琥乙红霉素颗粒剂溶出度方法的研究

摘要 根据国家药典委员会2010版药典品种对颗粒剂型增加溶出度检查的要求，对该品种的质量进行更有效的控制，建立琥乙红霉素颗粒的溶出度测定方法。对荷移比色法和硫酸显色法进行了比较，因硫酸显色法重现性和精密度好，灵敏度高，显色后溶液的稳定性强，显色剂易得等特点，仍沿用此方法。     

不同厂家盐酸二甲双胍片体外溶出度的比较

为比较6个厂家盐酸二甲双胍片体外溶出度,为临床用药提供参考.采用转篮法和紫外分光光度法对6个厂家生产的盐酸二甲双胍片的体外溶出度进行测定.结果6个厂家的盐酸二甲双胍片的体外溶出度均符合<中国药典>2005年版的规定,但各厂家盐酸二甲双胍片的体外溶出参数m、T30、 T50、 Td和T80间存在显著差异(P<0.01).说明不同厂家的产品溶出度的明显差异,应进一步对目前正在使用的这6种产品进行评价,以期对盐酸二甲双胍片的使用和采购提供一定参考.     

冬虫夏草体外溶出度研究

依据《药典》中的溶出度测定法进行冬虫夏草纳米粉胶囊、冬虫夏草粗粉胶囊及冬虫夏草药材的体外溶出实验.实验显示,冬虫夏草药材在10 min时溶出最多,冬虫夏草纳米粉胶囊及冬虫夏草粗粉胶囊都在40min时达到溶出最高点,而纳米粉溶出度高达100%.结果表明,装入胶囊的冬虫夏草粉比未装入胶囊的冬虫夏草药材,溶出度稳定,且冬虫夏草纳米粉溶出度最高.     

光纤传感过程监测格列齐特片(Ⅱ)溶出度

建立用光纤药物溶出度实时测定仪考察格列齐特片溶出过程的方法.结果 表明格列齐特在15.6~97.2 μg/mL的浓度范围内,吸收度和浓度的线性关系良好,与UV方法比较无显著性差异(P ＞ 0.05),该法用于检测格列齐特片溶出过程,显示药物实时溶出曲线图,获得的数据信息完整,反映了药物在体外溶出的全过程,且具有方便、快捷等优点.用光纤溶出度实时测定仪监测市售格列齐特片的溶出过程,该药品溶出度符合国家药典的要求.     

布洛芬颗粒的全面质量检测与分析

通过对该布洛芬颗粒进行全面质量检测确保此布洛芬颗粒符合《中国药典》规定.根据《中国药典》要求,采用紫外分光光度法、高效液相色谱法对布洛芬颗粒进行粒度、装量差异、干燥失重、溶出度检查,质量检测.结果表明:所选布洛芬颗粒的粒度、装量差异、干燥失重、溶出度检查,质量检测均符合标准.该布洛芬颗粒为合格产品,允许流通.     

阿奇霉素纳米晶体片剂的制备及其质量评价

以纳米晶体技术为基础制备阿奇霉素纳米晶体片剂,以期提高阿奇霉素的溶出度。采用介质研磨法制备阿奇霉素纳米晶体,在此基础上制备阿奇霉素纳米晶体片剂。参考《中华人民共和国药典》对其质量进行评价,采用浆法测定溶出度,HPLC法测定含量和有关物质。通过影响因素试验、加速试验及留样试验,考察片剂的稳定性。自制阿奇霉素纳米晶体片剂符合《中华人民共和国药典》2010版二部附录片剂项下要求,溶出度较上市片剂显著提高。影响因素试验结果表明,自制片剂对高温和强光较稳定,但对环境湿度较为敏感。加速试验及留样试验结果表明,自制片剂6个月内较为稳定,贮存时应置于密闭、干燥阴凉处。     

不同材质丸芯对VE缓释微丸溶胀性及VE溶出度影响的探讨

目的考察自制的不同丸芯对VE缓释微丸溶胀性及丸芯对VE溶出度的影响。方法将微丸放置在有水环境下观察其吸水溶胀程度和破碎程度,采用《中国药典》溶出度测定方法测定VE的溶出度。结果溶胀速度为蔗糖丸芯混合丸芯微晶纤维素丸芯,说明丸芯的溶解性能对微丸制成品的溶胀速度有一定的影响;结论溶出度试验结果表明三个样本的VE溶出度基本持平,说明不同丸芯对微丸制成品的溶出度影响不大。     

酒石酸氢可酮片溶出度测定的方法学验证

目的:对酒石酸氢可酮片的溶出度检查进行方法学验证.方法:参照《中国药典》(2010年版二部附录XC第二法)对其溶出度进行检查.采用高效液相法,计算每片的溶出量,进行方法学验证.结果:以酒石酸氢可酮对照品浓度(μg/mL)为横坐标、峰面积为纵坐标,绘制标准曲线,并对测得的数据进行回归分析,酒石酸氢可酮浓度在2.04~20.40μg/mL范围内与峰面积呈良好的线性关系.取酒石酸氢可酮片进行精密度试验、干扰性试验、稳定性试验、重复性试验、回收率试验、溶出度均一性试验(批内)、滤膜吸附的验证、检测限及定量限的测定均符合要求.结论:方法学研究结果表明,用本方法可以真实、有效、准确的测定酒石酸氢可酮片的溶出量,故本方法可行,可用于该产品的质量控制.     

环糊精诺氟沙星片剂的制备及溶出度考察

采用正交实验优化诺氟沙星片剂的制备条件,获得最佳处方:淀粉为填充剂,质量分数为5%的羧甲基淀粉钠(CMS-Na)为崩解剂,1%的滑石粉为润滑剂,10%的淀粉浆为黏合剂.为增大诺氟沙星药物的溶出,采用研磨法制备β-环糊精诺氟沙星包合物,经湿法制粒压片工艺制备环糊精诺氟沙星片剂.环糊精诺氟沙星片的片重差异、脆碎度和崩解时限均符合2010版中国药典要求,其中诺氟沙星的溶出度得到有效改善,解决了诺氟沙星片剂对照组的主药溶出度低的问题.采用优化处方和制备工艺,制备环糊精诺氟沙星片,可改善难溶性诺氟沙星药物的溶出度且工艺简单易行.     

大麻药总皂苷滴丸制备工艺及溶出度研究

为确立大麻药总皂苷滴丸的最佳成型工艺并考察其溶出度,以滴丸的成型率为评价指标,对大麻药滴丸基质与冷却剂的选择、大麻药与基质的配比、滴制的温度、滴距、滴速进行了单因素分析,并在此基础上以正交试验通过丸重差异、溶散时限和外观质量3个指标对上述主要影响因素进行了优选,采用转篮法和HPLC测定了其溶出度和含量.结果表明:大麻药总皂苷滴丸的最佳工艺条件为B3A1C1D2,即药物基质质量比为1∶4,PEG4000-PEG6000基质质量比为2∶1,滴制温度为70℃,滴距为5 cm,此条件下滴丸各项指标最好.说明该工艺简便可行,评价指标可靠合理,滴丸溶出度良好,符合2010年版中国药典对滴丸制剂的要求.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with     

Journal of Donghua University ( English Edition) Contents of Volume 31

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Brief Introduction to “Journal of Jilin University( Science Edition) ”

<正>"Journal of Jilin University(Science Edition)"is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the Peoples Republic of China.The journal started publication in 1955.The original name at starting publication was"Journal of Natural Science of Northeast People University",which was changed into"Acta Scientiarum Naturalium Universitatis Jilinensis"in 1958 owing to the name change of the university.The present journal name has