免疫因子与间质性膀胱炎/膀胱疼痛 综合征相关性研究

目的探讨免疫因子在间质性膀胱炎/膀胱疼痛综合征发生与进展中的作用.方法选取间质性膀胱炎/膀胱疼痛综合征患者42例为观察组,同期行输尿管镜检查的18例患者正常膀胱组织为对照组.透射电子显微镜观察浆细胞和肥大细胞的表达;免疫组化法检测白细胞介素(IL)-2,IL-10,Siglec-15的表达水平;进行盆腔疼痛和尿频、尿急症状(PUF)评分,分析免疫因子表达与PUF评分的关系.结果观察组42例间质性膀胱炎/膀胱疼痛综合征患者中36例在透射电子显微镜下观察可见浆细胞和肥大细胞,其中肥大细胞出现脱颗粒状态26例;对照组膀胱黏膜组织中透射电子显微镜下未见浆细胞和肥大细胞.观察组患者膀胱黏膜组织中IL-2,IL-10呈弱阳性、强阳性表达的比例明显高于对照组,IL-2,IL-10呈阴性表达的比例明显低于对照组,差异具有统计学意义(P0.01);膀胱黏膜组织中Siglec-15表达情况在两组间差异无统计学意义(P0.05).观察组IL-2,IL-10强阳性患者的PUF评分明显高于弱阳性和阴性患者,差异具有统计学意义(P0.01); Siglec-15阴性患者的PUF评分明显低于阳性和强阳性患者,差异具有统计学意义(P0.01).结论间质性膀胱炎/膀胱疼痛综合征患者膀胱黏膜组织中存在浆细胞浸润、肥大细胞出现脱颗粒; IL-2,IL-10表达水平与症状程度呈正相关,Siglec-15表达水平与症状程度呈负相关.     

分析降钙素原和血小板计数对血流感染的早期预测价值

探讨降钙素原（PCT），血小板计数(PLT)，白细胞计数(WBC)对早期血流感染是否存在预测价值。通过回顾性病历分析2017年7月—2019年7月甘肃省人民医院ICU169例行血培养患者的资料，比较血培养阳性组和阴性组，以及血培养阳性亚组间血清PCT、PLT计数，WBC计数水平的差异，采用受试者工作特征（ROC）曲线评价和比较上述指标的预测价值。PCT水平血培养阳性组明显高于阴性组，革兰氏阴性组（G-组）明显高于革兰氏阳性组（G+组），差异存在统计学意义（P<0.05）,PLT水平血培养阳性组明显低于阴性组，差异存在统计学意义（P<0.05），但G+组和G-组间无统计学意义，WBC在血培养阳性组和阴性组水平均升高，但两组间差异无统计学意义。PCT、PLT和WBC预测血培养阳性的受试者工作特征（ROC）曲线下面积分别为0.779(P<0.05)、0.60(P<0.05)和0.24(P<0.05)。其中PCT预测血培养阳性临界值为0.065 ng/L，敏感度为74.3%，特异度为86.3%;PLT预测的临界值为108.5×109/L，敏感度为72.6%，特异度...     

STK15、P53在口腔黏膜癌变过程中的表达及意义

目的:通过了解丝氨酸/苏氨酸激酶15(STK15)及蛋白质53(p53)在口腔黏膜癌变过程中的表达变化,探讨p53/STK15转激活非依赖通路在OSCC发生发展中的作用及意义.材料与方法:正常口腔黏膜8例,上皮异常增生组织27例,口腔鳞状细胞癌43例石蜡包埋组织,采用免疫组化SABC法了解STK15及p53蛋白表达情况,分析其在各组间的差异及其临床病理学意义.结果:STK15在正常口腔黏膜阴性表达,在上皮异常增生组及OSCC中阳性表达率分别为40.74%(11/27)、67.44%(29/43),其阳性表达率在各组间的差异均有统计学意义(P＜0.05).p53在正常口黏膜阴性表达,在上皮异常增生组及OSCC中阳性表达率分别为37.04%(10/27)、48.84%(21/43),与正常组相比差异均有统计学意义(P＜0.05),OSCC与异常增生组相比差异无统计学意义(P＞0.05).在正常口腔黏膜、上皮异常增生及OSCC中STK15和p53同时阳性表达率分别为0%(0/8)、18.52%(5/27)、41.86%(18/43),各组间差异均有统计学意义(P＜0.05).OSCC中STK15)阳性表达率在p53阳性表达组和p53阴性表达组分别为85.71%(18/21)、50%(11/22),两组间比较差异有统计学意义(P＜0.05).STK15、p53阳性表达率在OSCC伴有淋巴结转移组高于不伴淋巴结转移组,且差异有统计学意义(P＜0.05).结论:①STK15过表达是口腔黏膜癌变过程的早期事件并且可能与口腔癌发生进程有关.②同时发生突变型p53和STK15表达增高可能在OSCC发生中有意义,从异常增生最终演变成鳞癌可能有二者协同作用的参与.③STK15过表达对OSCC淋巴结转移有影响,可能成为判断OSCC预后的重要指标之一.     

HPV分型检测在宫颈癌及癌前病变筛查中的临床应用价值

观察分析高台县人民医院HPV分型检测用于宫颈癌及癌前病变筛查的应用价值。选择2015年1月至2017年12月经高台县人民医院收检的液基细胞学检查3128例,共检出的302例非典型鳞状细胞增生患者,进行HPV分型检测及阴道镜多点取材活检诊断,评价两者之间的相关性。HPV阳性患者共215例,感染率71.19%(215/302),HPV阳性患者及阴性患者年龄、生育史、体重等一般资料组间差异无统计学意义(p0.05),但阳性组病理活检确诊宫颈癌及癌前病变的比例为22.33%(48/215),阴性组为6.90%(6/87),组间差异具有统计学意义(p0.05)。HPV分型检测用于宫颈癌及癌前病变的筛查具有较高的应用价值,值得临床推广应用。     

CEACAM6在卵巢粘液性肿瘤中的表达及其诊断意义

目的 探讨CEACAM6在卵巢粘液性肿瘤中的表达及其诊断意义.方法 利用免疫组化法检测CEACAM6在不同卵巢粘液性肿瘤、浆液性肿瘤和正常卵巢组织中表达情况.结果 21例良性粘液性囊腺瘤均为阴性或弱阳性表达,19例交界性肿瘤中16例阳性表达(84.2%);21例高分化癌中17例阳性表达(80.9%).11例低分化癌中7例2～3分阳性表达(63.6%);粘液性肿瘤中,良性粘液性囊腺瘤和交界性肿瘤、高分化癌、低分化癌相比均有统计学差异(P=0.000);交界性粘液性肿瘤、高分化癌、低分化癌之间两两比较,差异均无统计学意义(P＞0.05).浆液性肿瘤中,良性、交界性和恶性肿瘤CEACAM6表达均为阴性或弱阳性;15例正常卵巢组织阴性表达.粘液性肿瘤和浆液性肿瘤以及正常卵巢组织中CEACAM6的表达具有统计学差异(P=0.000).结论 CEACAM6特异性地表达于粘液性肿瘤中,而且CEACAM6的异常表达在卵巢粘液性肿瘤恶性变过程中是一个早期事件,起始于交界性肿瘤.     

大剂量氨溴索治疗老年重症肺炎的临床探讨

观察大剂量氨溴索用于老年重症肺炎患者的实际疗效,探讨该用药方案的临床应用价值。选择2016年4月至同年6月我院收治的108例老年重症肺炎患者,按照随机原则分为观察组(n=54)及对照组(n=54),其中观察组剂量为600mg,每日单次静脉泵入给药;对照组剂量为80~100mg,每日单次静脉推注给药。观察指标包括两组患者影像学结果及不良反应发生率。观察组中共52例患者累及肺叶阴影完全消失,有效率达到96.30%(52/54),对照组中共44例患者累及肺叶阴影完全消失,有效率为81.48%(44/54),有效率组间差异具有统计学意义(p0.05);肝肾功能异常等不良反应发生率组间差异无统计学意义(p0.05)。大剂量氨溴索用于老年重症肺炎的临床治疗,显著提升了治疗效果,且并未增加不良反应的风险,是一种值得临床推广应用的用药方案。     

S-1联合奥沙利铂方案一线治疗晚期胃癌 有效性及安全性分析

目的探讨S-1联合奥沙利铂方案一线治疗晚期胃癌的有效性及安全性.方法选取60例晚期胃癌患者作为研究对象,随机将其分为研究组和对照组,研究组采用S-1+L-OHP方案进行治疗,对照组采用FOL-FOX方案进行治疗.结果研究组和对照组患者有效率比较差异无统计学意义(P0.05);研究组疾病控制率为80.0%,优于对照组的53.3%,且差异具有统计学意义(P0.05);研究组和对照组中位TTP比较差异具有统计学意义(P0.05);两组中位OS比较差异无统计学意义(P0.05);研究组外周神经毒性发生率明显高于对照组,差异具有统计学意义(P0.05),其余不良反应发生率比较差异均无统计学意义(P0.05).结论 S-1联合奥沙利铂治疗晚期胃癌具有良好的疗效及安全性,与FOL-FOX方案比较,不良反应低,且静脉滴注时间短,患者依从性好.     

奥氮平联合利培酮治疗精神分裂症的疗效探究

探究奥氮平联合利培酮治疗精神分裂症的疗效。研究对象为2018年10月～2019年10月期间天水市第三人民医院精神科收治的精神分裂症患者86例,以随机数字法为分组依据,将其分成2组,对照组43例服用利培酮,研究组43例在对照组基础上增服奥氮平。对比两组患者临床疗效、阳性和阴性症状量表(PANSS)评分、不良反应发生率情况。①研究组总有效率97.67%,对照组总有效率93.02%,两组比较差异无统计学意义(P>0.05);②治疗后两组阳性症状评分、阴性症状评分、一般精神病性评分、总分均小于治疗前(P<0.05),且治疗后研究组阳性症状评分、阴性症状评分、一般精神病性评分、总分均小于对照组(P<0.05);③研究组不良反应发生率11.63%低于对照组30.23%(χ2=4.497,P=0.034)。联合奥氮平与利培酮,用其治疗精神分裂症,疗效确切,阳性症状、阴性症状、一般精神病性改善更显著,安全性好。     

肝硬化腹水并发自发性腹膜炎42例临床分析

目的分析肝硬化并发自发性腹膜炎的临床特点及预后.方法对42例肝硬化并发SBP患者的临床资料进行回顾性分析.结果42例患者中,发热34例(80.9%),腹胀37例(88.4%),腹痛18例(42.1%),腹水PMN≥0.50 36例(85.5%).结论肝硬化并发SBP临床表现不典型,治愈、好转率低,腹水常规检查可早期诊断,腹水PMN比值是诊断SBP的可靠参数.     

奥曲肽和垂体后叶素联合硝酸甘油治疗食管胃底曲张静脉破裂出血疗效及副作用对比分析

目的采用随机分类方法,观察奥曲肽和垂体后叶素联合硝酸甘油两种方法治疗肝硬化食管胃底曲张静脉(EGV)破裂出血疗效及副作用.方法37例病例分成两组,奥曲肽组19例,垂体后叶素联合硝酸甘油组(以下简称联合用药组)18例.结果两组治疗食管胃底曲张静脉破裂出血止血成功率奥曲肽组85.5%,联合用药组85.0%.失败率奥曲肽组14.5%,联合用药组15.0%.两组差异无统计学意义(P＞0.05).副作用奥曲肽组10.5%,联合用药组27.7%(P＜0.05),差异有统计学意义.结论两组方法治疗EGV破裂出血止血成功率基本相似,但联合用药组副作用率明显高于奥曲肽组.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with