FoxO mediates APP-induced AICD-dependent cell death

<正>Supported financially by the National Natural Science Foundation of China,Prof.Xue Lei's group at Shanghai Key Laboratory of Signaling and Disease Research,School of Life Science and Technology,Tongji University published a research article in Cell Death and Disease(2014,5:e1233),entitled"FoxO mediates APP-induced AICD-dependent cell death".     

The oncogene c-Junimpedes somatic cell reprogramming

<正>With the support by the National Natural Science Foundation of China,the Ministry of Science and Technology of China,and the Chinese Academy of Sciences,the laboratory led by Prof.Pei DuanQing(裴端卿)and Prof.Chen JieKai(陈捷凯)at Guangzhou Institutes of Biomedicine and Health,Chinese Acade-     

纳米技术在干细胞研究中的应用

基于纳米技术的干细胞研究是指运用纳米技术开展干细胞的相关研究, 包括基于纳米技术的干细胞微环境培养、干细胞转染、干细胞分离、干细胞组织工程以及干细胞检测、跟踪和成像等, 是结合干细胞和纳米技术这两个前沿科技领域迅速发展并逐渐形成的一个新兴研究方向. 本文评述了最近几年纳米技术应用于干细胞研究的进展, 主要体现在基于纳米颗粒的干细胞分离纯化、纳米颗粒用于干细胞的标记与成像, 纳米颗粒作为基因或其他药物分子的载体转染干细胞以及三维纳米结构控制干细胞增殖分化等方面. 同时, 就纳米材料与干细胞的生物效应研究现状作了阐述, 并进一步展望了基于纳米技术干细胞研究的发展前景与关键问题.     

Extensive supporting cell proliferation and mitotic hair cell generation by in vivo genetic reprogramming in the neonatal mouse cochlea

正Subject Code:H13With the support by the National Natural Science Foundation of China,the research team led by Prof.Li Huawei(李华伟)at the Otorhinolaryngology Department,Affiliated Eye and ENT hospital,State Key Laboratory of Medical Neurobiology of Fudan University,achieved the mitotic hair cell generation through agenetic reprogramming procedure,which was published in the Journal of Neuroscience(2016,36(33):8734—8745).     

New DNA probe for studying cell membrane interactions

正Subject Code:B05 With the support by the National Natural Science Foundation of China and the US National Institutes of Health,a team led by Dr.Tan Weihong(谭蔚泓)at Hunan University and the University of Florida reported a new DNA probe for studying cell membrane interactions,which was recently published in     

Molecular basis of fever boosting immune cell trafficking

<正>With the support by the National Natural Science Foundation of China,the National Basic Research Program of China,the Chinese Academy of Sciences,and the China Postdoctoral Science Foundation,the research team led by Prof.Chen JianFeng(陈剑峰)at Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Sciences,uncovers a mechanism to explain how fever promotes T lymphocyte trafficking and enhances immune surveillance during infection through a thermal sensory heat shock protein90 (Hsp90)-α4 integrin pathway,which was published in Immunity (2019,50:137—151).     

Tracing hematopoietice stem cell formation at single-cell resolution

<正>With the support by the National Natural Science Foundation of China,the research teams led by Prof.Liu Bing(刘兵),Tang Fuchou(汤富酬)and Yuan Weiping(袁卫平)respectively at the Academy of Military MedicalSciences,Peking University,and Chinese Academy of Medical Sciences uncovered the mystery of hematopoietic stem cell formation by single-cell functional and RNA-Seq analysis,which was published     

Chiralitycontrols mesenchymal stem cell lineage diversification through mechanoresponses

<正>With the support by the National Natural Science Foundation of China,the research team directed by Prof.Deng XuLiang(邓旭亮)and Prof.Wei Yan(卫彦)at Peking University Stomatology Hospital and     

A color-tunable,weavable fiber-shaped polymer light-emittingelectrochemical cell

<正>With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Peng Huisheng's laboratory at the Department of Macromolecular Science,Fudan University,reported a color-tunable,weavable fiber-shaped polymer light-emitting electrochemical cell,which was published in Nature Photonics(2015,9(4):233—238).     

TFH细胞调控因子研究进展

滤泡辅助性T细胞(T follicular helper cell, T_FH)是CD4⁺ T细胞家族的新成员, T_FH细胞不但在辅助生发中心(germinal center, GC)形成和维持的过程中发挥重要作用, 也是辅助GC中B细胞分化为浆细胞的关键因素. 近年来的研究已证实, Bcl-6是调控T_FH细胞分化的重要分子, T_FH细胞通过分泌细胞因子IL-21而作用于滤泡B细胞, 以促其分化. 本文就调节T_FH细胞分化的主要因子及其作用机制作一综述.     

掺Gd上转换发光纳米棒的细胞成像应用

利用水热法合成了Gd掺杂的具有上转换发光特性的NaYF₄:Gd/Yb/Er纳米棒, 对材料的形貌、晶体类型和光致发光光谱进行了分析. 采用化学方法在上转换发光纳米棒表面修饰了聚乙二醇分子, 使油溶性的NaYF₄:Gd/Yb/Er纳米棒转化成了水溶性纳米材料, 实现了离体细胞的上转换发光成像.     

The fluorochromic hydrogel for 3D cell culture

正With the support by the National Natural Science Foundation of China,the research team led by Prof.Yang DaYong (仰大勇)at the Frontier Science Center for Synthetic Biology and Key Laboratory of     

Current understanding of the mechanisms of stem cell aging

Remarkable progress has taken place in the research of stem cells during the past 30 years.General perceptions,experimental and clinical evidences pinpoint the fact that functional decline of tissue often coincides with aging-related diseases.Stem cell aging plays a fundamental role in the dysregulation of tissue function,maintenance,and repairing.This review specifically focuses on the current findings and emerging concepts of hematopoietic stem cell aging and its mechanisms.     

Genomic and molecular characterization of esophageal squamous cell carcinoma

Supported by the National Natural Science Foundation of China （Grant No. 81330052） and National High-Tech Rg.D Program of China （Grant Nos. 2012AA02A503 and 2012AAO2A209）, Prof. Wang Mingrong＇s group at the Cancer Institute/Hospital, Chinese Academy of Medical Sciences published their recenl study, entitled ＂Genomic and molecular characterization of esophageal squamous cell carcinoma＂ in Nature Genetics （ 2014, 46（5）. 467 473）.     

Researchers from China constructed the first mammalian cell map

正With the support by the National Natural Science Foundation of China,researchers from Zhejiang University School of Medicine created the mouse cell atlas using a new high throughput single cell analysis platform.The related article"Mapping the Mouse Cell Atlas by Microwell-seq"was published in Cell on February 22nd,2018.Since the discovery of the cell as the fundamental unit of life,investigators have tried hard to     

Researchers from China constructed the first human cell map

正With the support by the National Natural Science Foundation of China,the research team led by Guo GuoJi(郭国骥)at Zhejiang University School of Medicine created a human cell landscape using single-cell sequencing technology.The related article"Construction of a Human Cell Landscape at Single-cell Level"was published in Nature on March 26,2020.     

New approach for segmentation of overlapping blood cell images

提出一种基于血细胞近圆形特征的粘连血细胞分割方法.用形态学腐蚀得到距离图和图像的边缘,并利用灰度重建得到细胞的中心区域和圆心,在此基础上基于细胞圆形特征对细胞的边缘进行搜索,得到粘连细胞的分离点,从而求得分离线,完成对粘连血细胞的精确分割.实验表明,该分离方法是有效可行的.     

有机无机杂化钙钛矿太阳能电池简介

由于近年来人们对于能源和环境问题的重视,有机无机杂化钙钛矿受到了越来越多的关注。钙钛矿作为一种兼具了有机组分和无机组分优点的材料,在光伏发电、发光、铁电、光探测器等领域有着很好的应用前景。钙钛矿作为光伏材料具有晶形规整、吸收光范围广、吸光量大、光致发光寿命长、荧光强度高等多种优越的性能,可有效降低太阳能电池产业的生产成本,减少电池制备过程的能耗并缓解环境污染,提高电池的光电转化效率;而将其用作光致发光材料可得到光强更强、光子寿命更长的荧光。本文主要介绍了近年来被用于制作太阳能电池的多种钙钛矿材料与器件,并对钙钛矿太阳能电池的发展趋势进行了探讨。     

Reducing hypothalamic stem cell senescence protects against aging-associated physiological decline

正With the support by the National Natural Science Foundation of China,the research team led by Prof.Luo XiangHang(罗湘杭)at the Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital of Central South University,reported that a long non-coding RNA,Hnscr,is sufficient to protect against the senescence of htNSCs and aging-like phenotypes in mice,which was published in Cell