Metabolic restoration in rat liver after partial hepatectomy

Zusammenfassung Es zeigt sich während des frühen Regenerationsstadiums bei der teilweise hepatektomierten Rattenleber, dass ein Anstieg im Galaktose-Metabolismus mit gleichzeitiger Abnahme seiner Hemmung durch Ethanol einhergeht. Nach vollständiger Geweberegeneration kehrt der normale Metabolismus zurück.

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I wish to thank ProfessorJ. H. Quastel for providing me with the facilities and for his encouragement during my work at McGill University, Montreal (Canada).     

Effect of dexamethasone on Fc gamma receptor expression in foetal and neonatal rat gut

When injected into 12-day-old suckling rats, dexamethasone caused a precocious disappearance of Fc gamma receptors from enterocytes of the proximal small intestine. However, dexamethasone appeared to be necessary for the maintenance or production of such receptors in foetal rat gut cultured in vitro.     

Effect of clofibrate on the phospholipid biosynthesis in rat liver

Summary The effect of clofibrate on rat liver phospholipid biosynthesis was studied using³²P as a precursor. Phospholipid classes, levels and specific radioactivity were evaluated. Significant increases in levels of phosphatidylethanolamine and phosphatidylcholine were found and could account for the observed increase in total phospholipids. Specific activity of phosphatidylserine increased and that of phosphatidylethanolamine decreased. This fact suggests that clofibrate seems to alter the systems engaged in the transformation occurring within the different classes of phospholipids but not the de novo biosynthesis.     

Leucine aminopeptidase in the foetal kidney of the rat

Zusammenfassung Histochemisch demonstrierbare Leucinaminopeptidase erschien in den letzten Tagen der Schwangerschaft in einzelnen Gruppen von Tubuli der Rinde der fötalen Rattenniere. Der grösste Teil der Rinde und das Mark erwiesen sich als negativ. Nach der Geburt verbreitete sich das Ferment über die ganze Rinde und vermehrte seine Aktivität stark.     

Effects of placental lesions on foetal growth in rats

Résumé Un état d'insuffisance placentaire a été produit chez la ratte au moyen de lésions électrolytiques effectuées au 17^e jour de gestation. Le poids corporel ainsi que le poids du foie des foetus, au 21^e jour de la grossesse, présentèrent une diminution; tandis que le poids du cerveau en relation à celui du foie avait augmenté. Ces résultats indiquent que les foetus ainsi traités subissent un retardement de croissance par rapport aux témoins de même âge.

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Acknowledgments. The author wishes to thank Dr.D. G. Montemurro for the use of the electrolytic apparatus and Mr.N. Falconer and Mr.J. Krcek for their technical assistance.     

Observations upon the mast cells of rat foetal tissues

Résumé Dans les études physiologiques récentes, il est dit que l'histamine foetale se montre plusieurs jours avant l'apparition des mastocytes dans les tissus foetaux. Le présent travail démontre que les mastocytes apparaissent plus tôt et sont plus répandus qu'on ne le supposait. Ces constatations confirment d'anciennes observations apparemment oubliées.     

Effect of clofibrate on the phospholipid biosynthesis in rat liver.

The effect of clofibrate on rat liver phospholipid biosynthesis was studied using 32P as a precursor. Phospholipid classes, levels and specific radioactivity were evaluated. Significant increases in levels of phosphatidylethanolamine and phosphatidylcholine were found and could account for the observed increase in total phospholipids. Specific activity of phosphatidylserine increased and that of phosphatidylethanolamine decreased. This fact suggests that clofibrate seems to alter the systems engaged in the transformation occurring within the different classes of phospholipids but not the de novo biosynthesis.     

Effect of acetone on VLDL secretion by the isolated rat liver

Summary High acetone levels occur in uncontrolled diabetes and after isopropanol administration to rats. In both conditions, very low density lipoproteins (VLDL) secretion is depressed. Acetone, however, failed to affect the VLDL secretion rate by the isolated perfused rat liver, suggesting that this metabolite is not involved in impaired VLDL production in diabetes and after isopropanol administration.     

Effect of dicumarol on rat liver slice glycoprotein synthesis

Résumé Dans les tranches de foie, le dicumarol et la warfarine empêchent la glycosamine¹⁴C de s'incorporer aux glycoprotéines. Cette inhibition dépend de la dose employée. La glucosamine-¹⁴C a été incorporée par des glycoprotéines et des glycolipides et elle se produisit au cours d'expériences d'une durée de 21/2 h. L'inhibition par le Dicumarol de l'incorporation de la glucosamine par les glycoprotéines et les glycolipides dans des tranches de foie n'a pas pu être expliquée par un effet de l'anticoagulant sur le métabolisme de la glucosamine en composés solubles dans les acides et adsorbés par le charbon de bois.     

Effect of clofibrate on the enzyme activity of rat liver plasma membranes

Summary The activity of 3 plasma membranes marker enzymes (5-nucleotidase, Mg⁺⁺-ATPase and alkaline phosphodiesterase-I) was determined in plasma membranes isolated from liver of control and of clofibrate-treated rats. A complete identity of plasma membranes enzyme activity in the 2 groups of experimental animals was observed for the 3 enzymes studied.     

Effect of acetone on VLDL secretion by the isolated rat liver.

High acetone levels occur in uncontrolled diabetes and after isopropanol administration to rats. In both conditions, very low density lipoproteins (VLDL) secretion is depressed. Acetone, hoever, failed to affect the VLDL secretion rate by the isolated perfused rat liver, suggesting that this metabolite is not involved in impaired VLDL production in diabetes and after isopropanol administration.     

Effect of PGE1 on lipogenesis in perfused rat liver

Summary In perfused livers of 24 hour-fasted rats, PGE₁ (prostaglandin E₁) infused continuously into the perfusate, was found to cause a 45% increase in the incorporation of 1-¹⁴C acetate into liver fatty acids. PGE₁ was found to have no effect, however, on the activity of the key lipogenic enzymes.     

Effect of cerium on drug metabolizing activity in rat liver

Zusammenfassung Es wird gezeigt, dass i.v. injiziertes Cerium (2 mg/kg) eine hemmende Wirkung auf den Stoffwechsel von Arzneien in der Rattenleber hat.     

Age-dependent increase of thermal stability of in situ chromatin of rat liver and its reversal after hepatectomy

Summary An age-dependent increase of thermal stability of DNA in situ has been demonstrated in rat liver by means of microfluorimetry, which was reversed to a great extent in old regenerated liver.These authors are guests for collaboration at Ancona (Italy) till July, 1976. Their permanent address: Biological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary.