Summary Human seminal plasma contains an activator of plasminogen which was chromatographically purified. The molecular weight was determined to be 67,000.This study was supported by grants from the Swedish Medical Research Council (No. B75-17X-4523-01). 相似文献
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A. Smokovitis 《Cellular and molecular life sciences : CMLS》1979,35(6):776-777
Summary Blood vessels isolated from the liver of the rat, guinea-pig, rabbit, dog and pig showed histochemically a more or less high plasminogen activator activity. In whole liver sections, the abundant release and diffusion of inhibitors of fibrinolysis from the liver parenchyma during the histochemical procedure, partially or totally mask this high vascular activity. 相似文献
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A Smokovitis 《Experientia》1979,35(6):776-777
Blood vessels isolated from the liver of the rat, guinea-pig, rabbit, dog and pig showed histochemically a more or less high plasminogen activator activity. In whole liver sections, the abundant release and diffusion of inhibitors of fibrinolysis from the liver parenchyma during the histochemical procedure, partially or totally mask this high vascular activity. 相似文献
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An extractive fibrinolytic enzyme has been characterized and found to belong to the class of vascular plasminogen activators. The agent has been found to have an antithrombotic action in the rabbit. 相似文献
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D. Bergqvist I. M. Nilsson M. Pandolfi 《Cellular and molecular life sciences : CMLS》1984,40(1):67-68
Summary An extractive fibrinolytic enzyme has been characterized and found to belong to the class of vascular plasminogen activators. The agent has been found to have an antithrombotic action in the rabbit.Provided by Dr L. Dussourd d'Hinterland, Laboratoires Pierre Fabre, Castres, France. 1000 units have a fibrinolytic activity of about 15 PU urokinase. 相似文献
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The plasminogen activator system: biology and regulation 总被引:29,自引:0,他引:29
Irigoyen JP Muñoz-Cánoves P Montero L Koziczak M Nagamine Y 《Cellular and molecular life sciences : CMLS》1999,56(1-2):104-132
The regulation of plasminogen activation involves genes for two plasminogen activators (tissue type and urokinase type),
two specific inhibitors (type 1 and type 2), and a membrane-anchored urokinase-type plasminogen-activator-specific receptor.
This system plays an important role in various biological processes involving extracellular proteolysis. Recent studies have
revealed that the system, through interplay with integrins and the extracellular matrix protein vitronectin, is also involved
in the regulation of cell migration and proliferation in a manner independent of proteolytic activity. The genes are expressed
in many different cell types and their expression is under the control of diverse extracellular signals. Gene expression reflects
the levels of the corresponding mRNA, which should be the net result of synthesis and degradation. Thus, modulation of mRNA
stability is an important factor in overall regulation. This review summarizes current understanding of the biology and regulation
of genes involved in plasminogen activation at different levels.
Received 21 December 1998; received after revision 8 March 1999; accepted 14 April 1999 相似文献
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Plasminogen activator, secreted by metastatic tumor cells, was strongly inhibited in buffer or tissue culture medium containing physiological concentrations of NaCl. Intact cells, however, expressed strong activity under similar conditions. Thus, if plasminogen activator is involved in invasion and metastasis, the cellular activity, acting as an ectoenzyme, may be more important than secreted enzyme under physiological conditions. 相似文献
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Summary In the medium of endometrial carcinoma cultures, anti-urokinase-reacting plasminogen activator was released in contrast to cultures of normal or hyperplastic endometrium.This investigation was supported by grants from Malmö General Hospital, the Council for Tobacco Research, USA and the Swedish Medical Research Council (B79-17X-04523-05B). 相似文献
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In the medium of endometrial carcinoma cultures, anti-urokinase-reacting plasminogen activator was released in contrast to cultures of normal or hyperplastic endometrium. 相似文献
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Barbara Wünschmann-Henderson T. Astrup 《Cellular and molecular life sciences : CMLS》1978,34(10):1288-1289
Summary The production of tissue plasminogen activator (TPA) in rat tongue organ cultures is strongly inhibited by low concentrations of the protein synthesis inhibitor cycloheximide. TPA production is fully resumed after the removal of cycloheximide from the culture medium.This study was supported by a USPHS grant (HE-05050) from the National Heart and Lung Institute. 相似文献
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Résumé On a constaté que la production et la sécrétion de l'activateur du plasminogéne a lieu pendant la perfusion des reins du lapin à l'aide d'une suspension d'érythrocytes oxygenés. 相似文献
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Three cultured human cell lines, renal cancer cells (ACHN), bladder cancer cells (EJ), and fibroblasts transformed in culture by Co-60 gamma rays (KMST-6), when treated with interferon-beta, produced 1.5 to 4 times as much plasminogen activator as the untreated control cultures. This enhanced production of PA was inhibited by cycloheximide or actinomycin D. 相似文献
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P. Badenoch-Jones I. A. Ramshaw A. Grant 《Cellular and molecular life sciences : CMLS》1986,42(4):433-435
Summary Plasminogen activator, secreted by metastatic tumor cells, was strongly inhibited in buffer or tissue culture medium containing physiological concentrations of NaCl. Intact cells, however, expressed strong activity under similar conditions. Thus, if plasminogen activator is involved in invasion and metastasis, the cellular activity, acting as an ectoenzyme, may be more important than secreted enzyme under physiological conditions. 相似文献
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Summary The anabolic steroid stanozolol administered orally in male Sprague-Dawley rats induced a dose- and time-dependent increase in tissue plasminogen activator activity. The increase was highest in lung, lowest in heart, and intermediate in aorta and kidney. A slight increase in plasmin inhibition was noted only in the heart.This study was partially supported by a grant from the Atherosclerosis and Thrombosis Research Committee of the Austrian Academy of Sciences. 相似文献
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J M Blindermann M Ma?tre L Ossola P Mandel 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,285(10):1079-1082
A method of purifying the glutamate decarboxylase from human brain is described. The enzyme was purified 8 000 fold in regard to the initial homogenate and appears homogenous by electrophoresis, both in denaturing and non-denaturing conditions. The molecular weight of the native enzyme and its subunits indicate that GAD from human brain is formed by two similar if non identical polypeptide chains. The Km for glutamate and pyridoxal phosphate found for the human enzyme, respectively 1,2.10(-3) M and 0,13.10(-6) M, are close to the Km found for the Mouse enzyme. 相似文献