sST2与急性冠脉综合征冠脉病变程度相关性分析

目的探讨急性冠脉综合征(ACS)中血清可溶性生长刺激表达基因2蛋白(Soluble growth stimulator gene 2protein,s ST2)、超敏C反应蛋白(High sensitive C reaction protein,Hs CRP)、中性粒细胞和淋巴细胞计数比值(Neutrophil to lymphocyte ratio,NLR)与冠脉病变程度的相关性.方法将173例冠心病患者分为急性冠脉综合征(ACS)组(110例,实验组)和稳定型心绞痛(SA)组(64例,对照组),ACS患者中包括急性心肌梗死(AMI)组54例和不稳定性心绞痛(UA)组56例,均行s ST2、Hs CRP、血常规水平检测,比较各组间血清s ST2、Hs CRP及NLR,分析其与冠脉病变严重程度(冠脉病变支数和Gensini积分)的相关性.结果 ACS组s ST2、Hs CRP及NLR均高于SA组(P0.05); AMI组s ST2、Hs CRP及NLR均高UA组(P0.05); ACS组s ST2与Hs CRP、NLR呈正相关(P0.05); s ST2、Hs CRP及NLR与ACS患者在不同冠脉病变支数之间差异无统计学意义(P 0.05); ACS组s ST2、Hs CRP及NLR与Gensini积分之间均呈正相关(P0.05);回归分析显示:s ST2、NLR是ACS冠脉病变严重程度的预测因子.结论 s ST2、Hs CRP、NLR的水平随着ACS病情进展而逐渐升高,考虑与冠脉粥样斑块的不稳定性有关; s ST2和NLR是ACS冠脉病变程度的预测因子,但s ST2的参考价值更大.     

动态分析NLR预测急性胰腺炎严重程度及器官衰竭的临床价值

目的探讨中性粒细胞与淋巴细胞比值(NLR)在预测急性胰腺炎(AP)严重程度及器官衰竭中的临床价值.方法回顾性分析141例AP患者住院当天(NLR-0)和入院后24 h(NLR-1)、48 h(NLR-2)、72 h(NLR-3) NLR值;根据AP患者严重程度分为MAP组(96例)及SAP组(45例),根据是否发生器官衰竭分为器官衰竭(-)组(117例)及器官衰竭(+)组(24例),采用ROC曲线比较NLR预测能力.结果 MAP组NLR-0,NLR-1,NLR-2,NLR-3的NLR中位数均低于SAP组(P0. 05);器官衰竭(-)组NLR-0,NLR-1,NLR-2,NLR-3的NLR中位数均低于器官衰竭(+)组(P0. 05); NLR在NLR-1时预测AP患者严重程度(AUC:0. 714,最佳截断值5. 18)及器官衰竭发生率(AUC:0. 739,最佳截断值4. 81)的准确度最高.结论 NLR入院24 h预测AP严重程度及器官衰竭发生的准确性最高.     

呼出气一氧化氮检测对咳嗽变异性哮喘控制水平的评估价值

探讨呼出气一氧化氮（FeNO）检测对咳嗽变异性哮喘控制水平的评估价值。选择2019年1月—2020年6月收治的咳嗽变异性哮喘急性期患者65例为研究组，另选咳嗽变异性哮喘缓解期患者65例为参照组。比较研究组治疗前后的呼出气一氧化氮、EOS%、FEV1与FVC、FEV1/FVC和参照组的差异，分析研究组患者的呼出气一氧化氮与EOS%、FEV1与FVC、FEV1/FVC各指标存在的相关性，对比治疗前后2组8-iso-PG水平。研究组治疗前的呼出气一氧化氮高于参照组，EOS%、FEV1与FVC、FEV1/FVC低于参照组，P<0.05。研究组治疗后的呼出气一氧化氮、EOS%、FEV1与FVC、FEV1/FVC与参照组比较，P>0.05。呼出气一氧化氮和EOS%比较，r=0.617、P=0.026<0.05，相关性表现为正相关。研究组治疗前后的8-iso-PG水平显著高于参照组，P<0.05。咳嗽变异性哮喘患者的呼出气一氧化氮水平和EOS%具有正相关的特点，经个性化治疗后患者的呼出气一氧化氮水平显著降低，肺功能指标明显改善，而患者中8-iso-PG水平也可反映其气道氧化应...     

降钙素原与C-反应蛋白在恶性肿瘤发热患者中的鉴别意义

本文探讨血清降钙素原与C-反应蛋白在恶性肿瘤发热患者中的鉴别意义.将200例肿瘤合并发热患者经检测白细胞计数、中性粒细胞百分率、PCT、CRP阳性率情况分为肿瘤感染组及肿瘤发热组,并进行比较分析.结果发现肿瘤感染组与肿瘤发热组比较:白细胞计数升高(χ2=44.505),中性粒细胞百分比升高(χ2=45.298),CRP升高(χ2=55.354),PCT升高(χ2=127.1),差异有统计学意义(P0.01).从而表明PCT和CRP检测有助于鉴别肿瘤患者的发热原因,为抗感染及肿瘤的治疗提供指导及依据.     

激素对慢性阻塞性肺疾病患者IL-8和LTB_4及肺功能的影响

目的:观察在治疗慢性阻塞性肺疾病急性加重期(AECOPD)时全身应用糖皮质激素对痰上清液和血清中白介素8(IL-8)和白三烯B4(LTB4)及肺功能的影响。方法:将33例AECOPD患者随机分为治疗组17例,对照组16例。两组均给予常规治疗,同时治疗组给予静脉和口服甲泼尼龙或泼尼松,观察比较两组治疗前后痰上清液和血清中IL-8和LTB4水平、肺功能及呼吸困难(VAS)改善情况。结果:治疗前,痰上清液和血清中IL-8、LTB4水平均高于治疗后,二者间有直线相关关系;且与第1秒钟用力呼气容积(FEV1)、第1秒钟用力呼气容积占预计值百分比(FEV1%)、第1秒钟用力呼气容积与用力肺活量的比值(FEV1/FVC)间有负相关(P0.05)。治疗后,痰上清液IL-8、LTB4的变化与痰中性粒细胞百分比(Neu%)、VAS的变化有显著相关性(P0.05)。与对照组相比,治疗组呼吸困难症状缓解快,痰中性粒细胞减少、痰上清液和血清中IL-8、LTB4的下降水平、FEV1、FEV1%和FEV1/FVC改善幅度均较大。结论:AECOPD患者IL-8和LTB4水平增高,这些变化与临床症状和肺功能相关。使用激素可减轻炎症反应、改善肺功能和缓解患者临床症状。     

中性粒细胞与淋巴细胞比值对急性主动脉夹层患者 预后的预测价值

目的:探讨中性粒细胞与淋巴细胞比值(NLR)对急性主动脉夹层(AAD)患者短期和长期死亡风险的预测价值.方法:回顾性分析141例AAD患者的临床资料,分组:①依据随访2周结果将患者分为死亡组(n=41)及存活组(n=100);②依据NLR 4分位数将患者分为NLR4.33(Q1组,n=35),4.33≤NLR7.26(Q2组,n=35),7.26≤NLR11.78(Q3组,n=36),NLR≥11.78(Q4组,n=35).结果:短期内死亡组NLR显著高于存活组,死亡组NLR=9.67(6.81,13.07)、存活组NLR=6.18(3.63,11.10),死亡组的NLR水平比存活组的更高(P0.05).KM生存曲线显示,Q4组的短期和长期死亡风险均明显高于其他3组.多因素Cox比例风险回归模型显示,与Q1组比较, Q4组增加短期死亡风险28倍,HR 28.403,95%CI 3.392(237.865),增加长期死亡风险3倍,HR 3.396,95%CI 1.596(7.228),有统计学差异(P0.05).结论:入院NLR≥11.78可明显增加AAD患者的短期和长期死亡风险,NLR愈高,预后愈差.     

布地奈德联合孟鲁司特对哮喘患者肺功能及免疫功能的影响分析

目的探讨布地奈德联合孟鲁司特对哮喘患者进行干预后患者肺功能及免疫功能的变化.方法将80例哮喘患者分为观察组和对照组,对照组采用布地奈德雾化吸入,观察组在对照组基础上服用孟鲁司特片;在治疗前及治疗结束2周后观察患者肺功能、血清IL-4及INF-γ、外周血Ig E和嗜酸性粒细胞(EOS)水平.结果治疗后两组患者FEV1,FEV1/FVC及PEF均显著升高(P0.05),且观察组升高水平显著高于对照组(P0.05);治疗后患者血清中IL-4水平显著降低(P0.05),INF-γ显著升高(P0.05),且观察组患者IL-4降低水平及INF-γ升高水平均显著高于对照组(P0.05);治疗后两组患者外周血Ig E及EOS水平均显著降低(P0.05),且观察组患者降低水平显著高于对照组(P0.05).结论应用布地奈德联合孟鲁司特对哮喘患者进行治疗,可有效改善患者肺功能及免疫功能,提高临床疗效.     

舒利迭与孟鲁司特钠联合治疗对支气管哮喘患者肺功能的影响

观察舒利迭与孟鲁司特钠联合用药对支气管哮喘患者肺功能的影响。选取甘肃省定西市中医院收治的支气管哮喘患者92例作为研究对象,随机分为对照组和研究组,各46例。两组患者入院后均进行抗感染、平喘、止咳等常规基础治疗,对照组在常规治疗基础上给予舒利迭进行治疗,研究组在对照组基础上加用孟鲁司特钠进行治疗,两组均连续治疗3个月。观察两组患者治疗前后肺功能变化情况以及临床治疗效果。两组患者治疗前FEV1、FEV1/FVC水平差异无统计学意义(P0.05),治疗后较治疗前均有所上升(P0.05),且治疗后研究组FEV1、FEV1/FVC水平均明显高于对照组(P0.05);研究组临床治疗总有效率95.65%明显高于对照组80.43%(P0.05)。舒利迭与孟鲁司特钠联合治疗支气管哮喘疗效显著,且能明显改善患者肺功能,值得临床应用推广。     

PM2.5暴露对哮喘大鼠气道形态及FOXP3基因DNA启动子区甲基化影响的实验研究

目的探讨PM2. 5暴露对哮喘大鼠气道形态及FOXP3基因DNA启动子区甲基化的影响。方法选择50只SD大鼠,随机选择10只作为空白对照组,40只采用卵清蛋白激发、致敏构建哮喘模型,并根据PM2. 5干预剂量的不同,进一步分为单纯哮喘组、低剂量组、中剂量组、高剂量组,比较不同剂量PM2. 5对哮喘大鼠的病程进展影响。结果 1)与对照组及单纯哮喘组相比,所有PM2. 5干预组大鼠的体质量均明显较低(P 0. 05)。(2)与对照组相比,哮喘组肺泡灌洗液内细胞总数升高最显著,低、中剂量干预组也明显升高,但高剂量干预组无明显变化(P> 0. 05)。与对照组及哮喘组比较,随着PM2. 5干预剂量的升高,大鼠BALF内的嗜酸性粒细胞、中性粒细胞、淋巴细胞计数也呈逐渐上升趋势,巨噬细胞呈逐渐下降趋势,差异均具有统计学意义(P <0. 05)。(3)对照组、哮喘组、低剂量组、中剂量组、高中剂量组的FOXP3基因DNA启动子区的甲基化水平分别为(7. 24±0. 91)、(5. 04±3. 08)、(1. 87±1. 46)、(1. 57±0. 64)、(2. 04±1. 14),FOXP3 mRNA相对表达量分别为(1. 02±0. 18)、(0. 81±0. 19)、(0. 62±0. 15)、(0. 53±0. 14)、(0. 32±0. 04),随着PM2. 5干预剂量的提高,大鼠的FOXP3基因DNA启动子区的甲基化水平及FOXP3 mRNA相对表达量均逐渐降低。结论 PM 2. 5对哮喘大鼠的损伤有一定的剂量依赖性,这可能与调低FOXP3基因DNA启动子区甲基化水平及FOXP3 mRNA相对表达量有关。     

射干麻黄汤联合沙丁胺醇治疗支气管哮喘的作用观察

观察射干麻黄汤与沙丁胺醇联合治疗方案应用于临床支气管哮喘治疗过程中所发挥的作用。选择秦安县人民医院收治的64例支气管哮喘患者,随机分为两组各32例,对照组给予丁胺醇进行治疗,研究组给予射干麻黄汤与沙丁胺醇联合治疗方案,治疗4周后评价2组疗效,并检测2组患者肺功能相关指标。2组总有效率比较,研究组明显高于对照组(P0.05);治疗后2组用力肺活量(FVC)、第一秒用力呼气量(FEV1)明显升高(P0.05),呼吸昼夜呼气流量峰值(PEF)变异率明显下降(P0.05),且研究组肺功能各项观察指标变化情况均明显优于对照组(P0.05)。射干麻黄汤与沙丁胺醇联合治疗方案应用于临床支气管哮喘治疗过程中,在增进疗效与改善肺功能两方面均获得可靠效果。     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with