Emericid,a new polyether antibiotic fromStreptomyces hygroscopicus (DS 24 367)

Summary Emericid is a new polyether polycyclic ionophore antibiotic excreted byStreptomyces hygroscopicus (DS 24 367). Active in vitro against Gram-positive bacteria, it is ineffective in vivo. At a 0.006–0.02% level in the diet it protects chickens and rabbits against coccidiosis.From a recent paper byN. Otake (Tetrahedron Lett.1970, 4147) emericid and lonomycin would be identical.     

Emericid, a new polyether antibiotic from Streptomyces hygroscopicus (DS 24 367).

Emericid is a new polyether polycyclic ionophore antibiotic excreted by Streptomyces hygroscopicus (DS 24 367). Active in vitro against Gram-positive bacteria, it is ineffective in vivo. At a 0.006-0.02% level in the diet it protects chickens and rabbits against coccidiosis.     

Nosiheptide,a sulfur-containing peptide antibiotic isolated fromStreptomyces actuosus 40037

Summary Nosiheptide (9671 R.P.) isolated fromStreptomyces actuosus 40037 (NRRL 2954) is a sulfur-containing polypeptidic antibiotic, quite different from all the other members of this family. Very active in vitro against gram-positive bacteria, it is inactive in vivo in experimentally infected mice. Not toxic, even at high dose, it may be used as a feed additive for chickens and pigs and it shows a favourable effect on the growth and conversion index.     

Neuromuscular blocking activity of dibekacin,a new semisynthetic aminoglycoside antibiotic

Summary Dibekacin possesses the untoward effect of producing a neuromuscular blockade. Neostigmine is unable to reverse the neuromuscular blockade produced by dibekacin. Calcium has not only the ability to restore the neuromuscular transmission but also to exert protective action against the neuromuscular blocking activity of dibekacin.     

Thermozymocidin new antifungal antibiotic from a thermophilic eumycete

Riassunto È stato isolato un nuovo antibiotico, denominato termozimocidina, attivo contro lieviti e funghi filamentosi, prodotto in coltura sommersa da un eumicete termofilo. Vengono presentate le principali propietà chimiche, fisiche e biologiche che ne permettono la sua caratterizzazione.     

A new actinomycin-like antibiotic produced by a mutant strain ofStreptomyces indicus

Zusammenfassung Aus einer Mutante vonStreptomyces indicus Chakrabarty sp. nov. wurde das neue Antibiotikum MT-10 (orange-gelbe Kristalle) isoliert. Die antibakterielle und antifungische Aktivität wurde untersucht und festgestellt, dass MT-10 mit Actinomycin D verwandt ist.     

Partricin methyl ester,a semisynthetic polyene antibiotic

Zusammenfassung Es wurde der Methylester von Partricin, eines polyenischen Antibiotikums, hergestellt. Das Produkt zeigte eine gesteigerte Aktivität gegen Hefen und eine verminderte Toxizität.     

The structure of a novel antitumor antibiotic,saframycin A

Summary A structure is assigned to saframycin A, a novel antitumor antibiotic fromStreptomyces lavendulae No. 314, on the basis of¹³C NMR-spectral data.     

The total synthesis of racemic cryptosporiopsin,a fungitoxic antibiotic

Résumé L'antibiotique cryptosporiopsine, produit métabolique deSporormia affinis ainsi que d'une espèce deCryptosporiopsis a été synthétisé à partir de la dihydrocryptosporiopsine synthétique.     

A new antifungal antibiotic produced byStreptomyces sp. Ac2435

Zusammenfassung Ein neues antifungales Antibioticum,Streptomyces sp. Ac₂(435) wurde mit breitem Spektrum isoliert. Die aktive Substanz ist ein amorphes, nicht-kristallines weisses Pulver, das in Wasser mässig löslich ist. Die Substanz ist lichtempfindlich und bei 100°C inaktiv. Vergleichsproben mit bekannten Substanzen ergaben eine Tetraenverbindung.