Understanding as explanatory knowledge: The case of Bjorken scaling

In this paper, we develop and refine the idea that understanding is a species of explanatory knowledge. Specifically, we defend the idea that S understands why p if and only if S knows that p, and, for some q, S’s true belief that q correctly explains p is produced/maintained by reliable explanatory evaluation. We then show how this model explains the reception of James Bjorken’s explanation of scaling by the broader physics community in the late 1960s and early 1970s. The historical episode is interesting because Bjorken’s explanation initially did not provide understanding to other physicists, but was subsequently deemed intelligible when Feynman provided a physical interpretation that led to experimental tests that vindicated Bjorken’s model. Finally, we argue that other philosophical models of scientific understanding are best construed as limiting cases of our more general model.     

Neuropeptide Y: the universal soldier

The peptidic neurotransmitter neuropeptide Y (NPY) has received great attention because it has been implicated in the regulation of several organ systems. In particular, NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. Furthermore, NPY exerts vasoconstrictive action on the vasculature and potentiates the actions of many other vasoconstrictors. In addition, it was demonstrated to have trophic properties and could therefore contribute to cardiovascular remodeling. These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure. Received 17 July 2002; received after revision 7 November 2002; accepted 29 November 2002 RID="*" ID="*"Corresponding author.     

The moon-test in Newton's Principia: Accuracy of inverse-square law of universal gravitation

Communicated by J. D. North     

Bronchial asymmetry and Fibonacci scaling

The irregular branching pattern of the bronchial tree in multiple mammalian species is consistent with a process of morphogenetic self-similarity described by Fibonacci scaling.     

Bronchial asymmetry and Fibonacci scaling

Summary The irregular branching pattern of the bronchial tree in multiple mammalian species is consistent with a process of morphogenetic self-similarity described by Fibonacci scaling.     

The wavelet scaling approach to forecasting: Verification on a large set of Noisy data

In the paper, we undertake a detailed empirical verification of wavelet scaling as a forecasting method through its application to a large set of noisy data. The method consists of two steps. In the first, the data are smoothed with the help of wavelet estimators of stochastic signals based on the idea of scaling, and, in the second, an AR(I)MA model is built on the estimated signal. This procedure is compared with some alternative approaches encompassing exponential smoothing, moving average, AR(I)MA and regularized AR models. Special attention is given to the ways of treating boundary regions in the wavelet signal estimation and to the use of biased, weakly biased and unbiased estimators of the wavelet variance. According to a collection of popular forecast accuracy measures, when applied to noisy time series with a high level of noise, wavelet scaling is able to outperform the other forecasting procedures, although this conclusion applies mainly to longer time series and not uniformly across all the examined accuracy measures.     

The role of periostin in lung fibrosis and airway remodeling

Periostin is a protein that plays a key role in development and repair within the biological matrix of the lung. As a matricellular protein that does not contribute to extracellular matrix structure, periostin interacts with other extracellular matrix proteins to regulate the composition of the matrix in the lung and other organs. In this review, we discuss the studies exploring the role of periostin to date in chronic respiratory diseases, namely asthma and idiopathic pulmonary fibrosis. Asthma is a major health problem globally affecting millions of people worldwide with significant associated morbidity and mortality. Periostin is highly expressed in the lungs of asthmatic patients, contributes to mucus secretion, airway fibrosis and remodeling and is recognized as a biomarker of Th2 high inflammation. Idiopathic pulmonary fibrosis is a fatal interstitial lung disease characterized by progressive aberrant fibrosis of the lung matrix and respiratory failure. It predominantly affects adults over 50 years of age and its incidence is increasing worldwide. Periostin is also highly expressed in the lungs of idiopathic pulmonary fibrosis patients. Serum levels of periostin may predict clinical progression in this disease and periostin promotes myofibroblast differentiation and type 1 collagen production to contribute to aberrant lung fibrosis. Studies to date suggest that periostin is a key player in several pathogenic mechanisms within the lung and may provide us with a useful biomarker of clinical progression in both asthma and idiopathic pulmonary fibrosis.     

The brachymorphic mutation of mice and altered developmental patterns of limb bud 3':5' cyclic adenosine monophosphate

Concentrations of cyclic AMP (cAMP) were determined in paired fore and hind limbs from day 12-16 of development in murine fetuses homozygous for the brachymorphic (bm) mutation and normal controls. A developmental rise in cAMP occurred 1 day earlier in bm/bm than in +/+ hind limbs and cAMP was higher in day-13 bm/bm than in +/+ fore limbs. Since cAMP is well documented to stimulate chondrogenic differentiation, premature cartilage determination secondary to altered levels of cAMP could play a role in bm/bm short-limbed dwarfism.     

The effect of scale changes on repetitive patterns: Influence of 6-aminonicotinamide on feather germ number

There are many examples of patterned developing systems which are size invariant: if the total size of the system is reduced, then the pattern responds by changing its scale in such a way that the number of pattern elements remains constant. This phenomenon is one of the bases which underaly the formulation of the concept of positional information, one of the great unifying ideas in developmental biology. However, there are less common examples of patterns which are size dependent. In these, alterations of overall size lead to a reduction in pattern elements. Such size-dependent patterns are therefore of theoretical interest. Here we describe how the number of feather germs along the wing bud of the developing chick embryo responds to shortening of the limb, and consider the implications of these observations.     

超温水体蒸发系数通用公式的研究与应用

在环境参数可控风洞中对影响蒸发的风速、水气温差、水温、相对湿度等物理量进行系统试验。试验结果表明蒸发系数取决于风速的强迫对流和水气温差的自由对流。分析试验数据得到了水面蒸发系数的建议公式和相应的水面散热系数公式以及附加蒸发系数公式。用参数变幅很大的天然水体和受纳废热水体的实测资料和研究成果检验了建议公式的通用性。建议公式已为DL／T5084-98《电力工程水文技术规程》及GB／T50102-2003《工业循环水冷却设计规范》推荐应用于计算水面蒸发、水面散热及附加蒸发。     

The variability of patterns of sexual dimorphism in the hominoid skull

Summary Univariate and multivariate statistical analyses are applied to a number of cranial dimensions and angles from living hominoids in order to investigate the patterns of sexual dimorphism in these groups. Clear differences in patterns of cranial sexual dimorphisms are demonstrated not only between genera but also within a single species (Homo). These differences overlay the common finding of a sexual size difference in all groups. The results imply that caution is required in using the sexual dimorphisms of living hominoids as models for those anticipated in fossils.     

The variability of patterns of sexual dimorphism in the hominoid skull

Univariate and multivariate statistical analyses are applied to a number of cranial dimensions and angles from living hominoids in order to investigate the patterns of sexual dimorphism in these groups. Clear differences in patterns of cranial sexual dimorphisms are demonstrated not only between genera but also within a single species (Homo). These differences overlay the common finding of a sexual size difference in all groups. The results imply that caution is required in using the sexual dimorphisms of living hominoids as models for those anticipated in fossils.     

The development of gene therapy for diseases of the lung

The development of a successful gene therapy has many stages, including preclinical testing in animal models and proof of principle clinical studies. A variety of diseases affect the lung, which are candidates for gene therapy; this review will mainly focus on the diseases that have attracted the most attention and have therefore yielded the most progress, namely lung cancer and the monogenic disorder cystic fibrosis. Knowledge gained from clinical studies could eventually be applied to more complex lung conditions such as acute respiratory distress syndrome and asthma. In addition, increased gene transfer efficiencies could be obtained by appropriate selection of the gene transfer vector and mode of delivery.Received 8 August 2003; received after revision 10 September 2003; accepted 17 September 2003     

The chromosome banding patterns of the aardvarkOrycteropus afer (Tubulidentata,Orycteropidae)

Summary C- and G-banding patterns ofOrycteropus afer are described on the basis of fibroblast cultures obtained from a female individual.This work was supported in part by a research grant DEB 76-10580 from the National Science Foundation.     

The dynamics of serum lipoprotein patterns in vitamin C-saturated and vitamin C-deficient guinea-pigs after carbon tetrachloride poisoning

Zusammenfassung Aus einer Experimentalarbeit, bei welcher die Konzentration der papierelektrophoretisch gewonnenen Lipoproteinfraktionen des Serums Vitamin-C-gesättigter und avitaminöser Meerschweinchen verglichen wurde, geht hervor, dass die Frühstadien der C-Avitaminose den Spiegel der ₁-Lipoproteine bedeutend erhöhen und den der ₂-Lipoproteine herabsetzen. Dies und die Ergebnisse der durch Tetrachlorkohlenstoff hervorgerufenen Leberschädigung weisen auf die Tatsache hin, dass die Frühstadien der C-Avitaminose den Mechanismus, der den normalen Spiegel der Serumlipoproteine reguliert, beeinflussen, obwohl gleichzeitig die Regenerierungsprozesse der durch Tetrachlorkohlenstoff geschädigten Leber der Beeinflussung entzogen bleiben.