共查询到1条相似文献,搜索用时 0 毫秒
1.
Lowe DB Shearer MH Jumper CA Kennedy RC 《Cellular and molecular life sciences : CMLS》2007,64(7-8):803-814
SV40 was discovered as a contaminate of poliovirus vaccine lots distributed to millions of individuals in the United States
between 1955 and 1963 while contaminated vaccine batches were later circulated worldwide. After SV40 was observed to cause
in vitro animal and human cell transformations and in vivo tumor formations in animals, the search for a connection between the virus and human malignancies has continued to the present
day. Different molecular methods have been used to detect SV40 gene products in a variety of human cancers, though SV40 causality
in these tumor types has yet to be established. These data, however, are not without controversial issues related to inconclusive
SV40 serological and epidemiological evidence alongside tools and methodologies that may contribute to false-positive results
in human specimens. This review will also explore how vaccination against SV40 protein products may be used to help prevent
and treat individuals with SV40-expressing cancers.
Received 19 September 2006; received after revision 8 November 2006; accepted 13 December 2006 相似文献