Morphine suppression of ethanol withdrawal in mice

Summary The acute administration of morphine, alcohol or dopamine results in a pronounced suppression of the convulsions produced by alcohol in mice. The suppressive action of morphine on alcohol withdrawal in the mouse apparently is not a product of morphine intoxication, but rather to some other specific interaction between alcohol and morphine in the central nervous system. The conclusion suggest that dopamine may play a significant role as a modulator in convulsions produced during alcohol withdrawal.Dr.Kenneth Blum is Associate Professor in Pharmacology at The University of Texas Health Science Center at San Antonio and a Career Teacher in Drug Abuse and Alcoholism under a grant number 1-TO1-DA00290-01 from the National Institute on Drug Abuse.Acknowledgments. Our thanks are due toB. Wiggins, R. Marin andS. Elston for their excellent technical assistance. Research funded in part by Air Force Grant No. AFOSR-71-2075.     

Morphine selectively facilitates the inspiratory-inhibitory vagal reflex in adult rabbits

In rabbits naive to opiates or pretreated with morphine a selective morphine-induced facilitation of the Breuer-Hering inflation reflex is described.     

Post-heparin esterase in man

Zusammenfassung Es werden einige Eigenschaften der menschlichen Serumesterase nach Heparinapplikation beschrieben.     

Experimental study in rats to reduce carbon monoxide in the blood induced by cigarette smoke, by inhaling oxygen at atmospheric pressure]

When animals are exposed to cigarette smoke, the concentration of carbon monoxide in blood is rapidly increased, so that intensive inhalation tests cannot be carried out. A simple apparatus is described to expose Rats alternatively to cigarette smoke and to oxygen in order to reduce the concentration of carbon monoxide in the blood. This method makes it possible to increase the daily administration of smoke considerably; nevertheless, under such conditions, lung tumors were not observed.     

Morphine as inhibitor of prostaglandin E1 in the isolated guinea-pig intestine

Zusammenfassung Es wird gezeigt, dass Analgetika vom Morphintypus die am isolierten Meerschweinchen-dünndarm nach Zugabe von Prostaglandin E₁ erfolgenden Kontraktionen ähnlich wie die durch Arachidonsäure (-peroxid) erzeugten Kontraktionen in spezifischer Weise zu antagonisieren vermögen.     

Specific calcitonin-binding proteins in man

Résumé La protéine porteuse spécifique de la CT-H est l'IgM lorsque la teneur en hormone est relativement faible (jusqu'à 250 ng/ml de plasma). Lorsque la concentration augmente, la CT-H se lie aux ₂-macroglobulines, ₂-lipoprotéines et à l'albumine, dont l'affinité pour l'hormone est moindre mais la capacité de liaison importante. Il est logique d'admettre que des anomalies portant sur les protéines porteuses spécifiques modifient la distribution et le métabolisme de la CT, ce qui représenterait un mécanisme pathophysiologique nouveau de dyscalcitonie humaine.     

Early B lymphocytes in man

Summary We have confirmed in man the presence of a subpopulation of B lymphocytes which cannot reexpress their immunological receptors after challenge with antibodies. These early B lymphocytes were studied in peripheral blood, in cord blood and also, with anti-idiotypic sera, in the peripheral blood of a myeloma patient.Acknowledgments. This work was supported by CNR, Progetti finalizzati, Controllo della Crescita Neoplastica. We thank Prof. J. Urbain for helpful suggestions.     

Cannabidiol and cannabinol in man

Résumé Le cannabidiol administré à dose de 100 mg par os et de 30 mg par injection i.v. fut inactif dans les sujets d'étude. Le cannabinol, à dose orale de 400 mg, le fut aussi. Ces constituants du cannabis ne contribuent donc pas à l'effet pharmacologique.     

Periodicity in body temperature in man

Summary Body temperatures and self-assessed mood scales were recorded for 7 weeks or more by male volunteers. Auto-correlations of temperatures from the 21 subjects show evidence of a significant peak at the 20-day-interval. The self-assessed measure of Alertness (from 18 of them) also shows some evidence of rhythmicity, at the 22-day-period.     

The kidney and fibrinolysis in man

Zusammenfassung Während Nierenoperationen vorgenommene Messungen ergaben, dass eine in der Funktion stark eingeschränkte Niere weniger Urokinase in den Urin ausscheidet, ohne dass jedoch die fibrinolytische Aktivität im Venenblut zunimmt. Es wird daraus geschlossen, dass die Nieren keine erheblichen Mengen Plasminogen-aktivierender Stoffe an das Blut abgeben.

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This study was supported in part by a grant from the Polish Academy of Sciences. — The authors are deeply indebted to Dr.A. Szkodny for his valuable help in taking blood samples during surgery.     

Transaminase in seminal plasma of man

Résumé La transaminase glutamo-oxaloacetique (GO-T) a été déterminée dans le liquide spermatique de l'homme après la séparation des spermatozoïdes. On a trouvé des valeurs élevées pour la GO-T dans le sperme normal et une diminution accentuée dans les cas d'oligospermie et surtout d'azoospermie. Les conditions de la prostate et des vésicules séminales semblent être responsables de cet abaissement de l'activité enzymatique puisque le liquide sans spermatozoïdes (azoospermie) présente encore une activité bien marquée.     

Morphine tolerance in a human neuroblastoma line: Changes in choline acetylase and cholinesterase activities

Zusammenfassung Nachweis der Entstehung einer Morphin-Toleranz und-Dependenz sowie von Veränderungen (Steigerung der Cholinesterase, Verminderung der Cholin-o-Acetyltransferase) von Enzymaktivitäten nach länger dauernden Morphingaben bei Neuroblastom-Kulturen.

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Acknowledgements. This work was supported by grant No. U-2270 from the Health Research Council of the City of New York, a Lucy G. Moses Fellowship and an Irma T. Hirschl Career Scientist Award (to G.M.)     

Odorous urine following asparagus ingestion in man

The production of odorous urine after the ingestion of asparagus has been shown to occur in 43% of 800 volunteers investigated. This characteristic is reproducible over a 12-month-period and has been shown to remain with individuals for virtually a lifetime. Family studies suggest that the ability to produce the odorous urine is inherited as an autosomal dominant trait.