Development of photosystem I and onset of generative phase in buckwheat

Summary The length of the generative phase and the development of photosystem I in buckwheat cotyledones were found to be correlated. Increasing days of light exposure help both of these processes. It is presumed that electron transfer during energy absorption probably serves as a prelude to further molecular events leading to the onset of the generative phase.A.N.P. is thankful to USSR Academy of Sciences and U.G.C. India for financial assistance for his visit under Cultural Exchange Programme and to Miss T.I. Vyacheslavova for helping as an interpreter during the visit. Suggestions from Acad. M.Kh. Chailakhyan during this work are duly acknowledged.     

The realizers and vehicles of mental representation

The neural vehicles of mental representation play an explanatory role in cognitive psychology that their realizers do not. Cognitive psychology individuates neural structures as representational vehicles in terms of the specific causal properties to which cognitive mechanisms are sensitive. Explanations that appeal to properties of vehicles can capture generalisations which are not available at the level of their neural realizers. In this paper, I argue that the individuation of realizers as vehicles restricts the sorts of explanations in which they can participate. I illustrate this with reference to Rupert’s (2011) claim that representational vehicles can play an explanatory role in psychology in virtue of their quantity or proportion. I propose that such quantity-based explanatory claims can apply only to realizers and not to vehicles, in virtue of the particular causal role that vehicles play in psychological explanations.     

Insulin acts on the hypothalamic glucose-facilitated neurons to induce hyperglycemia and hyperinsulinemia in the rat

Microinjection of insulin (0.04-0.12 IU/microliter) into the anterior hypothalamus or the lateral hypothalamus, but not the ventromedial hypothalamus of the rat brain, caused a dose-dependent rise in blood glucose and in serum insulin. The majority (71.5%) of the glucose-facilitated neurons recorded in the lateral hypothalamic area were excited by intracerebral injection of insulin. The data indicate that insulin acts on the hypothalamic glucose-facilitated neurons to induce hyperglycemia and hyperinsulinemia. It is unknown whether insulin normally reaches the hypothalamic area, or how it might do so.     

Insulin acts on the hypothalamic glucose-facilitated neurons to induce hyperglycemia and hyperinsulinemia in the rat

Microinjection of insulin (0.04–0.12 IU/l) into the anterior hypothalamus or the lateral hypothalamus, but not the vertromedial hypothalamus of the rat brain, caused a dose-dependent rise in blood glucose and in serum insulin. The majority (71.5%) of the glucose-facilitated neurons recorded in the lateral hypothalamic area were excited by intracerebral injection of insulin. The data indicate that insulni acts on the hypothalamic glucose-facilitated neurons to induce hyperglycemia and hyperinsulinemia. It is unknown whether insulin normally reaches the hypothalamic area, or how it might do so.This work was supported by grants from the National Science Council (Taipei, Taiwan, Republic of China).     

The effects of caffeine on physiological functions and mental performance

Summary Polygraphic monitoring of several physiological variables was done throughout an experiment investigating the effects of caffeine on mental performance. The experiment started with a mental maze learning task. Then the subjects were given the test beverages according to the group design (CC group (N=16)300 mg caffeine in decaffeinated coffee, DC group (N=16): decaffeinated coffee, WW group (N=8): warm water, and NB group (N=8): no beverage). The experiment continued with a letter cancellation task which was followed by a second mental maze learning task. The caffeine treated subjects differed from the other groups by increased regularity of letter cancellation performance, as indicated by decreases in intraindividual variance. They also differed from the other groups by a slight but significant acrodermal vasoconstriction. No intergroup differences were obtained for mental maze learning, heart rate, respiration, muscle tension, and skin conductance. The results suggest therefore that the drug at this dose level improves behavioral routine and speed rather than cognitive functions and that the vegetative side effects are minimal.     

The plasma level of some amino acids and physical and mental fatigue

Tryptophan is converted to 5-hydroxytryptamine (5-HT) in the brain and evidence is presented that an increase in the concentration of 5-HT can result in physical and mental fatigue during prolonged exercise. The entry of tryptophan in the brain is influenced by the plasma level of free tryptophan (that not bound to albumin) and, from competition for entry into brain, by the plasma level of branched chain amino acids. Hence, oral administration of branched chain amino acids could, theoretically, prevent the increase in 5-HT level during exercise and therefore delay physical and mental fatigue. Evidence in support of this hypothesis is presented.     

Geopsychology and geopsychopathology: mental processes and disorders associated with geochemical and geophysical factors

Temporal and regional variations in psychological processes have been associated with three geological factors. They are geochemical profiles, geomagnetic variations, and tectonic stresses. In the geochemical domain, copper, aluminum, zinc, and lithium may influence the incidence of thought disorders such as schizophrenia and senile dementia. These common elements are found in many soils and ground water. Geomagnetic variations have been correlated with enhanced anxiety, sleep disturbances, altered moods, and greater incidences of psychiatric admissions. The effects are usually brief but pervasive. Transient and very local epidemics of bizarre and unusual behaviors are sociological phenomena that sometimes precede increases in earthquake activity within a region; they have been hypothesized to be associated with tectonic strain. Many of the contemporary correlations between geological factors and human behavior are also apparent within historical data. The effects of geophysical and geochemical factors upon human behavior are not artifactual, but they are complex and often not detected by the limited scope of most studies.     

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development

Five types of zymogens of pepsins, gastric digestive proteinases, are known: pepsinogens A, B, and F, progastricsin, and prochymosin. The amino acid and/or nucleotide sequences of more than 50 pepsinogens other than pepsinogen B have been determined to date. Phylogenetic analyses based on these sequences indicate that progastricsin diverged first followed by prochymosin, and that pepsinogens A and F are most closely related. Tertiary structures, clarified by X-ray crystallography, are commonly bilobal with a large active-site cleft between the lobes. Two aspartates in the center of the cleft, Asp32 and Asp215, function as catalytic residues, and thus pepsinogens are classified as aspartic proteinases. Conversion of pepsinogens to pepsins proceeds autocatalytically at acidic pH by two different pathways, a one-step pathway to release the intact activation segment directly, and a stepwise pathway through a pseudopepsin(s). The active-site cleft is large enough to accommodate at least seven residues of a substrate, thus forming S₄ through S₃′ subsites. Hydrophobic and aromatic amino acids are preferred at the P₁ and P₁′ positions. Interactions at additional subsites are important in some cases, for example with cleavage of κ-casein by chymosin. Two potent naturally occurring inhibitors are known: pepstatin, a pentapeptide from Streptomyces, and a unique proteinous inhibitor from Ascaris. Pepsinogen genes comprise nine exons and may be multiple, especially for pepsinogen A. The latter and progastricsin predominate in adult animals, while pepsinogen F and prochymosin are the main forms in the fetus/infant. The switching of gene expression from fetal/infant to adult-type pepsinogens during postnatal development is noteworthy, being regulated by several factors, including steroid hormones. Received 25 May 2001; received after revision 27 August 2001; accepted 30 August 2001     

Understanding,explanation, and unification

In this article I argue that there are two different types of understanding: the understanding we get from explanations, and the understanding we get from unification. This claim is defended by first showing that explanation and unification are not as closely related as has sometimes been thought. A critical appraisal of recent proposals for understanding without explanation leads us to discuss the example of a purely classificatory biology: it turns out that such a science can give us understanding of the world through unification of the phenomena, even though it does not give us any explanations. The two types of understanding identified in this paper, while strictly separate, do have in common that both consist in seeing how the individual phenomena of the universe hang together. Explanations give us connections between the phenomena through the asymmetric, ‘vertical’ relation of determination; unifications give us connections through the symmetric, ‘horizontal’ relation of kinship. We then arrive at a general definition of understanding as knowledge of connections between the phenomena, and indicate that there might be more than two types of understanding.     

Acceptance,values, and probability

This essay makes a case for regarding personal probabilities used in Bayesian analyses of confirmation as objects of acceptance and rejection. That in turn entails that personal probabilities are subject to the argument from inductive risk, which aims to show non-epistemic values can legitimately influence scientific decisions about which hypotheses to accept. In a Bayesian context, the argument from inductive risk suggests that value judgments can influence decisions about which probability models to accept for likelihoods and priors. As a consequence, if the argument from inductive risk is sound, then non-epistemic values can affect not only the level of evidence deemed necessary to accept a hypothesis but also degrees of confirmation themselves.     

Bird, Kuhn, and positivism

I challenge Alexander Bird’s contention that the divergence between Kuhn’s views and recent philosophy of science is a matter of Kuhn having taken a wrong turn. Bird is right to remind us of Kuhn’s naturalistic tendencies, but these are not clearly an asset, rather than a liability. Kuhn was right to steer clear of extreme referential conceptions of meaning, since these court an unacceptable semantic scepticism. Although he eschewed the concepts of truth and knowledge as philosophers of science have tended to understand them, this doesn’t mean that, as Bird claims, Kuhn was a sceptic about scientific knowledge. Bird’s claim that recent philosophical naturalism represents a rejection of positivism far more thorough than Kuhn’s is problematic since, from a different perspective, this kind of naturalism can be seen to have inherited some equally important positivistic themes. Finally, it’s not clear that Kuhn should have endorsed a computational approach to the philosophy of science, such as connectionism, since such approaches may be more behaviouristic, and thus unacceptably positivistic, than the original cognitive revolution promised.     

Physicalism,realization, and structure

In the philosophy of mind and psychology, a central question since the 1960s has been that of how to give a philosophically adequate formulation of mind-body physicalism. A large quantity of work on the topic has been done in the interim. There have been, and continue to be, extensive discussions of the ideas of physicalism, identity, functionalism, realization, and constitution. My aim in this paper is a modest one: it is to get clearer about these ideas and some of their interrelations. After providing some background and history, I shall focus on two related topics: the distinction between a functional property and a structural one and the dispute over whether a realization account of the mental-physical relation provides a better physicalist account than a constitutional account.