Decrease of mast cells in regional lymph nodes in response to allogeneic antigens and syngeneic tumor antigens

Summary The absolute number of mast cells in regional lymph nodes decreases on the 5th day after stimulation by allogeneic lymphocytes and semisyngeneic leukaemic cells, despite the enlargement of stimulated lymph nodes. It is postulated that the reaction of lymphatic mast cells could be a sensitive test for tissue incompatibility, and probably also for the presence of tumor associated antigens.     

Increased relative growth rate of normal rat cells in vitro with crocetin

Summary The carotenoid crocetin (earlier found to increase relative growth of Walker 256 tumor cells and their radiosensitivity), is shown to increase the relative growth of normal Sprague-Dawley rat muscle derived cells in vitro, presumably by increasing oxygen transport.     

Treatment of spontaneous murine lymphomas with syngeneic lymphoid cells

Syngeneic thymus grafts and spleen cells were administered to thymectomized and intact (C57BL/1XA)F1 mice with spontaneous lymphomas. Their life span was prolonged significantly compared to untreated tumor-bearing controls. Dramatic clinical and histologic evidence of tumor regression was observed.     

Treatment of spontaneous murine lymphomas with syngeneic lymphoid cells

Summary Syngeneic thymus grafts and spleen cells were administered to thymectomized and intact (C57BL/1XA)F₁ mice with spontaneous lymphomas. Their life span was prolonged significantly compared to untreated tumor-bearing controls. Dramatic clinical and histologic evidence of tumor regression was observed.Supported by US P.H.S. grants Nos AM12151 and CA 15500.     

Eradication of lymphoma cells with allogeneic immune peritoneal cells

Zusammenfassung DBA/2 Mäuse wurden nach Injektionen mit SL2 Zellen mit allogenen, immunen und hyperimmunen Exsudat-Zellen aus dem Peritonealraum behandelt. Diese Behandlung ergab eine Eliminierung von 2×10⁶ SL2 Zellen.     

Immunological recovery of thymectomized and sham-thymectomized lethally irradiated mice reconstituted with syngeneic hone marrow cells

Summary Immunological functions of lethally irradiated mice reconstituted with syngeneic bone marrow cells recover after 5–6 weeks. In mice that had been thymectomized before irradiation and reconstitution, T-cell function is deficient but the B-cell function is preserved.Supported by subcontract No. 3322 from the Biology Division of Oak Ridge National Laboratory of the University of Tennessee, and by the Fulbright-Hays Program. Present address: Department of Physiology, University of Zagreb, Faculty ofOperated by the Union Carbide Corporation for the Department of Energy.     

Immunity and cancer: suppressor effect on the cytotoxic activity of lymphoid cells from animals carrying syngeneic tumors]

When it is tested in vitro, the cytotoxic action of lymphocytes from mice bearing a syngeneic tumour (T2) vary with the age of the graft. At a time when it is very low, the lymphoid cells are cultivated for 3 days and then can be fractionated in two subpopulations on a glass bead column: a cytotoxic "non adherent" group of cells and an "adherent" group that inhibits the activity of the first group when it is added to it.     

Fate of DNA-labelled bone-marrow cells from different mouse strains injected into syngeneic irradiated recipients

Zusammenfassung Knochenmarkszellen, durch Injektion von³H-Thymidin in syngenischen Spendern markiert, wurden in bestrahlte Empfänger von AKR-, C57 Bloder BALB/c-Mäuse injiziert, wobei grösste Aktivität in der Milz, dann im Knochenmark und im Thymus gefunden wurde. Aktivitätsverlust war während der 6tägigen Beobachtungsperiode in Milz und Knochenmark am stärksten. Auch die Regeneration und die Veränderungen der spezifischen Aktivität der DNA dieser Organe waren bei C 57 Bl- und BALB/c-Mäusen am ausgeprägtesten. Die markierten Spenderzellen im Thymus scheinen nicht von Zellen zu stammen, die über das Knochenmark dorthin transportiert wurden, sondern wurden unmittelbar vom Thymus aufgenommen.     

Effects of lithium chloride on normal and neoplastic cells in vitro

Résumé L'action du lithium (LiCl) a été étudiée comparativement sur des cellules néoplasiques humaines KB et normales de rein de singe. Les résultats obtenus démontrent que le LiCl en concentrations égales et supérieures à 5.10^–2 M entraîne une inhibition significative de la prolifération des deux types cellulaires. D'autre part, pour des temps d'exposition supérieurs à 24h, cet effet cytoinhibiteur s'accompagne d'une diminution de la quantité des RNA cytoplasmiques. Ces effets du LiCl apparaissent sélectifs par rapport à ceux du NaCl utilisés en concentrations équimoléculaires.     

Immunological recovery of thymectomized and sham-thymectomized lethally irradiated mice reconstituted with syngeneic bone marrow cells.

Immunological functions of lethally irradiated mice reconstituted with syngeneic bone marrow cells recover after 5--6 weeks. In mice that had been thymectomized before irradiation and reconstitution, T-cell function is deficient but the B-cell function is preserved.