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Summary Glucagon infusion caused a marked increase of brown fat venous FFA concentration, but the extent of increase was less in cold-acclimatized rats than in warm-acclimatized ones. Systemic venous FFA was not appreciably influenced by glucagon. Propanolol did not modify the changes induced by glucagon.The authors wish to thank the Novo Industri A/S for the gift of glucagon. — Address of Tomie Ohno: College of School Health, Hokkaido University of Education, Asahikawa 070 (Japan). 相似文献
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Pujol E Rodríguez-Cuenca S Frontera M Justo R Lladó I Kraemer FB Gianotti M Roca P 《Cellular and molecular life sciences : CMLS》2003,60(9):1982-1989
Gender- and site-related differences in the lipolytic capacity, at the different steps of the adrenergic pathway, in gonadal and inguinal white adipose tissue (WAT), were assessed by studying 2A-adrenergic receptor (AR), 3-AR and hormone-sensitive lipase (HSL) protein levels, and by determining the lipolytic response to different agents. Gonadal WAT showed a lower 2A/3-AR ratio, a greater lipolytic capacity in response to AR agonists, and higher HSL activity and protein levels than inguinal WAT. In female rats, we found greater 2A-AR protein levels and 2A/3-AR ratio compared to their male counterparts, but, on the other hand, a higher lipolytic response to -AR agonists and a greater lipolytic capacity at the postreceptor level, including a more activated HSL protein. Thus, the lipolytic capacity was clearly higher in gonadal than in inguinal WAT, at the different steps of the adrenergic pathway studied. Moreover, in both tissues, females showed a greater inhibition of lipolysis via 2-AR, which was counteracted by the higher lipolytic capacity at the postreceptor level.Received 1 April 2003; received after revision 11 June 2003; accepted 23 June 2003 相似文献
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V. Felt B. Schovanec P. Beneš F. Plzák V. Vrbenský 《Cellular and molecular life sciences : CMLS》1962,18(8):379-379
Zusammenfassung Die Freisetzung freier Fettsäuren aus dem mesenterialen Fettgewebe von Ratten ist bei hyperthyroiden Tieren grösser, bei hypothyreoiden geringer und wird besonders bei hyperthyreoiden Ratten durch Adrenalin positiv gesteigert. Glukose beeinflusst die durch Adrenalin gesteigerte Abgabe der freien Fettsäuren aus dem Fettgewebe von euthyreoiden Tieren nicht, setzt diese jedoch bei hyperthyreoiden Ratten herab. 相似文献
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M Berlan 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(17):1677-1680
Phentolamine, an alpha blocking agent, potentializes the adrenergical lipolytic effect of isolated fat cells of Canine omental adipose tissue when their average diameter is greater than 80 micrometers. This effect can be found also in isolated fat cells of mesenteric adipose tissue, spontaneously less sensitive with catecholamines. Phenylephrine, alpha sympathomimetic, partially inhibits the lipolytic effect stimulated by isoprenaline. 相似文献
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The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evlauation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO hold trans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydrxonaphthalene) incorporates trans-transcoid conformation and primarily acts on post-synpatic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors. 相似文献
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I. C. Lopez-Mejia J. Castillo-Armengol S. Lagarrigue L. Fajas 《Cellular and molecular life sciences : CMLS》2018,75(6):975-987
In the course of the last decades, metabolism research has demonstrated that adipose tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy homeostasis. Numerous novel regulators of adipose tissue differentiation and function have been identified. With the constant increase of obesity and associated disorders, the interest in adipose tissue function alterations in the XXIst century has become of paramount importance. Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies. 相似文献
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Phosvel, an organophosphorus pesticide, was stored in the adipose tissue of hens after they were given daily a single oral dose. The concentration of Phosvel in fat was related to the size of the daily dose. 相似文献
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M M Couillin A Boué N Van-Cong D Weil R Rebourcet J Frézal 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1975,281(4):293-295
The study of permissivity for poliovirus and the study of enzymatic markers in man-mouse somatic cell hybrids presents a very positive correlation between the presence of the poliovirus receptor and the presence of a well known enzyme marker, the phosphoglucoseisomerase (GPI), localized on the human chromosome F 19. 相似文献
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Cold acclimatization induces morphological and compositional modifications of rat epididymal adipose tissue: a decrease in fat cell size, an increase of fat cell number per g of tissue, but no significant increase in total fat cell number in the tissue; finally, an increase in protein content and a decrease in triglyceride content. 相似文献
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Résumé Les membranes plasmatiques des tissus adipeux brun et blanc sont isolées de la fraction microsomale selon une modification de la technique décrite parKamat etWallach
8. Les résultats de l'analyse enzymatique démontrent un degré de purification satisfaisant des membranes plasmatiques et des microsomes.
This work was supported by a grant from the Fonds national suisse de la Recherche scientifique. 相似文献
This work was supported by a grant from the Fonds national suisse de la Recherche scientifique. 相似文献
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J Bensimon 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(19):1959-1962
In a first experiment, cells were cultured in media supplemented by nickel sulphate, irradiated in same media and cultured in same media after irradiation. In a second experiment, cells were cultured during 18 hrs. in media supplemented by nickel sulphate, and then cells were washed and cultured in normal media where they were irradiated. The nickel sulphate toxicity appears as a creasing function of the nickel sulphate concentration and the nickel sulphate action endurance. The nickel sulphate toxic effect is amplified by X-Rays. This amplification is a time function that depends on the X-Ray dose, nickel sulphate concentration and period of time from the outset of culture to the irradiation. The nickel sulphate toxic effect appears faster when nickel works after X-Rays. 相似文献
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S Dunel P Laurent 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(20):2011-2014
The current findings from gill vascular cast preparations in the eel emphasize the division in each primary lamella of the afferent vasculature into two efferent pathways: an arterial pathway (via the secondary lamellae and the efferent branchial artery to the dorsal aorta), a venous pathway (via the central lamellar compartment and the branchial vein to the sinus venosus). By the same technique two antagonist mechanisms have been shown presumably controlling the blood flow in both pathways. 1. Acetylcholine increases the filling of the central lamellar compartment by constricting the efferent arterial sphincters and therefore increases the venous return. 2. Epinephrine impairs the filling of the central lamellar compartment (by acting on alpha receptors) and dilates the arterial pathway (by acting on beta receptors). Therefore the stimulation of these two synergic receptors by epinephrine increases the systemic blood flow. 相似文献
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