共查询到20条相似文献，搜索用时 31 毫秒
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Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross 总被引：4，自引：0，他引：4
B Robert P Barton A Minty P Daubas A Weydert F Bonhomme J Catalan D Chazottes J L Guénet M Buckingham 《Nature》1985,314(6007):181-183
The introduction of cloned probes to follow the segregation of DNA restriction fragment length polymorphisms (RFLPs) has led to a revival of mendelian genetics in attempts to map the human genome. In the mouse, however, it has often proved difficult to detect an RFLP with a DNA probe between different inbred strains of the laboratory mouse. To circumvent this problem, we have used two species, Mus musculus domesticus and Mus spretus which interact as sympatric species but can be interbred under laboratory conditions. Because of the relative evolutionary distance between these species, they exhibit polymorphism at many more loci than do different strains of the usual M. m. domesticus laboratory mouse. This is also observed at the DNA level when the sizes of restriction fragments encoding a specific gene are compared. We have used these RFLPs between M. m. domesticus and M. spretus to follow the segregation of genes encoding different isoforms of myosin alkali light chains in the backcross progeny between these species and to compare this with that of other contractile protein genes. No linkage between these genes was observed. 相似文献
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SIMMONS RT 《Nature》1957,179(4567):970-971
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在310.15 K,pH=7.0的生理条件下,利用微量热法研究了牛血清白蛋白与Cu2 ,Ca2 相互作用,得到牛血清白蛋白与Cu2 的结合数为1;摩尔结合焓为-22.83 kJ·mol-1,摩尔结合自由能和熵分别为-66.024 kJ·mol-1和654.66 J·mol-1,而牛血清白蛋白与Ca2 则表现出较弱的相互作用. 相似文献
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记(G)为有限群G的元素的阶的集合.假定L为有限单群Cp(2),G为满足条件(G)=(L)的任意一个有限群,则群G含有唯一一个非交换的合成因子,其同构于单群L;也就是说,单群Cp(2)是拟可刻画的.这个结果同时也证实了施武杰提出的猜想对于单群Cp(2)是成立的. 相似文献
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High mobility group (HMG) proteins are abundant non-histone proteins in the nuclei of eukaryocytes. It has been shown that HMG proteins may play important roles in the structure and function of chromatin. In the present study, thebinding of HMG proteins (HMG1/2 and HMG14/17) to the human ε-globin gene promoter (ε-promo- ter, -177-+1 bp) has been examined by using both the in vitro nucleosome reconstitution and the electrophoresis mobility shift assay (EMSA). We found that HMG1/2 proteins could bind to the naked ε-promoter DNA, however, HMG14/17 could not. Using the in vitro nucleosome recons- titution, we revealed that HMG14/17 could bind to the mononucleosome reconstituted in vitro with ε-promoter,whi- le HMG1/2 could not. Those results indicate that the binding of HMG proteins to ε-promoter is dynamic as the nucleo- some assembling and disassembling. Wespeculated that this selective binding of HMG proteins to ε-promoter might playa critical role in the regulation of ε-globin gene expression. 相似文献
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利用Grbner-Shirshov基和Anick方法,构造了量子包络代数Uq(sl2)的Anick分解。作为一个应用,还讨论了Uq(sl2)的一些同调性质和Poincaré级数。 相似文献
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用荧光光谱、紫外光谱和圆二色谱法研究了抗凝血药物华发灵钠与人血清白蛋白(HSA)的相互作用.初步确定华法灵钠对人血清白蛋白的荧光产生猝灭现象,猝灭方式为静态,并计算了二者形成化合物的结合常数K和结合位点数n.根据不同温度下的热力学函数,确定了华发灵钠与人血清白蛋白的相互作用力类型为氢键和范德华力.发现华法灵钠的存在明显改变人血清白蛋白的构象,并讨论了华发灵钠使人血清白蛋白构象发生变化的可能原因. 相似文献
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