On broken symmetries and classical systems

Baker (2011) argues that broken symmetries pose a number of puzzles for the interpretation of quantum theories—puzzles which he claims do not arise in classical theories. I provide examples of classical cases of symmetry breaking and show that they have precisely the same features that Baker finds puzzling in quantum theories. To the extent that Baker is correct that the classical cases pose no puzzles, the features of the quantum case that Baker highlights should not be puzzling either.     

Against dogma: On superluminal propagation in classical electromagnetism

It is deeply entrenched dogma that relativity theory prohibits superluminal propagation. It is also experimentally well-established that under some circumstances, classical electromagnetic fields propagate through a dielectric medium with superluminal group velocities and superluminal phase velocities. But it is usually claimed that these superluminal velocities do not violate the relativistic prohibition. Here I analyze electromagnetic fields in a dielectric medium within a framework for understanding superluminal propagation recently developed by Geroch, 1996, Geroch, 2011 and elaborated by Earman (2014). I will argue that for some parameter values, electromagnetic fields do propagate superluminally in the Geroch–Earman sense.     

On the time reversal invariance of classical electromagnetic theory

David Albert claims that classical electromagnetic theory is not time reversal invariant. He acknowledges that all physics books say that it is, but claims they are “simply wrong” because they rely on an incorrect account of how the time reversal operator acts on magnetic fields. On that account, electric fields are left intact by the operator, but magnetic fields are inverted. Albert sees no reason for the asymmetric treatment, and insists that neither field should be inverted. I argue, to the contrary, that the inversion of magnetic fields makes good sense and is, in fact, forced by elementary geometric considerations. I also suggest a way of thinking about the time reversal invariance of classical electromagnetic theory—one that makes use of the invariant four-dimensional formulation of the theory—that makes no reference to magnetic fields at all. It is my hope that it will be of interest in its own right, Albert aside. It has the advantage that it allows for arbitrary curvature in the background spacetime structure, and is therefore suitable for the framework of general relativity. The only assumption one needs is temporal orientability.     

On the necessary truth of the laws of classical mechanics

The idealization of primitive mechanical experience is shown to lead to four mutually related formulations of classical mechanics based on connections, action at a distance, stresses, and collisions. For a given structure of spacetime and a given characterization of mechanical systems, fundamental laws (including Newton's law of acceleration and d’Alembert's principle) are derived from a few general principles regarding the comprehensibility of motion. Special emphasis is placed on the “secular principle,” according to which the evolution of a system at the relevant time scale should not depend on finer details of the applied forces.     

On conceptual issues in classical electrodynamics: Prospects and problems of an action-at-a-distance interpretation

Some conceptual issues in the foundations of classical electrodynamics concerning the interaction between particles and fields have recently received increased attention among philosophers of physics. After a brief review of the debate, I argue that there are essentially two incompatible solutions to these issues corresponding to F.A. Muller's distinction between the extension and the renormalization program. Neither of these solutions comes free of cost: the extension program is plagued with all problems related to extended elementary charges, the renormalization program works with point charges but trades in the notorious divergences of the field energies. The aim of this paper is to bring back into the discussion a third alternative, the action-at-a-distance program, which avoids both the riddles of extended elementary charges as well as the divergences although it admittedly has other problems. It will be discussed, why action-at-a-distance theories are actually not a far cry from particle–field theories, and I will argue that the main reasons for rejecting action-at-a-distance theories originate in certain metaphysical prejudices about locality and energy conservation. I will broadly suggest how these concepts could be adapted in order to allow for action at a distance.     

Newton and the classical theory of probability

Summary Probabilistic ideas and methods from Newton's writings are discussed in § 1: Newton's ideas pertaining to the definition of probability, his probabilistic method in chronology, his probabilistic ideas and method in the theory of errors and his probabilistic reasonings on the system of the world. Newton's predecessors and his influence upon subsequent scholars are dealt with in §2: beginning with his predecessors the discussion continues with his contemporaries Arbuthnot and De Moiver, then Bentley. The section ends with Laplace, whose determinism is seen as a development of the Newtonian determinism.An addendum is devoted to Lambert's reasoning on randomness and to the influence of Darwin on statistics. A synopsis is attached at the end of the article.Abbreviations PT abridged Philosophical Transactions of the Royal Society 1665–1800 abridged. London, 1809 - Todhunter I. Todhunter, History of the mathematical theory of probability, Cambridge, 1865 To the memory of my mother, Sophia Sheynin (1900–1970)     

Emergence and topological order in classical and quantum systems

There has been growing interest in systems in condensed matter physics as a potential source of examples of both epistemic and ontological emergence. One of these case studies is the fractional quantum Hall state (FQHS). In the FQHS a system of electrons displays a type of holism due to a pattern of long-range quantum entanglement that some argue is emergent. Indeed, in general, quantum entanglement is sometimes cited as the best candidate for one form of ontological emergence. In this paper we argue that there are significant formal and physical parallels between the quantum FQHS and classical polymer systems. Both types of system cannot be explained simply by considering an aggregation of local microphysical properties alone, since important features of each are globally determined by topological features. As such, we argue that if the FQHS is a case of ontological emergence then it is not due to the quantum nature of the system and classical polymer systems are ontologically emergent as well.     

Coexistence of peptides with classical neurotransmitters

In the present article the fact is emphasized that neuropeptides often are located in the same neurons as classical transmitters such as acetylcholine, 5-hydroxy-tryptamine, catecholamines, gamma-aminobutyric acid (GABA) etc. This raises the possibility that neurons produce, store and release more than one messenger molecule. The exact functional role of such coexisting peptides is often difficult to evaluate, especially in the central nervous system. In the periphery some studies indicate apparently meaningful interactions of different types with the classical transmitter, but other types of actions including trophic effects have been observed. More recently it has been shown that some neurons contain more than one classical transmitter, e.g. 5-HT plus GABA, further underlining the view that transfer of information across synapses may be more complex than perhaps hitherto assumed.     

Chance,determinism and the classical theory of probability

This paper situates the metaphysical antinomy between chance and determinism in the historical context of some of the earliest developments in the mathematical theory of probability. Since Hacking's seminal work on the subject, it has been a widely held view that the classical theorists of probability were guilty of an unwitting equivocation between a subjective, or epistemic, interpretation of probability, on the one hand, and an objective, or statistical, interpretation, on the other. While there is some truth to this account, I argue that the tension at the heart of the classical theory of probability is not best understood in terms of the duality between subjective and objective interpretations of probability. Rather, the apparent paradox of chance and determinism, when viewed through the lens of the classical theory of probability, manifests itself in a much deeper ambivalence on the part of the classical probabilists as to the rational commensurability of causal and probabilistic reasoning.     

Coexistence of peptides with classical neurotransmitters

Summary In the present article the fact is emphasized that neuropeptides often are located in the same neurons as classical transmitters such as acetylcholine, 5-hydroxy-tryptamine, catecholamines, -aminobutyric acid (GABA) etc. This raises the possibility that neurons produce, store and release more than the one messenger molecule. The exact functional role of such coesisting peptides is often difficult to evaluate, especially in the central nervous system. In the periphery some studies indicate apparently meaningful interactions of different types with the classical transmitter, but other types of actions including trophic effects have been observed. More recently it has been shown that some neurons contain more than one classical transmitter, e.g. 5-HT plus GABA, further underlining the view that transfer of information across synapses may be more compex than perhaps hitherto assumed.     

Molecular cloning and analysis of the protein modules of aggrecans

The large aggregating chondroitin sulfate proteoglycan of cartilage, aggrecan, has served as a prototype of proteoglycan structure. Molecular cloning has elucidated its primary structure and revealed both known and unknown domains. To date the complete structures of chicken, rat and human aggrecans have been deduced, while partial sequences have been reported for bovine aggrecan. A related proteoglycan, human versican, has also been cloned and sequenced. Both aggrecan and versican have two lectin domains, one at the amino-terminus which binds hyaluronic acid and one at the carboxyl-terminus whose physiological ligand is unknown. Both lectins have homologous counterparts in other types of proteins. Within the aggrecans the keratan sulfate domain may be variably present and also has a prominent repeat in some species. The chondroitin sulfate domain has three distinct regions which vary in their prominence in different species. The complex molecular structure of aggrecans is consistent with the concept of exon shuffling and aggrecans serve as suitable prototypes for comprehending the evolution of multi-domain proteins.     

A forecasting comparison of classical and Bayesian methods for modelling logistic diffusion

A Bayesian procedure for forecasting S‐shaped growth is introduced and compared to classical methods of estimation and prediction using three variants of the logistic functional form and annual times series of the diffusion of music compact discs in twelve countries. The Bayesian procedure was found not only to improve forecast accuracy, using the medians of the predictive densities as point forecasts, but also to produce intervals with a width and asymmetry more in accord with the outcomes than intervals from the classical alternative. While the analysis in this paper focuses on logistic growth, the problem is set up so that the methods are transportable to other characterizations of the growth process. Copyright © 2001 John Wiley & Sons, Ltd.     

Interpretation neutrality in the classical domain of quantum theory

I show explicitly how concerns about wave function collapse and ontology can be decoupled from the bulk of technical analysis necessary to recover localized, approximately Newtonian trajectories from quantum theory. In doing so, I demonstrate that the account of classical behavior provided by decoherence theory can be straightforwardly tailored to give accounts of classical behavior on multiple interpretations of quantum theory, including the Everett, de Broglie–Bohm and GRW interpretations. I further show that this interpretation-neutral, decoherence-based account conforms to a general view of inter-theoretic reduction in physics that I have elaborated elsewhere, which differs from the oversimplified picture that treats reduction as a matter of simply taking limits. This interpretation-neutral account rests on a general three-pronged strategy for reduction between quantum and classical theories that combines decoherence, an appropriate form of Ehrenfest׳s Theorem, and a decoherence-compatible mechanism for collapse. It also incorporates a novel argument as to why branch-relative trajectories should be approximately Newtonian, which is based on a little-discussed extension of Ehrenfest׳s Theorem to open systems, rather than on the more commonly cited but less germane closed-systems version. In the Conclusion, I briefly suggest how the strategy for quantum-classical reduction described here might be extended to reduction between other classical and quantum theories, including classical and quantum field theory and classical and quantum gravity.     

Influence of classical immunosuppressants on spleen colony formation in mice

Zusammenfassung Nachweis eines Hemmeffektes immunosupressiver Mittel (Cortison, Cyclophosphamide und Immuran) bei Mäusen nach UV-Bestrahlung auf die hämopoetische Regeneration (Milzkolonien und Knochenmarkzellen).     

Purification, cloning and characterisation of odorant- and pheromone-binding proteins from pig nasal epithelium

Two distinct classes of lipocalin isoforms (OBP-IIs and OBP-IIIs) were purified and identified from porcine nasal mucosa of male and female individuals. Using primers designed on their N-terminal sequence, the complete primary structures of the mature polypeptides were determined. Mass spectrometry analysis confirmed the identity of the cDNA-derived sequences and provided information regarding their post-translational modifications. These species strongly resemble a lipocalin expressed by von Ebner's gland and salivary lipocalins carrying sex-specific pheromones secreted only by the boar's submaxillary glands. Both OBP-IIs and OBP-IIIs present two cysteines paired in a disulphide bond; the remaining residues occur in a reduced form. In addition, OBP-IIIs are heavily glycosylated and markedly different in their glycan moiety from the salivary lipocalins. A three-dimensional model is proposed based on protein species with known structure. Like salivary lipocalins, OBP-IIIs bind a number of odorant molecules, with highest affinity for the specific pheromone 5alpha-androst-16-en-3-one. The high similarity between OBPs from the nasal area and lipocalins from secretory glands suggests a common function in binding the same pheromonal ligands, the latter carrying chemical messages into the environment the former delivering them to specific receptors.     

New biologically active peptide system in serum related to classical anaphylatoxin

Zusammenfassung Produkte einer enzymatischen Reaktion mit klassischem Anaphylatoxin als Substrat, das als Peptidkomponente des leukotaktischen Systems identifiziert und kristallisiert wurde, können als Mediatoren verschiedene Typen des protrahierten Schocks verursachen.

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First to be presented at: International Congress of Immunology, Washington, D.C. (1971).

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The author thanks Mrs.Irmgard Ernenputsch for expert technical assistance. He is indebted to Dr.C. Glanzmann, and Prof.F. Hahn, Freiburg, Dr.Vera Stecher and Prof.Ernst Sorkin, Schweizerisches Forschungsinstitut, Davos/Switzerland, for their generous experimental support in measuring biological activities and for many critical discussions.