生物芯片技术:为生命解秘

生物芯片技术通过微加工工艺在厘米见方的芯片上集成有成千上万个与生命相关的信息分子，它可以对生命科学与医学中的各种生物化学反应过程进行集成，从而实现对基因、配体、抗原等生物活性物质进行高效快捷的测试和分析。它的出现将给生命科学、医学、化学、新药开发、生物武器战争、司法鉴定、食品与环境监督等众多领域带来巨大的革新     

微流控芯片技术的发展史及其应用的研究进展

微流控芯片技术是把生物和化学等领域所涉及的样品制备、生物与化学反应、分离与检测等基本操作单元集成到一块几平方厘米的芯片上,用以完成不同的生物或化学反应,并对其产物进行分析的一种技术,通俗言之,就是把实验室搬到芯片上.与传统的分析手段相比,具有分析快速、消耗低、微型化、自动化等优点.阐述了该技术的发展史及在医药、生命科学、公共卫生等领域的应用.     

神奇的生物芯片

你知道吗,在20世纪的科学史上有两大高新技术对人们的日常生活起了巨大的影响。其一是70年代的计算机芯片技术的出现,它把电子器件集成在一块又小又薄的集成板(芯片)上,从而导致了计算机技术的飞速发展以及信息产业的诞生,打造了像比尔·盖茨那样的亿万富翁;其二就是90年代出现的生物芯片技术,生物芯片可以像心脏瓣膜、关节等人造器官一样植入人体,从而开创了生命科学和医学革命的新时代。     

Z-L-Phe-OH-NBD分子印迹聚合物微分析通道的制备及其分子识别研究

微分析芯片又称微全分析系统,是将微制作技术与化学及生命科学相结合,实现从试样预处理、反应、分离到检测整个分析过程的集成化和微型化.由于它节省试剂和样品、分析速度快、灵敏度高而发展迅速,在生物、医学、食品卫生、新药合成与筛选、环境检测以及国防科学诸多领域受到极大关注.     

论生命深构造——新适应主义生物学的发展及其新理论综合

近几十年来,生命科学出现了一个重要的新方向--"种内适应性差异的比较研究". 它主要发端于生活史进化生态学、行为对策生态学、逆境与协迫生物学、表型可塑性研究和进化病理生理学.这一研究方向的性质是"微观生理学水平上的进化还原研究",简称为"新适应主义"或"生理达尔文主义". 它的发展正在成功地将达尔文范式引入到广大的微观生理科学的领地中,它对生物的表型和微观生理过程的重视及其新理论的发展正在为当代生命科学许多疑难领域的实验研究提供了全新的分析工具,并将会对神经科学、医学生理学、发育生物学等领域的研究产生深远的影响.     

医药院校中加强培养实验动物福利理念的重要性

在生命科学飞速发展的今天,实验动物科学作为生命科学研究的基础和支撑条件,影响着生命科学许多研究领域,成为现代科学的重要组成部分,已受到世界各国政府和科技界的重视,甚至成为衡量一个国家生命科学研究水平高低的重要指标之一;同时它又是生物学、医学、药学等发展的推进剂,其提高和发展又会把生命科学领域的诸多课题研究引入新的境地。     

实验用小型猪在比较医学中的研究应用与发展

生命科学由于与人类关系的密切性以及对人类发展的重要性,吸引越来越多的科技工作者投入到该领域的研究,促使学科理论和技术不断出现新的突破,人类基因组计划的成功完成,更是为本学科的进一步发展提供了基础。医学科学作为生命科学的重要组成部分,生命科学的进步必然推动医学科     

天然活性物超临界CO2萃取中破壁和集成技术

超临界CO2萃取技术反应条件温和,无毒,被誉为绿色加工技术.萃取中的破壁技术及集成技术对天然活性物的超临界CO2萃取效率和生产成本有一定影响.破壁技术包括超声破壁、微波破壁、酶法破壁、压差破壁、浸泡破壁和研磨破壁等;集成技术包括与真空冷冻干燥技术集成,与分子蒸馏技术集成,与喷雾干燥技术集成,与挤压膨化技术集成等.     

工作流技术与Web服务

工作流技术是一种实现业务过程的分析、建模、优化、管理与集成,以及最终实现业务过程自动化的核心技术.它可以与其它应用系统有效结合,构建各种业务管理系统.Web服务作为一种基于标准的应用集成方式,具有松散耦合、动态性、高度可集成能力等优势,可以使应用程序在网络上进行无缝集成.而基于Web服务的工作流管理系统与其他工作流系统相比,在跨平台和系统边界能力方面独具优势.     

面向网络的空间数据多级集成和服务模式

在对现有空间信息集成技术和方法研究的基础上,综合应用需求、数据服务方式和Web服务技术,提出并建立一种面向网络的空间数据多级集成和服务模式.该模式可由使用者根据需要选择相应的集成模式,满足各自的需求.它将面向网络的空间数据集成用数据级、平台级、Web服务级和应用级等4个模式层次来进行描述,使各种数据集成问题归于各个层次的相应模式的数据集成和存取问题.最后,运用Web地图服务,实现一个面向服务的空间数据集成和服务系统,并验证多级集成和服务模式框架理论和技术.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with     

Journal of Donghua University ( English Edition) Contents of Volume 31

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