The finding of viral particles in spontaneous mammary adenocarcinoma in rats

Riassunto Per la prima volta viene segnalato il reperto di particelle virali in adenocarcinoma mammario spontaneo del ratto.     

Effect of growth hormone and prolactin on mouse transplantable mammary adenocarcinoma

Zusammenfassung Verabreichung von bovinem Wachstumshormon oder Schafsprolactin fördert das Wachstum von Adenokarzinom der Brust (MMC₁A) transplantiert in eine weibliche Maus R III oder von Adenokarzinom der Brust Eo 771 transplantiert in eine weibliche Maus C₅₇Bl.     

Evidence for mimicry by viral antigens in animal models of autoimmune disease including myocarditis

Molecular mimicry of viral antigens with self determinants has been proposed as one of the pathogenic mechanisms in autoimmune disease. Evidence of viral mimicry in animal models of autoimmunity is accumulating. Murine adenovirus, Semliki forest virus, lactate dehydrogenase-elevating virus, herpes simplex virus type-1, hepatitis B virus, encephalomyocarditis virus, Theiler's murine encephalomyelitis virus, Coxsackievirus and cytomegalovirus have been found to mimic physiologically important host proteins. However, epitope homology of a viral and self determinant is not in itself strong evidence for mimicry as a pathogenic mechanism. The mimicking determinant must also be capable of inducing disease in the absence of replicative virus. Animal models provide evaluation of the viral trigger, and development and therapy for autoimmune diseases. Identification of host proteins that can induce disease together with the knowledge of immune system dysregulation, genetic association and environmental factors may lead to improved immunotherapeutic strategies for human autoimmune diseases.     

Sandwich enzyme immunoassay of mouse mammary tumor virus

Summary A highly sensitive sandwich enzyme immunoassay for the mouse mammary tumor virus (MMTV) is described. The assay can detect 3 ng/ml of MMTV. The enzyme used is ß-D-galactosidase fromEscherichia coli and the solid phase used is a piece of silicon rubber.     

Indefinite in vivo life span of serially isografted mouse mammary gland

Zusammenfassung Durch wiederholte Transplantation liess sich Mammagewebe von Mäusen während einer Zeitspanne am Leben erhalten, welche die Lebensdauer von Mäusen wesentlich übertrifft.

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This work was supported by grants from the Jane Coffin Childs Memorial Fund for Medical Research, the Medical Research Council of Canada, and also partly by the National Cancer Institute of Canada. The author is indebted to Mrs.Sharon Griffin for her technical assistance.