新螯合萃取剂DDBPMP的质谱特性研究

通过质谱分析法和理论计算首次对新螯合萃取剂DDBPMP的质谱特性进行了较系统的研究与报道,并对其基峰、主要碎片离子形成的机制和规律进行了研讨.     

新螯合萃取剂DDBPMP的质谱特性研究

通过质谱分析法和理论计算首次对新螯合萃取剂DDBPMP的质谱特性进行了较系统的研究与报道,并以其基峰,主要碎片离子形成的机制和规律进行了研讨。     

4,4''''－十二烷二酰基双PMP的质谱特性研究

通过质谱分析法和理论计算首次对新螯合萃取剂4，4'-十二烷二酰基双PMP的质谱特性进行了较系统的研究与报道，并对其基峰、主要碎片离子形成的机制和规律进行了研讨.     

4，4‘—十二烷二酰基双PMP的质谱特性研究

通过质谱分析法和理论计算首次对新螯合萃取剂4，4'－十二烷二酰基双PMP的质变特性进行了较系统的研究与报道，并对其基峰、主要碎片离子形成的机制和规律进行了研讨。     

一些方酸衍生物的质谱裂解规律研究

一些方酸衍生物的质谱裂解规律研究艾克蕙陈益钊李聚才李文藻郁陵庄（化学系）１引言氮氧方酸烷基酯（３－氨基－４－烷氧基－３－环丁烯二酮）（１～８）［１］和Ｎ－取代氮方酸（３－氨基－４－取代胺基－３－环丁烯二酮）（９～２７）［２］的结构特点是羰基和功能基都...     

酚醛树脂的热裂解气相色谱质谱研究

对热塑性苯酚甲醛树脂，对甲基苯酚甲醛树脂和叔丁基苯酚甲醛树脂进行热裂解－气相色谱－质谱研究，选择在６２０条件下进行热裂解，其裂解产物通过ＯＶ－１石英毛细管柱分离和质谱鉴定，获得了有关这三种酚醛树脂各自结构的特征信息。     

新化合物异二聚细辛醚的质谱学研究

应用质谱数据，探讨新化合物异二聚细辛醚的质谱裂解规律，对其质谱特征离子进行研究，为该新化合物提供质谱学基础。     

Study on fragmentation behavior of taxoids by tandem mass spectrometry

We have studied the fragmentation behavior of positive and negative ions of taxol and 6/8/6 type taxoids, the influence of different substituents on fragmentation, and the correlativity between fragmentation patterns and structure by MS/MS technique with different ionization methods such as FAB-MS, ESI-MS, etc. We have also investigated in detail the fragmentation of various molecular-related ions, such as [M+H]⁺, [M+Na]⁺ and [M-H]⁻ ions, and the formation pathways of characteristic fragment ions. It has been found that there exists some competing reaction between the loss of C-13 side chain and decomposition by loss of acetic acid. In addition, by comparing CID spectra obtained with low- and high-energy collision, it is seen that CID-MS/MS with low-energy collision is more suitable for the study of the structural analysis of small molecules and drug metabolites. The experimental results demonstrate that MS/MS spectra can reflect more effectively the slight difference of structure between the related compounds and their structural characteristic features than MS spectra, and can also provide a beneficial analysis basis for these kinds of compounds.     

牡荆素的飞行时间质谱

利用台式飞行时间质谱的中分辨本领,研究了牡荆素的电子轰击质谱的裂解规律,对裂解途径进行了完全的指认.5个主要碎片峰可以作为鉴定牡荆素的特征离子.其中2个对应于失水离子:m/z414(39%)和378(6%);另外3个分别为黄酮苄基离子m/z283(基峰),甙元离子m/z270(19%)和黄酮乙炔离子m/z294(8%).此外,3个低丰度的离子,即2个互补离子m/z165和m/z118以及黄酮乙醛离子m/z312,可以作为鉴定牡荆素的佐证.     

三聚氰胺的密度泛函理论研究

应用密度泛函理论(DFT)的B3LYP方法,在6-31G(d)基组水平上对三聚氰胺进行了研究。计算得到了分子的稳定构型,并对其进行了频率分析。然后利用Gaussview图形软件将频率分析数据转换为红外光谱。对红外光谱分析后发现,在400 cm-1～0 cm-1区域内分子的振动类型主要以分子内基团的整体摆动和胺基中C—H键的面外弯曲振动为主。在红外光谱的指纹区(1 333 cm-1～400 cm-1)谱线强度较弱,分子振动模式主要以弯曲振动为主,且存在七种分子的振动模式不具有红外活性。在光谱的特征谱带区(4 000 cm-1～1 333 cm-1),分子振动模式共有两种,即不对称伸缩振动和剪式振动。此外,整个红外光谱中振动峰的实际数目远小于简正振动的数目。     

Multifractal mass exponent spectrum of complex physiological time series

Physiological signal belongs to the kind of nonstationary and time-variant ones. Thus, the nonlinear analysis methods may be better to disclose its characteristics and mechanisms. There have been plenty of evidences that physiological signal generated by complex self-regulated system may have a fractal structure. In this work, we introduce a new measure to characterize multifractality, the mass exponent spectrum curvature, which can disclose the complexity of fractal structure from total bending degree of the spectrum. This parameter represents the nonlinear superpositions of the discrepancies of fractal dimension from all adjacent points in the curve and therefore solves the problem of original parameters for not fully reflecting the information of entire subsets in the fractal structure. The evaluations of deterministic fractal system Cantor measure validate that it is completely effective in exploring the complexity of chaotic series, and is also not affected by nonstability of the signal as well as disturbances of the noises. We then apply it to the analysis of human heart rate variability (HRV) signals and sleep electroencephalogram (EEG) signals. The experimental results show that this method can be better to discriminate cohorts under different physiological and pathological conditions. Compared with the indicator of singularity spectrum width, there are some improvements both on the computing efficiency and accuracy. Such conclusion may provide some valuable information for clinical diagnoses.     

质谱技术在蛋白质组学研究中的应用

随着蛋白质组学研究的迅速发展,质谱技术已成为应用于蛋白质组学研究中的强有力工具和核心技术。质谱技术的先进性在于为蛋白质组学研究提供的通量和分子信息。笔者重点概述了基于质谱路线的蛋白质组学研究,介绍了基于质谱的定量蛋白质组学﹑翻译后修饰蛋白质组学、定向蛋白质组学、功能蛋白质组学以及基于串联质谱技术的蛋白质组学数据解析的研究进展。     

螺旋藻藻蓝蛋白提取及稳定性试验

藻蓝蛋白可用于配制化妆品及各种天然食品或荧光探针标记．本研究用氯化钾溶菌酶法或冻融法破碎螺旋藻细胞壁,盐析,提取藻蓝蛋白,并对其理化特性进行了测定．表明酶法破壁适应于大量藻蓝蛋白制备,冻融法只适应于小量制备．提取率为１３％左右,提取藻蓝蛋白在４０℃以下及ｐＨ４．０～８．５之间表现稳定,４５℃以上有变色现象,荧光性减弱,糖溶液可提高藻蓝蛋白对热的稳定性,光照对藻蓝蛋白影响较小     

果实裂果的研究进展

本文对果实裂果的方式、种类、机制以及防止裂果的措施,做综合论述.     

离子吸附质谱中锂离子源的研制

研制并测试了一种用在离子吸附质谱中的锂离子源.这个离子源是通过在一个高真空管中,将Li2O·Al2O,·SiO2熔结在金属铼丝带上制备而成.考虑到离子源使用的耐久性及锂离子发射量,实验确定了最佳的铼丝温度为1 300℃.通过使用飞行时间质谱,大量的锂离子被检测到,表明研制的锂离子源能够用在质谱分析中.     

福州市游憩者活动的行为特征

通过实际问卷调查,分析在小尺度的游憩活动中,福州市游憩者的行为属性特征有游憩流动的空间特点,提出积极迎合游憩者的“感知”需求,合理定位及完善游憩地的主题环境,将有利于促进游憩流的稳定发展。