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(S)-3-p-methoxyphenyl-3-acetamidopropan-1-ol was isolated from cultures of an actinomycete (Streptomyces michiganensis). Its structural determination by spectroscopic means and its synthesis are described. 相似文献
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V. P. Arya R. S. Grewal J. David C. L. Kaul 《Cellular and molecular life sciences : CMLS》1967,23(7):514-515
Zusammenfassung 1-(5-Methyl-1-phenyl-4-pyrazolyl)-3-[4-(o-tolyl)-piperazinyl]-1-propanone (I; CIBA 1002-Go), senkt an normotonischen und hypertonischen Tieren den Blutdruck. Die Drucksenkung kann auf eine periphere Vasodilatation und eine Hemmung hypothalamischer oder medullärer Vasomotorenzentren bezogen werden. Ausserdem wirkt CIBA 1002-Go adrenolytisch.
Hydrochloride = CIBA 1002-Go. 相似文献
Hydrochloride = CIBA 1002-Go. 相似文献
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M. Katayama K. Kato H. Kimoto S. Fujii 《Cellular and molecular life sciences : CMLS》1995,51(7):721-724
Racemic 4,4,4-trifluoro-3-(indole-3-)butyric acid (TFIBA) has been synthesized and shown to inhibitAvena coleoptile elongation. (S)-(+)-TFIBA (fig. 1), which was prepared by an enzymatic method and markedly promotes root growth of Chinese cabbage, lettuce and rice plants, is a novel fluorinated plant growth regulator. Activity of the (S)-(+)-enantiomer of TFIBA was 10-fold greater than that of the (R)-(–)-enantiomer in the first two plant species and 5-fold greater in rice. 相似文献
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P. A. Barrett Elizabeth Beveridge D. Bull I. C. Caldwell P. J. Islip R. A. Neal N. C. Woods 《Cellular and molecular life sciences : CMLS》1982,38(3):338-339
Summary The biological properties of a novel compound 353C with high activity againstTrypanosoma cruzi, are described. The compound was about 10 times and 20 times more effective than either benznidazole or nifurtimox respectively, in producing radical cure in mice. 353C had a long half-life and showed anti-trypanosomal properties when given to mice at weekly intervals. 相似文献
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H. Nakamura K. Ishii Y. Yokoyama S. Motoyoshi C. Imazu M. Shimizu 《Cellular and molecular life sciences : CMLS》1979,35(3):369-370
Summary dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals. 相似文献
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A. Aiello E. Fattorusso S. Magno G. Misuraca E. Novellino 《Cellular and molecular life sciences : CMLS》1987,43(8):950-952
Summary 2-Amino-6-[(1'R,2'S)-1',2'-dihydroxypropyl]-3-methyl-pterin-4-one (1) has been isolated from the marine anthozoanAstroides calycularis; its structure was illustrated by spectral analyses including 2D-NMR and by partial synthesis.1 appears to possess cell-growth inhibiting activity.29 December 1986Work supported by C.N.R. (Progetto Finalizzato Chimica Fine e Secondaria) and by Ministero Pubblica Istruzione Italy. — Acknowledgments. Mass spectral data were provided by Servizio di Spettrometria di massa del C.N.R. e dell'Università di Napoli. The assistance of the staff is gratefully appreciated. Finally we would like to thank Prof. C. Pietropaolo for supplying chick embryo fibroblasts. 相似文献
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dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals. 相似文献
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M. Shimizu K. Yoshida T. Kadokawa N. Hatano J. Kuwashima K. Nakatsuji I. Nose M. Kobayashi 《Cellular and molecular life sciences : CMLS》1977,33(1):55-57
Summary 7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide (DU-717) is a new compound having sustained antihypertensive activity in a similar manner to that of hydrochlorothiazide. However, this compound shows neither diuretic nor hyperglycemic effect, being different from those of hydrochlorothiazide or diazoxide. 相似文献
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J Y Detaille C G Caillard S Mondot J C Louis L Julou 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(5):555-558
In the Dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (RS, SR) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. Furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. The first clinical studies of this compound have shown its usefulness in the treatment of ventricular and supraventricular arrhythmias. 相似文献
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R. K. Razdan A. J. Puttick B. A. Zitko G. R. Handrick 《Cellular and molecular life sciences : CMLS》1972,28(2):121-122
Zusammenfassung Die Synthese von (—)-1(7)-Tetrahydrocannabinol (THC) auf (—)-1(6) wird beschrieben. Das Hauptprodukt der oxidativen Zerstörung von (—)-1-THC ist Cannabinol. Beschleunigte Versuche der Luftoxidation von (—)-1-THC und (—)-1(6)-THC haben gezeigt, dass das letztere beständiger ist. Dieser Unterschied kann mit der Reaktivität des C3-benzylisch-allylischen Wasserstoffes in (—)-1-THC erklärt werden. 相似文献