Beeinflussung der ATPase aminspeichernder Granula von Nebennierenmark und Milznerven durch Thallium

Summary ATPases of the amine storing granules from bovine adrenal medulla and splenic nerves are inhibited by Tl⁺⁺⁺ 3×10^–5 and 5×10^–6 M, respectively. Tl⁺ up to 10^–3 M is ineffective. By T1⁺⁺⁺ in concentrations of 10^–4 M or more, proteins are precipitated, so that the enzyme inhibiton by these concentrations is unspecific. If T1⁺ is oxidized to Tl⁺⁺⁺ in the organism, the inhibition of granular ATPase may be responsible for the alterations of the catecholamine metabolism observed in thallium intoxication.     

Beeinflussung der Borstendifferenzierung und Musterbildung durch Mitomycin beiDrosophila melanogaster

Summary Injection of mitomycin C into late third instar larvae ofDrosophila leads during metamorphosis to the differentiation of bristles without sockets and bracts, and to altered bristle patterns in structures of the integument.     

Die Beeinflussung der Mikrophonpotentiale durch endocochleare Applikation von Jodacetat

Summary The microphonic potentials of the cat were found to be reduced by endocochlear application of iodoacetate. The rate of decrease was markedly influenced by the intensity of the stimulus.     

Die Beeinflussung der Mitose durch Urethan

Summary 2% aqueous solution of urethan causes after 6–10 hours' action on root types ofVicia faba andAllium cepa a shortening of chromosomes, it stops also the metaphase and lowers the rate of mitosis. Probably there is a connection between the lipophile groups, the reduction in surface tension, and the diminution of chromosomes. Dioxan with similar physical properties has the same effect.     

Beeinflussung der Bromsulphalein-Clearance durch Sulfonamide beim Kaninchen

Summary Investigations in the rabbit demonstrate that even low doses of sulfonamides increase BSP clearance to about twice its normal level.     

Beeinflussung der Antennendifferenzierung durch Colchicin bei derDrosophilamutanteAristopedia

Summary A decrease in growth rate of the antennal bud by means of colchicine deflects the differentiation of theAristopedia antenna towards an arista.

---

---

DieDrosophilamutanteAristopedia unterscheidet sich von der Wildform durch die Umwandlung der Fühlergeißel (=Arista) in einen Fuß.     

Beeinflussung der «Adrenalin-Oxydasen» des Blutplasmasin vivo durch biogene Monoamine und Neuropharmaka

Summary In rats adrenaline, noradrenaline, histamine and iproniazid induced in blood plasma a significant increase of the mean of the enzyme activity of adrenaline oxidases (-globulin-factors, different from coeruloplasmin, ferritin and catalase). Reserpine showed initially an increase and later a decrease and ephedrine caused a decrease of the enzymic activity.     

Beeinflussung mikrosomaler Enzyme durch Tetrachlorkohlenstoff mit und ohne Phenobarbitalvorbehandlung

Summary Isolated damage of the drug-metabolizing enzyme system, the binding power of the endoplasmic reticulum for hexobarbital and aniline, and glucose-6-phosphatase, appears 3 h after oral administration of carbon tetrachloride. The damage is evidently dependent on the dose and can become enlarged after phenobarbital pretreatment.

---

---

Die Ergebnisse wurden teilweise auf der 11. Pharmakologischen Frühjahrstagung in Mainz im März 1970 vorgetragen.     

Über die Beeinflussung der Ca-Aufnahme in Lipidextrakte aus Mikrosomen und Mitochondrien des Herzens durch Digitoxin

Summary Lipids were isolated by chloroform-methanol extraction from mitochondrial and microsomal fractions of guinea-pig hearts. In the presence of digitoxin (10^–9-10^–6 g/ml) 15–30% more radioactive Ca was taken up by the lipid extracts than under control conditions, but the total amount of Ca in this phase remained unchanged. Thus, digitoxin produced an increase in the specific activity of the lipid-bound Ca which may be explained by an increased exchangeability of this Ca fraction. This effect of digitoxin might result in an improved availability of the lipid-bound Ca for Ca-dependent functions (e.g. contraction) of the heart muscle cell.     

Beeinflussung der DNS-Synthese durch Sulfit im Wurzelmeristem der Puffbohne (Vicia faba)

Summary Sulfite inhibits the DNA-synthesis in the root meristem fromVicia faba L.     

2-Br-α-Ergokryptin: Beeinflussung von Fertilität und Laktation bei der Ratte

Summary The inhibitory actions of -ergocryptin on fertility and lactation in the rat are altered differentially in the 2-bromo derivative of this ergot alcaloid. It is therefore unlikely that the fertility inhibiting and the lactation inhibiting effects of 2-bromo--ergocryptin are governed by a single mechanism of action.     

Antagonismus zwischen Heparin und 5-Hydroxytryptamin (Serotonin)in vitro

Summary In the isolated rat colon and uterus, heparin caused inhibition or elimination of contractions occurring after the administration of 5-hydroxytryptamine. In contrast to this, neither Tyrode's solution, nor glycogen, nor dextran produced any change in the response of these organs to 5-hydroxytryptamine.     

Aufhebung der Knospenruhe von Reben durch Rindite

Summary Rindite and ethylene chlorhydrin have a promotive effect on breaking dormant buds of grape cuttings and of one year old pot-grown plants. The optimal dosis was approximately 6 mg Rindite per bud.     

Beeinflussung des Generationszyklus und seiner Teilphasen bei Ehrlich-Aszitestumoren verschiedener Ploidie durch Cyclophosphamid

Summary The effect of the alkylizing agent cyclophosphamide (100 mg/kg i.p.) on the cell cycle of the diploid (EAT dipl.) and hypertetraploid (ELT) Ehrlich ascites tumor growing in the peritoneal cavity of male NMRI-mice has been studied by autoradiography with H³- and C¹⁴-thymidine (double labelling technique and method of labelled mitoses). The results suggest that the proliferation kinetics of tumor cells after administration of cyclophosphamide is dependent essentially on the type of tumor strain tested.     

Stimulierung der Atmung durch Bradykinin und Kallidin

Summary In guinea pigs and rabbits small doses of bradykinin and kallidin (1–8 µg/kg i.v.), which have no bronchoconstrictor effect, stimulate respiration causing tachy- and hyperpnea. Bilateral vagotomy as well as salicylates (4–40 mg/kg i.v.) abolish these respiratory responses.     

Beeinflussung tierexperimenteller Leukopenien durch Vitamin A

Summary In high doses synthetic vitamin A proved to have a leucopoetic effect on the experimental leucopenia of rats. In the treatment of the succinylsulfathiazol leucopenia vitamin A does not equal the effect of folic acid, in the treatment of the milk leucopenia however it is superior to the latter.     

Verlust der anti-inflammatorischen Wirkung von Phenylbutazon (Butazolidin-Geigy) und Cortison durch Ablation vonThyreidea undParathyreoidea

Summary The anti-inflammatory action of Cortisone and Phenylbutazone (Butazolidin-Geigy, TM.), as demonstrated e.g. on the formalin oedema of rats, is abolished after extirpation of the thyroid and parathyroid glands. This result seems to indicate a participation of the incretory organs mentioned on the anti-inflammatory mechanism of these products.     

Erzeugung von Rigor der Rattenxtremitäten durch Hemmung der Glyzin-Synthese

Summary Inhibition of glycine synthesis by aminopterine, an antagonist of pteroilglutaminic acid, causes rigidity of hind limbs in rats. This rigidity can be abolished by the injection of glycine.     

Untersuchungen zur Klärung der Funktion des Reissnerschen Fadens. In-vitro-Bindung von Noradrenalin,Adrenalin und Serotonin

Summary The glycoprotein of Reissner's fibre is able to bind norepinephrine, epinephrine and serotonin. Bound amines can be demonstrated at the RF, even after washing with artificial cerebrospinal fluid for some, hours. It is discussed whether it is a function of the RF to remove substances, for instance biogenic amines, from the cerebrospinal fluid.