Noradrenalin-Freisetzung aus dem Hypothalamus in vitro

Summary Rat hypothalami were isolated and incubated at 37 °C in Ringer solution. Both calcium and acetylcholine enhance the release of noradrenaline. The effect of acetylcholine is dependent on the presence of calcium ions.

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Durchgeführt mit. Unterstützung der Deutschen Forschungsgemeinschaft.     

Unterschiede zwischen Tyramin und Dimethylphenylpiperazin in der Ca++-Abhängigkeit und im zeitlichen Verlauf der Noradrenalin-Freisetzung am isolierten Kaninchenherzen

Summary On the perfused rabbit heart a constant infusion of tyramine released noradrenaline continuously and independently of the external Ca⁺⁺ concentration. In contrast, noradrenaline release by DMPP was only transient and required the presence of Ca⁺⁺.

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Mit Unterstützung der Deutschen Forschungsgemeinschaft.     

Bestimmung von Glykolyse-Metaboliten in isolierten Zellkernen

Summary Isolated rat liver nuclei have been analyzed for the intranuclear concentration of 8 glycolytic metabolites, and in addition for the 3 adenine nucleotides, and for malate. All these substrates are to be found in nuclei in a range of concentration comparable to that in the whole tissue. The consequences of these findings with respect to the definite establishment of glycolysis in isolated nuclei, as well as for the intranuclear formation of energy-rich phosphate bonds, are discussed.

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Meinem Lehrer, Prof. Dr. Dr.K. Lang, in aller Verehrung und Dankbarkeit zum 60. Geburtstag gewidmet.     

Das Elektroretinogramm der isolierten Katzennetzhaut bei Zuwachsreizen

Summary The electroretinogram of the isolated cat retina in response to incremental stimuli was studied with varying intensities of background and/or stimulus. The results are explained in terms of known components.     

Mechanismus der Reaktion von Invertseifen mit isolierten Zellen

Summary Reaction equilibria were established between an invert soap on the one side and carbon, lecithin, erythrocytes and yeast cells on the other side. From the parallelism of the invert soap-lecithin and the invert soap-erythrocytes curves a specific reaction of the invert soap with the lipoids of the erythrocytes may be concluded, whereas the invert soap-yeast cells curves yield a pure adsorption isotherm corresponding to the invert soap-carbon curve.     

Der Nachweis des Barbiturateffektes an der isolierten Warmblüternetzhaut

Summary Barbiturates cause an increase of the ERG amplitude in the isolated perfused retina of the rabbit as well as in the eye of the intact animal. Therefore, this effect cannot be transmitted by centrifugal fibres in the optic nerve.     

Der Einfluss von Barbituraten auf das ERG der isolierten Froschnetzhaut

Summary The influence of barbiturates on the electroretinogram was studied in the isolated perfused retina of the frog; a-, b-, and d-waves were altered differently. The effect (increase or decrease in amplitude) depended on the concentration as well as on the duration of application.     

Das Elektrovenogramm (Evg) der isolierten Flughautvene (Chiroptera)

Summary The electrovenogram of the isolated vein of the wing membrane (Chiroptera) exhibits two main irregularities in its diphasic action current—a fast initial wave before the beginning of the systole and a very protracted after-wave. Following this the rise and fall of potential run parallel with the contraction and dilatation of the vessels.     

Kompetitiver Antagonismus zwischen g-Strophanthin und Corticosteron an isolierten Streifen von Rattenaorten

Summary Corticosterone was shown to have an inhibitory effect on the contraction caused by a cardiac glycoside (g-Strophanthin = Ouabain) in isolated strips of rat aorta. It could be demonstrated that over a tenfold concentration range of Ouabain, the kinetics of this antagonism are in accord with the assumption of a competitive inhibition.

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Diese Arbeit wurde erm?glicht durch ein Stipendium der ? Stiftung der CIBA für naturwissenschaftliche, medizinische und technische Forschung ?.     

Actin aus Kalbsherzmuskel

Summary Sedimentation coefficient, intrinsic viscosity, amino acid composition and myosin binding capacity of actin from calf's heart were determined. The results are in fair agreement with values published for actin from other sources. No influence of strophantin-g or strophantin-k on the velocity of polymerization and the viscosity and thixotropy of f-actin could be detected.     

Sexchromatinbestimmung aus der Haarwurzel

Summary A method is described by which sex chromatin can be easily and routinely determined in the cell nuclei of the root sheath of a single pulled human hair.     

Synthese von Solanidin aus Demissidin

Summary The steroidal alkaloid solanidine (solanid-5-ene-3-ol, II) which occurs in the potato plantSolanum tuberosum L. has been synthesized from demissidine (5-solanidane-3-ol, I), an alkaloid from the Mexican wild potatoSolanum demissum Lindl. The synthesis involves the following steps: 5-solanidane-3-one, 2,4-dibromo-5-solanidane-3-one, solanid-4-ene-3-one, 3-acetoxy-solanida-3,5-diene, and solanidine (II).

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Solanum-Alkaloide. XVII. Mitteilung. — XVI. Mitteilung:K. Schreiber undG. Adam, Exper.17, 490 (1961).     

Darstellung doppelbrechender Lipoidtropfen aus dem Serum

Summary (1) Doubly refracting lipoid droplets can be demonstrated in normal and pathological sera by means of alcohol ether extraction. This is not possible with ether extraction alone.(2) These lipoid droplets can be demonstrated only, or almost only, when they are precipitated out of alcohol or ether alcohol     

Blutagglutinierende und toxische Eiweissfraktionen aus Bohnen

Summary Soluble proteins from black beans (Phaseolus vulgaris) have been separated into 4 fractions, one soluble in 1% NaCl-solution and 3 water soluble. The latter were separated by ammonium sulfate fractionation. The haemagglution of these fractions is compared with their toxicity in mice when applied by intraperitoneal injection. The LD₅₀ of the most active fraction was about 50 mg/kg. When used in mice of different strains, the toxicity was not the same while the blood cells were agglutinated by the same final concentration. Crotonoil-induced papilloma-bearing mice were slightly more resistant than normal animals.     

Hemmung der Phosphodiesterase aus Rattenherzen durch Intensain

Summary Intensain causes in vitro a significant and apparently competitive inhibition of phosphodiesterase, which transforms the 3,5-AMP to 5-AMP. These results explain some intensain effects, especially the period of latency to reach the maximum effect, the inotropic action and its reaction under the influence of-blocking and-stimulating agents^10–13.

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3-(-Diäthylamino-äthyl)-4-methyl-7-carbäthoxy-methoxy-2-oxo-(1,2-chromen), Carbochromen.     

Kristallisation des Präalbumins aus Humanserum

Summary The thyroxine binding prealbumin was crystallized by ammonium sulphate, sodium sulphate, magnesium sulphate, sodium phosphate and potassium phosphate. The form of the orthorhombic crystals was dependent on pH.

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Für Diskussionen über die Form der Kristalle sind wir Herrn Prof. Dr. E.Hellner und Herrn Dr. R.Allmann vom Mineralogischen Institut der Universität Marburg zu Dank verpflichtet.     

Eine im Alkalischen wirksame Monophosphoesterase aus Hefe

Summary The authors describe a monophosphoesterase isolated from yeast which acts strongly on sodium phenolphthaleinphosphate, phenolphosphate, and-glycerophosphate in an alkaline medium (p _H 8,5–9,1). The enzyme does not need magnesium ions for its activity.     

Das Zirkon-Alter granitischer Gesteine aus dem Gotthardmassiv

Ohne Zusammenfassung