Hemmung der Corticosteroid-11Β-hydroxylierung durch einen Extrakt aus corpus pineale

Summary A hexane extract of bovine pineal glands reduced the production of 11-OH-corticosteroids and augmented the formation of 11-desoxycorticosteroids in slices of bovine adrenal cortex. It is suggested, therefore, that bovine pineal glands contain one or several substances which inhibit the 11-hydroxylation of corticosteroids.     

Hemmung der durch Proteuslipopolysaccharide gesteigerten Leukozytenemigration in vitro durch antiinflammatorische Corticosteroide

Summary The migration of leucocytes from the buffy coat of chicken blood is slightly but irregulatly inhibited by cortison. If migration of leucocytes is increased by proteus lipopolysaccharide, cortison in concentrations of 10^–4–10^–6, and other anti-inflammatory steroids, produce a pronounced and constant inhibition of leucocytic migration.     

Erzeugung von Rigor der Rattenxtremitäten durch Hemmung der Glyzin-Synthese

Summary Inhibition of glycine synthesis by aminopterine, an antagonist of pteroilglutaminic acid, causes rigidity of hind limbs in rats. This rigidity can be abolished by the injection of glycine.     

Die Hemmung von Enzymen der Inneren Mitochondrienmembran durch Benzbromaron

Summary The uricosuric drug benzbromarone inhibits a number of membrane-bound mitochondrial enzymes. A strong inhibition of succinate dehydrogenase, -glycerophosphate dehydrogenase and pyridinnucleotide transhydrogenase was found (approximately 28, 48, 45 M benzbromarone for 50% inhibition respectively). Some possible consequences of these results for the lipid metabolism in patients during benzbromarone are discussed.     

Hemmung der experimentellen,testosteron-bedingten Epidermisproliferation an der weiblichen Ratte durch ein synthetisches Phenanthrenderivat mit antiandrogener Wirkung

Summary In the female rat, testosterone propionate-induced proliferation of the epidermis (acanthosis and mitotic activation) is inhibited in proportion to dosage by a phenanthrene derivative with antiandrogenic action.     

Hemmung von SH-Enzymen durch Ethacrynsäure

Summary Enzymes with essential SH-groups (succinate dehydrogenase, proline oxidase, glycerinaldehyde-3-phosphate dehydrogenase) are inhibited by ethacrynic acid. The concentrations needed are comparable with those known to inhibit energy-linked reactions in mitochondria. It is suggested that the action of ethycrynic acid is not only due to its influence on mitochondrial energy conserving reactions.     

Hemmung von Morphin-Effekten durch synthetische Substanz P

Summary Synthetic Substance P and naloxone abolish the proconvulsive action of morphine on pentetrasol-induced seizures. It is suggested that Substance P could be a natural antagonist of morphine in the central nervous system.

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Am 20. März 1976 gestorben.     

Hemmung des durch blutdrucksenkende Pharmaka bei Ratten ausgelösten Trinkens durch Nephrektomie

Summary The drinking response of rats seen after the hypotensive drugs phentolamine, isoproterenol and hydralazine/bretylium can be abolished by nephrectomy. It is postulated, that the dipsogenic activity of these drugs is mediated by renin.     

Über die Hemmung des Gerinnungsfermentes Thrombin durch Benzamidinderivate

Summary A series of aminomethyl, guanidino and amidino derivatives of benzene were investigated for their inhibitory effect on the activity of thrombin. Amidines were generally more potent than the other compounds.p-Amidinophenylpyruvic acid, a strong trypsin inhibitor, was found also to be the strongest small-molecular inhibitor on the activity of thrombin.     

Hemmung der Azetylierungsfunktion des Coenzyms A

Summary It is demonstrated that the acetylation of sulfanilamide and of p-amino-azobenzene, in the presence of pigeon liver extract and coenzyme A, is not only inhibited by -phenyl fatty acids but also by a considerable number of other substances. The most effective inhibitors contain at least two benzene nuclei and one acidic group (phenolic hydroxyl or a carboxyl group).     

Steigerung der14CO2-Bildung aus14C-Glukose bei der Ratte durch das orale Antidiabetikum Butylbiguanid-hydrochlorid

Summary Comparative investigations were carried out in rats to determine the effect of butylbiguanide and of insulin on the oxidation of uniform¹⁴C-labelled glucose. The administration of equally hypoglycaemic active doses of butylbiguanide (250 mg per kg orally) or of insulin (2 IU s.c.), together with 0.1 µC¹⁴C-glucose, caused similar increases in the elimination rate of¹⁴CO₂.

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Die Ergebnisse wurden auszugsweise vorgetragen anlässlich der 4. Tagung der Europäischen Gesellschaft für Diabetologie, Löwen 1968.     

Hemmung der Kininbildung im Blut durchp-Amidinophenylbrenztraubensäure

Summary The serum kallikrein-induced kinin liberation in the blood is inhibited by amidino phenyl pyruvic acid (APPA) in vitro and in vivo.     

Über die Beeinflussung der Ca-Aufnahme in Lipidextrakte aus Mikrosomen und Mitochondrien des Herzens durch Digitoxin

Summary Lipids were isolated by chloroform-methanol extraction from mitochondrial and microsomal fractions of guinea-pig hearts. In the presence of digitoxin (10^–9-10^–6 g/ml) 15–30% more radioactive Ca was taken up by the lipid extracts than under control conditions, but the total amount of Ca in this phase remained unchanged. Thus, digitoxin produced an increase in the specific activity of the lipid-bound Ca which may be explained by an increased exchangeability of this Ca fraction. This effect of digitoxin might result in an improved availability of the lipid-bound Ca for Ca-dependent functions (e.g. contraction) of the heart muscle cell.     

Sexchromatinbestimmung aus der Haarwurzel

Summary A method is described by which sex chromatin can be easily and routinely determined in the cell nuclei of the root sheath of a single pulled human hair.     

Die Beeinflussung der Mitose durch Urethan

Summary 2% aqueous solution of urethan causes after 6–10 hours' action on root types ofVicia faba andAllium cepa a shortening of chromosomes, it stops also the metaphase and lowers the rate of mitosis. Probably there is a connection between the lipophile groups, the reduction in surface tension, and the diminution of chromosomes. Dioxan with similar physical properties has the same effect.     

Peroxidase-Isoenzyme in Kressekeimlingen (Lepidium sativum L.) und ihre Hemmung durch Silybin,Silydianin und Silychristin

Summary Seedlings ofLepidium sativum L. contain 4 peroxidase isoenzymes. Their de-novo-synthesis is significantly depressed in the presence of 3·10^–3 moles/l silybin, silydianin and silychristin in the incubation medium respectively.     

Hemmung der cancerogenen und toxischen Wirkung von Diäthylnitrosamin auf die Rattenleber

Summary Rats treated by i.p. injections of a homologous thymus are protected, probably by greater reactivity, against the toxic and carcinogenic influence of diethylnitrosamine on the liver, effects that increase with time in untreated controls, long after cessation of drug administration, as is shown by the greater extent of degeneration in animals killed at longer than at shorter intervals.

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Die Arbeit wurde durch die Ludwig-Boltzmann-Gesellschaft zur Förderung der wissenschaftlichen Forschung in Österreich unterstützt.     

Freisetzung von Kalium aus denerviertem und innerviertem Skelettmuskel durch Acetylcholin

Summary Both hind limbs of cats (one being normally innervated, the other 8–12 days after denervation) were perfused and the quantities of potassium liberated from the two limbs in response to intraarterial injections of varying amounts of acetylcholine were compared by collecting the venous outflow from both sides separately; considerably larger quantities of potassium were found to be liberated from the denervated than from the innervated muscle after equal doses of ACH; the threshold dose of ACH for eliciting a measurable liberation of potassium being much lower on the denervated side. The dose response relation between injected ACH and potassium-liberation is of a different nature for innervated and denervated muscle. The results obtained are compatible with expectations derived from the short circuit theory of the transmitter action on the neuromuscular endplate (Fatt andKatz). The reasons of the difference in the dose relations for the innervated and denervated muscle are discussed.