川芎嗪在大鼠肠吸收机理及当归提取液对其吸收的影响

研究川芎嗪在大鼠肠吸收动力学,考察不同质量浓度川芎嗪及不同体积比的当归提取液混合物对其吸收速率及相关参数的影响.运用大鼠在体单向肠灌流法测定,重量法校正系统误差,HPLC测定吸收前后药物质量浓度的变化,考察其吸收动力学及当归提取液对其吸收的影响.结果表明,不同质量浓度(10,20,40 mg/L)川芎嗪的大鼠肠吸收速率常数分别为(0.006 39±0.052 3),(0.006 51±0.019 1),(0.006 03±0.073 7)min-1,无显著性差异;川芎嗪标准溶液与当归提取液按体积比为1∶2,1∶1,2∶1混匀时,川芎嗪的吸收速率常数分别为(0.012 32±0.106 4),(0.010 24±0.086 1),(0.006 195±0.079 9)min-1,结果显示,川芎嗪的吸收速率常数与当归提取液占混合液的体积分数呈现正相关.川芎嗪在大鼠肠道为被动吸收过程,当归提取液对其有一定的促吸收作用,且随着当归提取液量的增加而增大.     

β-环糊精在绿原酸分离中的应用研究

用β－ 环糊精作载体，使与金银花茎叶提取液中的绿原酸共沉淀，以达到药用成份的分离。     

β—环糊精在绿原酸分离中的应用研究 

用β－环糊精作载体，使与金银花戏叶提取液中的绿原酸共沉淀，以达到药用成份的分离。     

“当归-川芎”药对中阿魏酸在体肠吸收研究

考察"当归-川芎"药对中阿魏酸肠吸收动力学及影响因素.采用在体循环灌流法,应用HPLC测定肠吸收循环液中阿魏酸的质量浓度,UV法测定肠吸收循环液中即时酚红质量浓度.研究比较"当归-川芎"药对及单味药当归、川芎中阿魏酸的吸收情况,药对中阿魏酸的吸收在质量浓度、pH值及胃肠道方面均表现出较大的优越性.药对配伍影响其成分阿魏酸的体内吸收动力学行为.     

离子交换树脂纯化杜仲叶绿原酸条件的筛选

目的：探讨采用离子交换树脂对杜仲叶绿原酸提取液进行纯化的工艺条件。方法：本实验利用静态吸附法,分别采用AmberliteFPA98CL、Amberlite FPA958CL、强碱性苯乙烯离子交换树脂（AMBERLITE FPA90Cl）三类树脂对杜仲叶绿原酸粗提液进行纯化。结果：通过比较绿原酸的提取率和树脂吸附率筛选出最适合纯化绿原酸的工艺条件即采用罗门哈斯公司Amberlite FPA98CL树脂在pH4条件下,与其它两种树脂相比,对绿原酸的收率最高,能够达到鲜叶绿原酸的最大收率为3.04%。结论：采用罗门哈斯公司Amberlite FPA98CL树脂分离杜仲叶绿原酸可到达收率较高、纯度较好的分离效果。     

复方龙瞿提取液的安全性研究

通过分析药物半数致死量(LD50)是检测药物安全性的常规方法, 并运用家兔刺激性试验检测了复方龙瞿提取液能否注射给药. 灌胃给予小白鼠不同剂量的复方龙瞿提取液, 常规饲养一周后统计, 结果: MIC=19600mg/BW, LD100= 37800.56mg/BW;镜检小白鼠的内脏器官, 无明显的损坏现象. 给予家兔浓度为30%、60%、90%的复方龙瞿提取液2ml分别于12、24、48h后处死并观察肌肉的反应情况;结果显示家兔肌肉刺激性试验中肌肉平均反应级数为1级. 结论: 复方龙瞿提取液是低毒性的药物, 并可以通过肌肉注射的方式给药.     

盐酸齐拉西酮大鼠在体肠吸收动力学

建立灌流液中盐酸齐拉西酮含量的高效液相色谱法(HPLC),研究盐酸齐拉西酮的SD大鼠在体肠吸收动力学。采用大鼠在体单向肠灌流模型,研究盐酸齐拉西酮在不同肠段的吸收特性以及不同药物浓度和胆汁分泌对盐酸齐拉西酮吸收的影响。结果表明:盐酸齐拉西酮在大鼠全肠段均有吸收,其中十二指肠吸收大于结肠,吸收速率常数(K)分别为(4.69±0.33)和(2.61±0.37)h-1。盐酸齐拉西酮在不结扎胆管的十二指肠吸收速率大于结扎胆管。随着肠灌流液中盐酸齐拉西酮浓度的升高,吸收速率常数呈上升趋势。盐酸齐拉西酮在体的吸收方式为被动扩散。     

右旋糖酐铁注射液对雌雄性新西兰家兔注射部位吸收效果的比较

目的考查右旋糖酐铁注射液对雌、雄家兔铁的吸收度,并对测定结果进行比较和评价。方法选用新西兰家兔右后腿进行股内肌注射,采用自身空白对照法设置对照组,肉眼观察肌肉着色情况,用紫外分光光度法测定铁的吸收度,分别计算出雌雄新西兰家兔未吸收铁的含量;对家兔每日的饮食量进行称量,所有数据采用平均值±标准差(x珋±s),组间比较采用t检验。结果雌性新西兰家兔比雄兔对右旋糖酐铁的铁吸收更好,而且注射部位染色能力及在组织中扩散均小,对雌性家兔日均饮食量无显著影响;雄性家兔在第5天、第6天饮食量与雌性差异有统计学意义。结论不同性别的家兔对右旋糖酐铁注射液的铁的吸收度存在明显的差别,雌性新西兰家兔铁吸收优于雄性新西兰家兔,两者有统计学差异(P0.05),与雌性家兔日均饮食量比较,右旋糖酐铁对雄性家兔饮食的作用差异有统计学意义(P0.05)。提示右旋糖酐铁的疗效与动物性别有关,临床上应加强对铁注射液的合理选择及应用。     

荫风轮总黄酮对心血管系统的作用

荫风轮总黄酮(CPF)对麻醉正常家兔有一过性降压作用。用CPF灌流离体蟾蜍心脏,可降低心脏收缩力、减慢心率。CPF尚能阻止垂体后叶素引起的家兔心电图ST-T的变化,提高注射肾上腺素及去甲肾上腺素小鼠耐缺氧的能力。     

金银花中绿原酸的超滤纯化

采用超滤法纯化金银花提取液中的绿原酸.考察膜的截留相对分子质量、操作压力、原料液浓度以及pH等因素对超滤效果的影响,探讨膜通量的衰减规律,并将优化后的结果与醇沉法比较.结果表明:在考察的3种膜中,控制压力0.07 MPa、pH 3.5时截留相对分子质量50000的膜超滤效果最好.采用浓缩液回流的方式对原始浓度的提取液超滤后,浓缩液再稀释3次,继续稀释超滤,绿原酸的纯度为19.6%,是醇沉法的1.6倍,回收率为98.9%,比醇沉法高12.3%.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that