über die Wirkung des Kohlenoxyds auf Atmung und Ionenaufnahme von Weizenwurzeln

Summary The effect of carbon monoxide upon oxygen consumption and ion absorption in wheat roots has been studied. In the dark, inhibition of respiration by CO (in sufficiently high concentrations) is nearly as great as the maximum inhibition in cyanide. Similarly, the chloride absorption is strongly inhibited. Inhibition of respiration and ion absorption by CO is light-reversible.     

Über die Wirkung von Elastase auf die Blutgerinnung

Summary Purified elastase prepared by adsorption on synthetic zeolite in proper concentrations causes the coagulation of blood. Elastase was found to have no direct coagulative action on purified fibrinogen. Its coagulating action is due to the fact that it reacts with prothrombin to form thrombin. The reaction between prothrombin and elastase is independent of the presence of either platelets, thromboplastin or Ca-ions.     

Über die Wirkung von Cobalt-II-nitrat auf Kern und Cytoplasma vonAcetabularia mediterranea

Summary The effect of Cobalt-II-nitrate was tested on the marine green algaAcetabularia. Application of Co immediately stopped regeneration as well as synthesis of cytoplasmic proteins. Later on a decrease of the protein contents was observed. Without affecting the size of the nucleus, Co caused a reduction of the nucleolar size and shape within 4 days. By histochemical methods, Co was found to be stored in the nucleus and nucleolus. However, it is not clear whether the Co was already boundin vivo. Size and distribution of the polyphosphate bodies were not changed within 6 days. No storage of Coin vivo could be observed within the polyphosphates.

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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.     

Über die Wirkung von Pyribenzamin und anderen Antihistaminika auf die durch Histaminverabreichung erzeugten Magenulzera

Summary Ulcers of the stomac of guinea-pigs, produced by subcutaneous application of histamine, are reduced to a significant degree in number by peroral application of antihistaminics. The effect is corresponding to the given dosage. Pyribenzamin proved to be the most effective.     

Über die Wirkung von Phenylbutazon auf den Tricarbonsäurezyklus und andere Fermentsysteme

Summary Cholinesterase, hyaluronidase, chondroïtinase and -glucuronidase are not inhibited by phenylbutazone in concentrations up to 10^–3 M.Phenylbutazone accelerates the oxidation of the acids of the Krebs cycle in therapeutic concentrations up to 10 mg%; in higher concentrations it acts as an inhibitor. The inhibition of the -keto acid oxidation begins at lower concentrations of phenylbutazone then for the other intermediates.     

Über die Wirkung von Mischungen eines antigenhaltigen Plasmas mit einem antikörperhaltigen Serum auf die Entwicklung des Fremdkörpergranuloms

Summary It has been shown that local application of a mixture of precipitating antiserum with homologous plasma or serum promotes markedly the growth of granuloma tissue in the rat.     

Über die bakteriostatische Wirkung von Anthocyanen und verwandten Stoffen

Summary Some anthocyanins and flavonols have been found to have no bacteriostatic effect on pathogenic micro-organisms.     

Über den Einfluss von Thrombin und Heparin auf die Fibrinolyse

Summary (1) The dissolution of a fibrin clot may be hastened to an end value by increasing the quantity of thrombin used for coagulation.(2) Increased concentrations of heparin strengthen the fibrinolysis where constant thrombin content is present. The lytic effect is more pronounced by the addition of heparin before than after the coagulation.(3) Fibrinolysis is dependent on the excess amount of thrombin used in cases of constant heparin concentration. Heparin acts only in the presence of thrombin or a component of thrombin to disperse fibrin.     

Über die Einwirkung von Chlordioxyd auf Pektinstoffe

Ohne Zusammenfassung     

Über die Reaktion der höheren und tieferen Reizbildungszentren des isolierten Herzens auf Temperatursenkung

Summary In the isolated rabbit heart perfused by the Langendorff method total heart block has been produced by section of the His bundle. The influence of cooling of the perfusion fluid upon higher and lower automatic centers was studied. The sinoauricular pacemaker responded to cooling with a much greater decrease of the heart rate than did the ventricular automatism. The responsiveness of the atrioventricular node to cooling lay between that of the two others.     

Über die Wirkung der chronischen Colchicin-vergiftung auf experimentelle Mykosen

Summary Rats injected intraperitoneally with colchicin, 35–50 per 100 g daily or every second day, were infected experimentally on 10th day with Nocardia asteroides, Nocardia Leishmani or Torula histolytica. Controls received no colchicin. Animals given colchicin showed diffusion of infection with numerous mycotic granulomes, similar to the results obtained with cortison.     

Über die Wirkung blutzuckersenkender Sulfonylharnstoffe auf das isolierte Rattenzwerchfell

Summary The action of blood sugar depressing sulfonylureas on glucose and oxygen uptake, as well as on glycogen content and formation of C¹⁴O₂ from uniformly labelled C¹⁴-glucose was investigated in rat hemidiaphragms incubated in phosphate buffer. The following results were obtained: (1) Tolbutamide and Carbutamide increased the glucose uptake. (2) Tolbutamide decreased the glycogen-content. (3) Oxygen uptake as well as formation of C¹⁴O₂ were increased by Tolbutamide. (4) The action of Tolbutamide and insuline was equal with respect to glucose uptake but different as regarding the glycogen content, oxygen uptake and CO₂-formation.It is concluded that sulfonylureas increase glucose oxidation in the rat hemidiaphragm probably without increasing insulin sensitivity. To our knowledge this mechanism of action has hitherto not been described.     

Wirkung von Δ4-Cholesten-3,6-dion auf die Auslösung und Entwicklung von Tumoren

Résumé Au cours d'expériences faites avec des substances dérivées du cholestérol, les auteurs ont étudié l'effet du ⁴-cholestène-3, 6-dione sur des souris blanches et noires. Dans divers organes, des tumeurs apparurent qui ne se montrèrent pas chez les animaux de contrôle. Au point de vue de leur structure histologique, de leur degré de malignité et de leur tendance métastasique, les tumeurs observées étaient extraordinaires.     

Über den Einfluß von Oxytocin und Vasopressin auf die Ausscheidung von Kalium und Natrium durch die Niere

Summary In decisive experiments on diuresis with rats it is shown that oxytocin and vasopressin have a contrary effect on the excretion of Na and K. Oxytocin increases the excretion of Na, vasopressin decreases the excretion of Na and raises the excretion of K. The effects on Cl-and water-metabolism may be considered only as consequences of the primary effect on Na and K.     

Über Alliin,die genuine Muttersubstanz des Knoblauchöls

Summary The authors have succeeded in isolating alliin in a pure, crystalline form and in defining its properties. Alliin is characteristic for certain kinds of garlic; it contains sulphur and nitrogen and represents the initial substance of garlic oil. Alliin itself has no bactericidal action. Upon decomposition—caused by a specific concomitant enzyme, alliinase—the highly bactericidal substance, allicin, is produced. Further decomposition yields the volatile, sharply-odorous allyl-sulphides.     

Wirkung eines tumorhemmenden Stoffes,des Triäthylenmelamins,auf das Wachstum von Fremdkörpergranulom und Tumor

Summary The action of Triethylenmelamine, an anti-tumour substance, was investigated on tumourgrowth and on development of the foreign body granuloma comparatively.It was found that this substance induces in both cases a similar dosis-dependent inhibition of growth.As the inhibiting action of Triethylenmelamine can even be demonstrated on rapidly growing normal tissues, it is questionable whether the antagonistic action against tumour can be designed as tumour-specific.