Prolongation of the survival of skin grafts in mice by PUVA treatment

Summary The combined application of psoralen and UVA radiation to skin grafts induced a prolongation of the survival time of the grafts in mice. This was observed using the H-Y barrier, an allogeneic barrier without H-2 disparities, and a strong H-2 incompatible barrier. The effect is probably due to a reduction of antigen-presenting cells, or to other, unknown mechanisms.     

Prolongation of the survival of skin grafts in mice by PUVA treatment

The combined application of psoralen and UVA radiation to skin grafts induced a prolongation of the survival time of the grafts in mice. This was observed using the H-Y barrier, an allogeneic barrier without H-2 disparities, and a strong H-2 incompatible barrier. The effect is probably due to a reduction of antigen-presenting cells, or to other, unknown mechanisms.     

Prolongation of skin homograft survival by local intralymphatic radioisotope injections

Zusammenfassung Injektion von¹³¹I-Lipiodol oder¹¹¹Ag-Kolloid beim Kaninchen in ein Ohrlymphgefäss verzögert die Abstossung eines Hautlappen-Hormotransplantes am Ohre wesentlich. Bei der Untersuchung der Verteilung intralymphatisch verabreichter Radioisotopen in den einzelnen Geweben wurde festgestellt, dass etwa 50% des¹¹¹Ag-Kolloids, aber unter 10% des¹³¹I-Lipiodols von den regionären Lymphknoten aufgenommen wird und dass Lipiodol hauptsächlich im Lungengewebe, Ag-Kolloid in der Leber gespeichert wird.     

Bone induction evoked in mouse by xenogeneic grafts of the transitional epithelium

Résumé Des épithéliums de muqueuse vésicale de chien, de cobay et de hamster ont été greffés sur des souris préalablement traitées à l'acétate de cortisone. L'induction par ces greffes d'un cartilage et d'un tissu osseux prouve que l'inducteur d'ossification formé et libéré par ces épithéliums manque de spécificité générique. On a montré que le faible pourcentage de l'induction d'ossification est imputable à la faible capacité inductive de cet épithélium et non au manque de sensibilité du tissu conjonctif induit de la souris dans le système allogénique.

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We thank MissS. Skaryska, Mrs.E. Ruszkowska and Mr.T. Grabiski for technical assistance and Mr.B. Przybysz for preparing photographs.     

Modulation of humoral immunity in the mouse by means of grafts carrying reticulated polysaccharides]

Synthetic reticulated polysaccharides grafted with linear amino-acids or amines have been submitted to the test of localized hemolysis in gel (Jerne). Some of them show a statistically highly significant immuno-stimulating power in Mice.     

The role of sialic acid in determining the survival of circulating interferon

Summary Rabbit interferon has been extensively desialylated and its metabolic behaviour has been evaluated in the rabbit. The half-life of asialointerferon is significantly shorter than the native interferon and its urinary excretion becomes negligible. Moreover the rapid uptake of asialointerferon by the isolated and perfused rabbit liver, suggests a hitherto unsuspected catabolic pathway for this glycoprotein.This work was supported by a grant from the Consiglio Nazionale delle Ricerche, Roma (subproject on antiviral therapy), contract No. 76.00646.84).     

Daunomycin and skin allografts survival in mice

Riassunto L'effetto immunodepressivo della Daunomicina è stato studiato sulla sopravvivenza del trapianto cutaneo nel topo. La Daunomicina détermina un aumento del tempo di sopravvivenza del trapianto cutaneo, statisticamente significativo. Gli AA. discutono l'importanza che possono assumere le dosi, la via di somministrazione e lo schema di trattamento impiegato.     

Actions of interferon in tissue cultures harboring mouse leukemia virus

Zusammenfassung Das Virus der vesikulären Stomatitis verursacht Zellverschmelzung und Syncytienbildung in mit Mäuse-Leukämie-Virus infizierten Gewebskulturen. Interferon konnte diese Zellzerstörung in der Kultur nicht verhindern.

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This work was supported by U.S.P.H.S. research grant No. CA-7923 and award No. K3-CA-16747.     

Mast cells,tryptophan and 5-hydroxytryptamine in precancerous mouse skin

Zusammenfassung Nach Formaldehydfixation und Vorbehandlung mit dem Carcinogen DMBA oder Äthylphenylpropiolat (das nicht cancerogen oder co-cancerogen wirkt) wird in der Epidermis der Maus eine Tryptophanbedingte blaue Fluoreszenz gefunden. Die gelbe Fluoreszenz in den Mastzellen beruht auf 5-HT.