Proteins and atherosclerosis

Résumé Les examens macroscopiques et microscopiques effectués sur l'aorte des lapins ont été mis en corrélation avec le degré de concentration de la protéine plasmique. Les résultats indiquent qu'une augmentation des protéines plasmiques correspond a un degré plus élevé d'athérosclérose.     

Lens regeneration from the dorsal iris inEurycea bislineata,the two-lined salamander

Summary Following lens removal from the eye of adultEurycea bislineata, the northern (USA) 2-lined salamander, it was found that this salamander has the capacity for lens regeneration. Its widespread distribution and high percentage of regenerative success suggests it as a suitable organism for the study of this differentiative phenomenon.This research was supported by N.I.H. grant EY-02534 from the National Eye Institute. We thank S.M. DiRienzo for excellent technical assistance.     

Histochemical detection of the position of metal microelectrode

Zusammenfassung Die Methode der histochemischen Detektion der Lage der Metallmikroelektrode wird beschrieben. Nachdem die Aktionpotentiale registriert worden sind, wird das Eisen aus der Mikroelektrode durch Elektrolyse ins Gewebe eingeführt, und anschliessend in Serienschnitten mit histochemischen Methoden nachgewiesen.     

Proteins of venezuelan equine encephalomyelitis virions

. : (. . 59,000–61,000 ), (34,000–38,000) (15,000–18,000).     

Biological Roles of Neural J Proteins

J proteins are chief regulators of the Hsp70 family, a highly conserved family of ATPases that mediate conformational changes in a broad range of proteins. The J protein family has been the central focus of numerous prokaryote and eukaryote biologists. Common questions that arise include: How does the J protein/Hsp70 machinery support protein folding? What role do J proteins play in protein misfolding and neurodegenerative disorders? Can the J protein/ Hsp70 machinery be harnessed to provide a rational basis for recombinant protein production? The current progress that has resulted from the convergence of biochemistry with Escherichia coli and Saccharomyces cerevisiae genetics has accelerated the pace at which these questions are being elucidated. We are beginning to gain some insights into the neuronal network of J proteins. Here, we highlight recent advances in our understanding of how select J proteins harness Hsp70 s for fundamentally important conformational work in neurons.     

Identification of uncommon amino acids in the lentil seed (Lens culinaris Med.).

The fraction of the free basic amino acids in the lentil seed was shown to contain gamma-hydroxyarginine, gamma-hydroxyornithine and homoarginine besides the common amino acids. Similar distribution was found in 5 varieties of lentil, with hydroxyarginine and arginine dominating. The significance of these findings with regard to chemotaxonomy and lentil consumption is discussed.     

Identification of uncommon amino acids in the lentil seed (Lens culinaris Med.)

Summary The fraction of the free basic amino acids in the lentil seed was shown to contain -hydroxyarginine, -hydroxyornithine and homoarginine besides the common amino acids. Similar distribution was found in 5 varieties of lentil, with hydroxyarginine and arginine dominating. The significance of these findings with regard to chemotaxonomy and lentil consumption is discussed.     

The effect of the change of position on the nonesterified fatty acids

Resumen El cambio postural ocasiona un aumento significativo de los ácidos grasos libres plasmáticos. El test bioquímico postural propuesto es útil para distinguir hipotensión ortostática asimpáticotónica de la de órgano efector.     

On the relative position of the centromere of chromosome 3 inDrosophila melanogaster

Zusammenfassung HomozygoteDrosophila-melanogaster-Weibchen, genetisch markiert mit scarlet (st), Kinked (Ki) und pink peach (P^p) wurden bestrahlt, um Compound-3-Chromosomen herzustellen. Es wurden ausschliesslich st/st- und P^p Ki/Ki(?) P^p-Compoundchromosomen gefunden. Dies zeigt, dass das Zentromer links der Markierung Kinked liegt.

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This work was supported by Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung.     

Binding of Lens culinaris lectin to sea urchin embryo chromatin.

Lentin binds specifically to sea urchin embryo chromatin. This binding is saturable and inhibited by alpha-methyl-mannose. Scatchard plot analysis of the binding reaction suggests a single binding site.     

Welcome the Family of FANCJ-like Helicases to the Block of Genome Stability Maintenance Proteins

The FANCJ family of DNA helicases is emerging as an important group of proteins for the prevention of human disease, cancer, and chromosomal instability. FANCJ was identified by its association with breast cancer, and is implicated in Fanconi Anemia. Proteins with sequence similarity to FANCJ are important for maintenance of genomic stability. Mutations in genes encoding proteins related to FANCJ, designated ChlR1 in human and Chl1p in yeast, result in sister chromatid cohesion defects. Nematodes mutated in dog-1 show germline as well as somatic deletions in genes containing guanine-rich DNA. Rtel knockout mice are embryonic lethal, and embryonic stem cells show telomere loss and chromosomal instability. FANCJ also shares sequence similarity with human XPD and yeast RAD3 helicases required for nucleotide excision repair. The recently solved structure of XPD has provided new insight to the helicase core and accessory domains of sequence related Superfamily 2 helicases. The functions and roles of members of the FANCJ-like helicase family will be discussed. Received 17 September 2008; received after revision 24 October 2008; accepted 28 October 2008     

嗜热蛋白稳定机理研究进展

嗜热蛋白是一类主要来源于嗜热微生物的热稳定蛋白，能够在高温下长时间保持活性而不变性．通过对嗜热蛋白耐热机理的深入研究，对于人们深入理解蛋白质的折叠、结构与功能、进化以及在蛋白质加工中对蛋白质分子的定向设计和改造有着重要的意义。本文主要介绍了目前对嗜热蛋白的研究概况和主要进展。     

嗜热蛋白热稳定机理研究进展

嗜热蛋白是一类主要来源于嗜热微生物的热稳定蛋白,能够在高温下长时间保持活性而不变性,通过对嗜热蛋白耐热机理的深入研究,对于人们深入理解蛋白质的折叠、结构与功能、进化以及在蛋白质加工中对蛋白质分子的定向设计和改造有着重要的意义.本文主要介绍了目前对嗜热蛋白的研究概况和主要进展.