Bycatch: interactional expertise, dolphins and the US tuna fishery

The burgeoning field of studies in expertise and experience (SEE) is a useful theoretical approach to complex problems. In light of SEE, examination of the controversial and well known case study of dolphin bycatch in the US tuna fishery, reveals that effective problem-solving was hindered by institutional tensions in respect of decision-making authority and difficulties with the integration of different expertises. Comparing the profiles of four individuals, who played distinct roles in the problem-solving process, I show that (1) to address a complex problem, a suite of contributory expertises—rarely found in one individual—may be required; (2) formal credentials are not a reliable indicator of who possesses these necessary expertises; (3) interactional expertise and interactive ability are useful tools in combining the contributory expertises of others to yield a desirable collective outcome; and (4) the concepts of contributory expertise and no expertise are useful tools for understanding the actual contribution of various parties to the problem-solving process.     

The evolution of a trading zone: a case study of the turtle excluder device

This paper explores the evolution of a trading zone by organizing the case study of turtle excluder devices within the model proposed by Collins et al. (2007). The case study offers evidence that trading zones do evolve and that the concepts of enforced and fractionated trading zones hold practical utility for describing and defining the complexities of actual exchanges. In this case a trading zone evolved from enforced to fractionated and ultimately diverged into two trading zones. For each step of the evolution I describe the forces that drove these transitions. Finally, I present an adapted trading zone model that is conceptually a better fit for the turtle excluder device case study.     

The explanatory role of abstraction processes in models: The case of aggregations

Though it is held that some models in science have explanatory value, there is no conclusive agreement on what provides them with this value. One common view is that models have explanatory value vis-à-vis some target systems because they are developed using an abstraction process (i.e., a process which involves omitting features). Though I think this is correct, I believe it is not the whole picture. In this paper, I argue that, in addition to the well-known process of abstraction understood as an omission of features or information, there is also a family of abstraction processes that involve aggregation of features or information and that these processes play an important role in endowing the models they are used to build with explanatory value. After offering a taxonomy of abstraction processes involving aggregation, I show by considering in detail several models drawn from different sciences that the abstraction processes involving aggregation that are used to build these models are responsible (at least partially) for their having explanatory value.     

Nuclear science and technology in the Malaysian context: Three phases of technoscientific knowledge transfer (ETTLG)

This essay considers the development of the nuclear science programme in Malaysia from a transnational perspective by examining the interactions between state agents and other external nuclear-knowledge/technology related actors and agents. Going beyond the model of knowledge diffusion that brings together concerns articulated in Harris’s (2011) geographies of long distance knowledge and Reinhardt's (2011) role of the expert in knowledge transfer, the proposed three-phase model of knowledge transfer theorises the pathways undertaken by a late-blooming participant of modern science and technology as the latter moves from epistemic dependency to increasing independence despite the hurdles encountered, and the underdevelopment of many areas of its technoscientific economy. The model considers tensions stemming from the pressures of expediency for meeting national developmental goals on the one side, and the call to support the objectives of basic science on the other. The three phases of the model are epistemic transition, epistemic transplantation and localisation, and epistemic generation (ETTLG). As additional support for the proposed model, three arguments are proffered as deeper explanations of the epistemic goal by using Malaysia as a case study: knowledge transfer for political legitimization, knowledge transfer for countering agnotology, and knowledge transfer for social engineering and science diplomacy.     

The role of conjugative transposons in spreading antibiotic resistance between bacteria that inhabit the gastrointestinal tract

There is huge potential for genetic exchange to occur within the dense, diverse anaerobic microbial population inhabiting the gastrointestinal tract (GIT) of humans and animals. However, the incidence of conjugative transposons (CTns) and the antibiotic resistance genes they carry has not been well studied among this population. Since any incoming bacteria, including pathogens, can access this reservoir of genes, this oversight would appear to be an important one. Recent evidence has shown that anaerobic bacteria native to the rumen or hindgut harbour both novel antibiotic resistance genes and novel conjugative transposons. These CTns, and previously characterized CTns, can be transferred to a wide range of commensal bacteria under laboratory and in vivo conditions. The main evidence that gene transfer occurs widely in vivo between GIT bacteria, and between GIT bacteria and pathogenic bacteria, is that identical resistance genes are present in diverse bacterial species from different hosts.     

The role of phosphoenolpyruvate in insulin secretion: the effect of L-phenylalanine

Summary Incubation of rat islets with phenylalanine increased the tissue content of phosophoenolpyruvate, both in the presence and in the absence of glucose. At the same time, L-phenylalanine neither stimulated nor inhibited insulin release. It is unlikely that insulin secretion is tightly coupled to the availability of phosphoenolpyruvate in rat islets.     

The innate immunity of the central nervous system in chronic pain: The role of Toll-like receptors

Toll-like receptors (TLRs) are a family of pattern recognition receptors that mediate innate immune responses to stimuli from pathogens or endogenous signals. Under various pathological conditions, the central nervous system (CNS) mounts a well-organized innate immune response, in which glial cells, in particular microglia, are activated. Further, the innate immune system has emerged as a promising target for therapeutic control of development and persistence of chronic pain. Especially, microglial cells respond to peripheral and central infection, injury, and other stressor signals arriving at the CNS and initiate a CNS immune activation that might contribute to chronic pain facilitation. In the orchestration of this limited immune reaction, TLRs on microglia appear to be most relevant in triggering and tailoring microglial activation, which might be a driving force of chronic pain. New therapeutic approaches targeting the CNS innate immune system may achieve the essential pharmacological control of chronic pain. Received 21 November 2006; received after revision 8 January 2007; accepted 7 February 2007     

International interdependence of business cycles in the manufacturing industry: The use of leading indicators for forecasting and analysis

This article introduces new leading indicators for fifteen industrialized countries which enable the business cycle in manufacturing to be forecast fairly reliably between 4 and 6 months ahead. These indicators are based on an improved variant of the NBER method, yielding a composite leading indicator characterized by less erratic movements and clear turning points. The indicators are used to explore the international interdependence of business cycles and to examine the degree to which this interdependence is affected by growing economic integration, as in the EC. For each of the countries studied, the various foreign economies affecting the local business climate are identified. Since the business cycles of some countries clearly lead those of others, this international interdependence can be used to further improve the predictive power of the leading indicators in the lagging countries.     

Age-related lipid peroxidation in the digestive gland of mussels: The role of the antioxidant defence systems

Summary The main cellular defence systems against free radical-mediated oxidative stress are significantly reduced in the dige⁺ive gland of aged (>10 years old) compared to younger (2–4 years old) mussels (Mytilus edulis L.). Moreover, the concentration of lipid peroxidation products (malondialdehyde) is increased in the same age group with respect to younger animals. The obtained data indicate that an impairment of the antioxidant defence systems would render the older animals more susceptible to peroxidative stress, thus supporting the general significance of the free radical theory of aging.     

Scientific patronage in the age of Darwin: The curious case of William Boyd Dawkins

This essay examines the curious relationship between Charles Darwin and the palaeontologist William Boyd Dawkins (1837–1929). Dawkins was a beneficiary of Darwin's patronage and styled himself as a Darwinian to Darwin and the public, yet viciously attacked Darwin and his theory in anonymous reviews. This has confused historians who have misunderstood the exact nature of Dawkins's attitude towards evolution and his relationship to Darwin. The present study explains both the reasons for Dawkins's contradictory statements and his relationship with Darwin. I introduce Batesian mimicry as a conceptual framework to make sense of Dawkins's actions, suggesting that Dawkins mimicked a Darwinian persona in order to secure advancement in the world of Victorian science. Dawkins's pro-Darwinian stance, therefore, was a façade, an act of mimicry. I argue that Dawkins exploited Darwin for his patronage – which took the form of advice, support from Darwin's well-placed friends, and monetary assistance – while safely expressing his dissent from Darwinian orthodoxy in the form of anonymous reviews. This is, therefore, a case study in how scientific authority and power could be gained and maintained in Victorian science by professing allegiance to Darwin and Darwinism.