共查询到20条相似文献,搜索用时 15 毫秒
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Résumé En milieu de Krebs-Ringer oxygéné et glucosé, les coupes de cortex cérébral de Rat accumulent les acides aminés contre un gradient de concentration. L'anoxie, l'exclusion du substrat, et les inhibiteurs métaboliques inhibent cette accumulation. Parmi les substrats de la chaîne glycolytique et du cycle de Krebs étudiés, le succinate et le fumarate donnent les niveaux d'accumulation les plus réduits. On observe très généralement une corrélation entre la teneur des composés phosphorylés riches en énergie, et l'accumulation active des acides aminés. 相似文献
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Zusammenfassung Es wird festgestellt, dass einige peptidische Fragmente des Oxytocins dessen Abbau durch Schwangerenserum, Mäusepankreas und Mäuseleber hemmen. 相似文献
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Riassunto Nè il Triton W R 1339 nè l'acido feniletilacetico sono capaci di modificare significativamente la biosintesi di colesterolo da parte di omogenati di fegato di ratto incubati a 37°C. 相似文献
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Zusammenfassung Leberkatalase wird durch (Arylthio)-acetohydroxamsäure gehemmt. I60 Werte: 4.5·10–3 to 1,0·10–4
M.p-Bromoderivat (pI50=4.0) zeigt die stärkste Hemmung. Substitution in der Para-Stellung des Benzol Ringes verursacht eine zunehmende Hemmung in der Reihenfolge: CH3OCH3ClBr. Es wird vermutet, dass sich der Hemmstoff nicht mit dem aktiven Zentrum des Ferments verbindet. 相似文献
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M. Garcia-Gracia J. Gervas-Camacho F. V. DeFeudis 《Cellular and molecular life sciences : CMLS》1978,34(2):227-228
Summary I.p. injections of desipramine-HCL (100 mg/kg) produced decreases in the contents of several amino acids of mouse brain after 1 h. Using a 10–100 mg/kg range of doses, these effects appeared to be dose-dependent for -alanine and aspartate. These changes may be due, in part, to a decrease in cerebral oxidative metabolism (Krebs cycle activity) which occurs secondarily to desipramine-induced hypothermia.This study was supported by Centro Ramón y Cajal and Fundacion Juan March. 相似文献
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I.p. injections of desipramine-HCl (100 mg/kg) produced decreases in the contents of several amino acids of mouse brain after 1 h. Using a 10-100 mg/kg range of doses, these effects appeared to be dose-dependent for alpha-alanine and aspartate. These changes may be due, in part, to a decrease in cerebral oxidative metabolism (Krebs cycle activity) which occurs secondarily to desipramine-induced hypothermia. 相似文献
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M. Goldstein A. J. Friedhoff C. Simmons N. N. Prochoroff 《Cellular and molecular life sciences : CMLS》1959,15(7):254-256
Zusammenfassung Homogenate aus Gehirn wurden mit 3-Hydroxytyramine-1-C14 inkubiert. Als Stoffwechselprodukt wurde aus der sauren Fraktion radioaktive 3,4-Dioxyphenylessigsäure isoliert. Aus der basischen Fraktion wurden drei radioaktive Zonen papierchromatographisch isoliert. Die erste Zone konnte noch nicht identifiziert werden. Die zweite wurde als 3-Hydroxytyramin und die dritte als 3-Methoxytyramin erkannt. Die mögliche Rolle der Stoffwechselprodukte von 3-Hydroxytyramin beim Parkinson-Syndrom wird diskutiert.
This study was supported in part by United States Public Health Service Grant M 2717.The authors are grateful toR. J. Floody, M. D. of Hoffmann-La Roche Inc., for providing us with iproniazid. 相似文献
This study was supported in part by United States Public Health Service Grant M 2717.The authors are grateful toR. J. Floody, M. D. of Hoffmann-La Roche Inc., for providing us with iproniazid. 相似文献
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G. Tomita 《Cellular and molecular life sciences : CMLS》1967,23(1):25-26
Zusammenfassung Durch Gegenwart von Co++ oder J– oder Tryptophan oderp-Phenylendiamin wird die durch Riboflavin sensibilisierte Photoinaktivierung der Taka-Amylase A stark gehemmt. Die möglichen Mechanismen der Hemmungswirkung dieser Inhibitoren werden diskutiert. 相似文献
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Summary From 4 serum aminopeptidases (2 of pregnant and 2 of nonpregnant women's sera), the placental lysosomal (mol. wt 320,000) splits Lys-NAp only. B-Cys-NAp is hydrolyzed from the both placental enzymes, i.e. lysosomal and microsomal (mol. wt 145.000) AP. Ala-NAp is split by both nonpregnant serum AP more readily than Leu-NAp. 相似文献
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From 4 serum aminopeptidases (2 of pregnant and 2 of nonpregnant women's sera), the placental lysosomal (mol. wt 320,000) splits Lys-NAp only. B-Cys-NAp is hydrolyzed from the both placental enzymes, i.e. lysosomal and microsomal (mol. wt 145,000) AP. Ala-NAp is split by both nonpregnant serum AP more readily than Leu-NAp. 相似文献
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Summary Several branched fatty acids including an antiepileptic agent nDPA were tested as potential inhibitors of high affinity uptake of GABA by brain slices and synaptosomes. Only three compounds (2-butyl-3-propylhexanoic acid, 5-propyloctanoic acid, 2-propylpenten-2-oic acid) were found to be relatively weak inhibitors of the uptake system. There was no correlation between anticonvulsant properties of the branched fatty acids and their potencies as inhibitors of high affinity uptake of GABA. 相似文献
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Riassunto La comparsa, da digiuno, di una nuova attività arginasica nel fegato di pulcino del ceppo Nuova Livornese Dorata, è associata al decrescere della incorporazione di arginina nelle proteine epatiche. Il fenomeno potrebbe avere interesse nella regolazione della sintesi proteica.
Supported by grants from the Italian Consiglio Nazionale delle Ricerche (Impresa di Enzimologia) and from the National Institutes of Health No. GM 12291. 相似文献
Supported by grants from the Italian Consiglio Nazionale delle Ricerche (Impresa di Enzimologia) and from the National Institutes of Health No. GM 12291. 相似文献
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There was a significant fall in cAMP levels after administration of TFP or ketalar. Different amounts of cAMP were present in different regions of rat brain. Concentrations of cAMP in different regions of the rat brain were found to decrease in the following order: cerebrum > thalamus with hypothalamus > midbrain > hippocampus > cerebral cortex. 相似文献
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Summary There was a significant fall in cAMP levels after administration of TFP or ketalar. Different amounts of cAMP were present in different regions of rat brain. Concentrations of cAMP in different regions of the rat brain were found to decrease in the following order: cerebrum > thalamus with hypothalamus > midbrain > hippocampus > cerebral cortex.Conducted under ocntract No 10.4.2 with the Polish Academy of Science. 相似文献
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C. E. Sekeris 《Cellular and molecular life sciences : CMLS》1966,22(4):250-251
Zusammenfassung
p-Hydroxy und 3,4-Dihydroxy-phenylbrenztraubensäure hemmt die von Phenoloxydase katalysierte Umwandlung von Tyrosin in Melanin unter Anhäufung von Zwischenprodukten. Das Ergebnis wird im Zusammenhang mit der Pathogenese nervöser Störungen diskutiert. 相似文献