Hydroxyapatites enriched in silicon – Bioceramic materials for biomedical and pharmaceutical applications

Hydroxyapatite (Ca10(PO4)6(OH)2, abbreviated as HA) plays a crucial role in implantology, dentistry and bone surgery. Due to its considerable similarity to the inorganic fraction of the mineralized tissues (bones, enamel and dentin), it is used as component in many bone substitutes, coatings of metallic implants and dental materials. Biomaterial engineering often takes advantage of HA capacity for partial ion substitution because the incorporation of different ions in the HA structure leads to materials with improved biological or physicochemical properties. The objective of the work is to provide an overview of current knowledge about apatite materials substituted with silicon ions. Although the exact mechanism of action of silicon in the bone formation process has not been fully elucidated, research has shown beneficial effects of this element on bone matrix mineralization as well as on collagen type I synthesis and stabilization. The paper gives an account of the functions of silicon in bone tissue and outlines the present state of research on synthetic HA containing silicate ions (Si-HA). Finally, methods of HA production as well as potential and actual applications of HA materials modified with silicon ions are discussed.     

个性的张扬与升华——台版昆剧《李香君》中香君形象分析

一代名妓李香君历来为人们所称道,且不同的时代有不同的诠释和理解。曾永义先生根据清代传奇《桃花扇》改编的昆剧《李香君》更加凸显了李香君忠贞不渝的爱情、不畏权势的英勇气概及对独立人格的捍卫。在当下多元价值观念并存、信仰紊乱的社会环境中,曾先生重塑的香君形象对引导人们树立正确的人生观和价值观具有一定的启迪作用。     

物理化学实验在药学教育中的改革与探索

结合药学专业的特点，从优化实验内容、规范实验教学过程、更新实验教学手段入手，进行物理化学实验教学改革。     

杭州市医药产业比较研究

⒈与省内其他市地比较⑴杭州市医药工业总产值增速高于上年,全省排名回归首位据省医药行业办提供的数据显示,2004年,杭州医药工业总产值赶超台州,回到了2002年排名全省第1的位置,高于排名第3第4的绍兴和金华近20个亿,但仅高于排名第2的台州3个亿,差距不大,领先全省的地位还是不稳固。杭州占浙江省医药工业总产值的比重为23.67%,与上两年相比,比重基本保持不变。2004年增长率高于上年,达到22.85%,比总产值排名第2的台州高出10个百分点,增速高于台州。但增长率在11个地市中,位居第3,比上年上升1位,略高于全省的平均水平21.15%。表1近4年杭州与…     

微生物多糖的生物合成及代谢工程研究进展

综述了微生物多糖的生物合成途径、基因簇结构与功能和代谢工程的研究进展。真菌多糖的合成途径主要包括:前体核苷酸糖(单糖的活化形式)的合成、合成的起始反应、重复单元的延伸、翻转和聚合、多糖的输出。多糖合成过程中涉及大量的基因,大多数基因存在多糖合成基因簇中,随着基因测序技术的发展,大量的多糖合成基因簇被发现和研究。研究表明:通过调控涉及糖核苷酸合成途径的酶水平可提高胞外多糖的产量,而增加多糖合成基因簇基因在微生物中的表达,可产生更高的多糖合成代谢流。     

强制电化学还原技术处理制药废水的研究

制药废水已成为严重的污染源之一。合成药物废水中有机物生化性极差,废水COD达几万以上,且废水含有对微生物有抑制作用的有机物,使生物处理效力降低,增加了生物处理的难度。本文拟采用强制电化学还原技术来提高制药废水水的生化性、降低废水的色度,从而使后续的生化系统得以顺利进行。     

核桃仁的成分与药理研究进展

简述了近年来核桃仁的化学成分、加工与开发及药理作用的研究进展。核桃仁营养成分丰富,含有蛋白质、维生素、碳水化合物及微量元素,药理研究证明,核桃仁具有清除自由基、抗衰老、健脑益智、美容、补肾壮阳等功能。为进一步研究、开发和利用我国丰富的核桃仁资源提供了思路和方法。     

热分析法在药物研究中应用的新进展

综述了热分析方法在药物研究中应用的一些新进展．它主要包括热机械方法和微区热分析法．热机械法是在程序控温下测量物质的机械性能的一种热分析方法,讨论了它在药用材料、药物的机械性能和药物控制释放等研究中的一些应用．微区热分析法是一种将扫描探针显微镜成像技术和热分析技术结合起来的新兴的热分析方法,讨论了它在药用高分子材料、多组分分析、多晶现象、药物剂型和药物控制释放等研究中的应用．     

Human metabolic phenotype diversity and its association with diet and blood pressure

Metabolic phenotypes are the products of interactions among a variety of factors-dietary, other lifestyle/environmental, gut microbial and genetic. We use a large-scale exploratory analytical approach to investigate metabolic phenotype variation across and within four human populations, based on 1H NMR spectroscopy. Metabolites discriminating across populations are then linked to data for individuals on blood pressure, a major risk factor for coronary heart disease and stroke (leading causes of mortality worldwide). We analyse spectra from two 24-hour urine specimens for each of 4,630 participants from the INTERMAP epidemiological study, involving 17 population samples aged 40-59 in China, Japan, UK and USA. We show that urinary metabolite excretion patterns for East Asian and western population samples, with contrasting diets, diet-related major risk factors, and coronary heart disease/stroke rates, are significantly differentiated (P < 10(-16)), as are Chinese/Japanese metabolic phenotypes, and subgroups with differences in dietary vegetable/animal protein and blood pressure. Among discriminatory metabolites, we quantify four and show association (P < 0.05 to P < 0.0001) of mean 24-hour urinary formate excretion with blood pressure in multiple regression analyses for individuals. Mean 24-hour urinary excretion of alanine (direct) and hippurate (inverse), reflecting diet and gut microbial activities, are also associated with blood pressure of individuals. Metabolic phenotyping applied to high-quality epidemiological data offers the potential to develop an area of aetiopathogenetic knowledge involving discovery of novel biomarkers related to cardiovascular disease risk.     

砷在水体和土壤中迁移转化规律的共性与个性

砷是一种有毒元素,对人体有富,通过呼吸道、消化道和皮肤接触进入体内,会积蓄在人体各个器官部位,从而引发慢性中毒,潜伏期和长达几年甚至几十年.所以,我们到对人经常接触到的水体和土壤中的砷元素进行迁移转化的分析,以便于对砷污染的监测和治理.     

论服装表演的个体特性与社会价值

服装表演是一门新兴的实用艺术，本文以服装表演为研究对象，找出其所具有的个体特性与社会价值．通过研究发现，其个体特性主要体现在功利性、传播性和审美性等3个方面；社会价值主要体现在经济价值、信息价值与欣赏价值等3个方面．对服装表演个体特性与社会价值的探讨有助于服装表演的发展，有助于进一步发挥服装表演的功能．     

学术本位的阐释与学理个性的追求--评刘克宽的新著《阐释与重构》

《阐释与重构》是刘克宽先生对当代十七年文学近十年思考的结晶，此书在选题立意上表现出了作者可贵的学术勇气，充分体现了作者独特的学术本位和学理个性追求。