Der Einfluss von Halothan und Chloroform auf die Feinstruktur und Proteinsynthese der Rattenleber

Summary Examinations by electron microscopic and autoradiographic techniques of whether chloroform and halothane alter protein synthesis in rat liver, demonstrate, that chloroform causes an early destruction of the granular endoplasmatic reticulum accompanied by a marked decrease of the protein synthesis in the centre of the acini. After anaesthesia with halothane, the granular endoplasmatic reticulum and the protein synthesis proved to remain unaffected.     

Der Einfluss von Calcium auf die Brenzcatechinaminfreisetzung

Summary (1) Experiments on isolated perfused suprarenals of cattle have shown that the acetylcholine-induced release of catechol amines, but not that of phenylethylamine, is dependent on calcium, since a perfusion with calcium-free Tyrode's solution abolishes the action of acetylcholine and not that of phenylethylamine. (2) Inincubation experiments with isolated chromaffin granules, calcium produces a dose-dependent, significant release of catechol amines even in physiological concentrations (2.5 mM). (3) Acetylcholine does not release catechol amines from isolated granules, either in the presence or in the absence of calcium.

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Forschungs-Stipendiat der A. von Humboldt-Stiftung.

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Ausgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft.     

Der Einfluss von adrenergen Rezeptoren-Blockern auf die Wirksamkeit von Strahlenschutzsubstanzen

Summary The effect of -adrenergic receptor-inhibitors was examined in relation to the effectiveness of radioprotective agents. The results, when mice were irradiated, show that the receptor-inhibitors significantly reduced the effect of the applied protectors.     

Der Einfluss von Acetylcholin auf die42Kalium-Abgabe postnataler,denervierter und reinnervierter Skeletmuskulatur

Summary The loss of⁴²K from the isolated rat diaphragm into the bathing solution is increased by acetylcholine, (a) 3 to 4 days after birth, (b) 7 to 14 days after sectioning of the phrenic nerve. The⁴²K loss is not altered by acetylcholine in the diaphragm of adult rats and after the denervated diaphragm has become reinnervated.     

Der Einfluss von Chlorpromazin auf die oxydative Phosphorylierung von Tumormitochondrien

Summary High concentrations of chlorpromazine cause a considerable decrease of the oxidative phosphorylation of tumor mitochondria and rat liver mitochondria. Regarding preliminary experimental and clinical investigations, we assume that malignant tumors can be sensitised to cytotoxic substances and ionising radiations impairing their energy metabolism by uncoupling the oxidative phosphorylation.     

Der Einfluss von 4-Benzylhydroxy-3,5-dijodbenzoesäure auf die oxydative Phosphorylierung von Leber- und Tumormitochondrien

Summary The effects of 4-benzylhydroxy-3,5-diiodobenzoic acid on isolated mitochondria ofWalker carcinosarcoma 256 and liver tissue of the same animals were compared. It was shown that, by the same concentrations of the uncoupling halo-phenol, the oxidative phosphorylation of tumor mitochondria was impaired in a higher degree than that of liver mitochondria.     

Der Einfluss des Urin-pH auf die Aktivität von Urinenzymen

Summary The relationship between the pH of urine and the measured activity of ULDH, UAP and UAA was investigated in vivo and in vitro. The activity of ULDH and UAP is only half as much, or less, in acid urine (pH 4.8–5.1) as it is in alkaline urine (pH 7.0–8.1). The UAA activity, however, does not change in the pH range measured. The isoenzymes ULDH 2–4, present in alkaline urine of normal adults, does not appear in acid urine.     

Der Einfluss von 2-Deoxy-D-glucose auf die Substratoxydation in Ascites-Tumorzellen

Summary The effect of the glycolytic inhibitor 2-deoxy-D-glucose on the oxidation of¹⁴C-labelled substrates of the tricarboxylic acid cycle was investigated in ascites carcinoma cells of the mouse. In the presence of high concentrations of glucose, deoxyglucose stimulates the oxidation of pyruvate C-2 and C-3 to CO₂, but not the oxidation of succinate C-1,4 to CO₂. While deoxyglucose causes, in the absence of glucose, an inhibition of the oxidation of exogenous palmitate C-1 to CO₂, it causes, in the presence of glucose, a stimulation of the palmitate oxidation. There is a possible correlation between the effect of deoxyglucose on the intracellular ATP metabolism and the effect of deoxyglucose on the palmitate oxidation.     

Isolierung anthocyanhaltiger und anthocyanfreier Gewebestämme vonDaucus carota: Einfluss von Auxinen auf die Anthocyanbildung

Summary The isolation of anthocyanin-producing and non-producing cell lines of tissue cultures ofDaucus carota is described. Those clones which are able to synthesize anthocyanins do this in dark only if there is an auxin like 2,4-D, IAA or NAA present. In light no supplementary auxin is necessary for anthocyanin production. It is assumed that there might be relations between auxin and light-induced anthocyanin biosynthesis.     

Über den Einfluss von Natriumsulfit,Natriumtellurit und Natriumselenit auf die Retention von Zink,Kadmium und Quecksilber im Organismus

Summary The influence of sodium sulfite, sodium tellurite and sodium selenite on the retention of zinc, cadmium and mercury in mice was studied. The retention of mercury was increased by sodium selenite and by sodium tellurite. The retention of cadmium was increased only by sodium selenite. Sodium sulfite did not influence the retention of metals studied. The retention of zinc was not influenced by any compounds used.     

Poterium spinosum und sein Einfluss auf den Blutzuckergehalt von Kaninchen

Summary The decocts prepared from the root and stem of the plant, when administred orally to rabbits, cause a fall in blood sugar level which is highly significant after the dose of 5 g/kg. The log dose/effect curve forms a straight line which confirms the accuracy of the effects observed. Preparations from the fruit were without any effect.     

Einfluss von Psychopharmaka auf die nichtveresterten Fettsäuren im Blutplasma

Summary Several neuroleptics, thymoleptics, tranquilizers, and psychoenergizers were found to elevate plasma-free fatty acid levels in the rat. Chlorpromazine and related substances probably affect both mobilization and utilization of fatty acids.     

Zur Wirkung von Narkotin auf den Hustenreflex und auf die Bronchialmuskulatur

Summary In experiments on cats cough reflexes were elicited by mechanical stimuli applied to the mucosa of the tracheobronchial tree. Narcotine was found to diminish or to depress the cough reflex in doses of 0.1–1.0 mg/kg and was thus about as effective as codeine. On the bronchial muscles narcotine produced no effect or a bronchodilatation whereas codeine produced a bronchoconstrictor effect. As an isochinoline derivative narcotine should not be liable to cause addiction.     

Der Einfluss von Tetracyclin auf die Vermehrung des Kartoffel-Blattrollvirus im VektorMyzus persicae

Summary Tetracycline hydrochloride treatment decreased the transmission rate of potato leafroll virus (PLRV) byMyzus persicae. It also prevented the PLRV-induced swellings of the A/F nuclei of the salivary gland. Apparently there is a connection between these two phenomena. The A/F cells may be a site of virus multiplication.     

Einfluss der Passagegeschwindigkeit auf die Resorption von Glucose im Dünndarm der Ratte

Summary Loops of rat's small intestine have been perfused with 5% glucose solution at different flow rates. The absorption of glucose has been investigated. The results showed that, with increasing flow rates, absorption rate of glucose is also increased. Therefore contact time seems to be no limiting factor in intestinal absorption.

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Mit Unterstützung des Österr. Fonds zur Förderung der wissenschaftlichen Forschung, Projekt Nr. 650.     

Einfluss von Dichlorisoproterenol (DCI) auf die Infusionstoxizität einiger Herzglykoside

Summary In experiments of infusion made on guineapigs, Dichlorisoproterenol was injected after the appearance of the first symptoms of toxicity in the ECG. It reduced the toxicity of convallatoxol, g-strophanthin and lanatosid C, but it was not quite effective against digoxin and digitoxin.

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Über einen Teil der Befunde wurde auf dem 2. Internationalen Pharmakologenkongress in Prag berichtet (Förster undSziegoleit).