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1.
In spinal cats following tetanic stimulation of the cutaneous nerve bilateral dorsal root potentials in the lumbar spinal cord are depressed. Because of differences between ipsi- and contralateral potentials, this depression can usually be evoked only on one side of the cord. 相似文献
2.
Summary The anthelmintic agent piperazine did not antagonize carbachol-induced depolarizations of the frog sartorius muscle but depressed root potentials and acetylcholine release from the frog spinal cord. We suggest that piperazine has a presynaptic site of action at central cholinergic nerve-terminals. 相似文献
3.
The anthelmintic agent piperazine did not antagonize carbachol-induced depolarizations of the frog sartorius muscle but depressed root potentials and acetylcholine release from the frog spinal cord. We suggest that piperazine has a presynaptic site of action at central cholinergic nerve-terminals. 相似文献
4.
Summary Vagal activity decreased significantly during spinal cord warming and increased significantly during spinal cord cooling in anesthetized, immobilized rabbits. The result provide the first direct proof of changes in parasympathetic activity during spinal thermal stimulation. 相似文献
5.
B. H. Hallas 《Cellular and molecular life sciences : CMLS》1982,38(6):699-701
Summary Embryonic cerebral cortical tissue obtained from rat embryos of 15-day gestation was transplanted into the cervical spinal cord of adult rats. The cortical transplants survived, grew, and established connections with the host animal's spinal cord. In other animals, knife lesions were first made in the host's spinal cord, and then embryonic cortical tissue was transplanted into the site of the lesion. The cortical transplants in these animals were observed to become an integral part of the host animal's spinal cord. 相似文献
6.
Pauline De Berdt Pauline Bottemanne John Bianco Mireille Alhouayek Anibal Diogenes Amy Llyod Jose Gerardo-Nava Gary A. Brook Véronique Miron Giulio G. Muccioli Anne des Rieux 《Cellular and molecular life sciences : CMLS》2018,75(15):2843-2856
Secondary damage following spinal cord injury leads to non-reversible lesions and hampering of the reparative process. The local production of pro-inflammatory cytokines such as TNF-α can exacerbate these events. Oligodendrocyte death also occurs, followed by progressive demyelination leading to significant tissue degeneration. Dental stem cells from human apical papilla (SCAP) can be easily obtained at the removal of an adult immature tooth. This offers a minimally invasive approach to re-use this tissue as a source of stem cells, as compared to biopsying neural tissue from a patient with a spinal cord injury. We assessed the potential of SCAP to exert neuroprotective effects by investigating two possible modes of action: modulation of neuro-inflammation and oligodendrocyte progenitor cell (OPC) differentiation. SCAP were co-cultured with LPS-activated microglia, LPS-activated rat spinal cord organotypic sections (SCOS), and LPS-activated co-cultures of SCOS and spinal cord adult OPC. We showed for the first time that SCAP can induce a reduction of TNF-α expression and secretion in inflamed spinal cord tissues and can stimulate OPC differentiation via activin-A secretion. This work underlines the potential therapeutic benefits of SCAP for spinal cord injury repair. 相似文献
7.
Summary Conditioning volleys spreading along 3 segments of the cord produce larger facilitation of bilateral dorsal root potentials in sacral cord than volleys in neighbouring dorsal roots used to evoke the testing depolarization. Contralateral potentials are more facilitated by volleys descending from lumbar than ascending from caudal segments. 相似文献
8.
Conditioning volleys spreading along 3 segments of the cord produce larger facilitation of bilateral dorsal root potentials in sacral cord than volleys in neighbouring dorsal roots used to evoke the testing depolarization. Contralateral potentials are more facilitated by volleys descending from lumbar than ascending from caudal segments. 相似文献
9.
3 dogs could behaviourally modify their own spinal cord temperature (Tspin. cord). In a hot environment, 2 dogs did not cool their spinal cord, 1 dog warmed it. The higher the environmental temperature, the higher the chosen Tspin. cord. These results seem to imply that this latter dog tended, in warm environment, to behaviourally reduce: Ts greater than Tspin. cord (Ts mean skin temperature). Data obtained previously support this explanation. 相似文献
10.
Diego Reginensi Patricia Carulla Sara Nocentini Oscar Seira Abel Torres-Espín Andreu Matamoros-Angles Rosalina Gavín María Teresa Moreno-Flores Francisco Wandosell Josep Samitier Xavier Trepat Xavier Navarro José Antonio del Río 《Cellular and molecular life sciences : CMLS》2015,72(14):2719-2737
Olfactory ensheathing cell (OEC) transplantation emerged some years ago as a promising therapeutic strategy to repair injured spinal cord. However, inhibitory molecules are present for long periods of time in lesioned spinal cord, inhibiting both OEC migration and axonal regrowth. Two families of these molecules, chondroitin sulphate proteoglycans (CSPG) and myelin-derived inhibitors (MAIs), are able to trigger inhibitory responses in lesioned axons. Mounting evidence suggests that OEC migration is inhibited by myelin. Here we demonstrate that OEC migration is largely inhibited by CSPGs and that inhibition can be overcome by the bacterial enzyme Chondroitinase ABC. In parallel, we have generated a stable OEC cell line overexpressing the Nogo receptor (NgR) ectodomain to reduce MAI-associated inhibition in vitro and in vivo. Results indicate that engineered cells migrate longer distances than unmodified OECs over myelin or oligodendrocyte-myelin glycoprotein (OMgp)-coated substrates. In addition, they also show improved migration in lesioned spinal cord. Our results provide new insights toward the improvement of the mechanisms of action and optimization of OEC-based cell therapy for spinal cord lesion. 相似文献
11.
Typical modifications of the unitary discharge of vestibular units have been recorded following the transection of the spinal cord of hemilabyrinthectomized and compensated guinea-pigs. These results support the concept that the spinal cord is essential in the compensation of the symptoms resulting from a lesion of one labyrinth. 相似文献
12.
Summary Typical modifications of the unitary discharge of vestibular units have been recorded following the transection of the spinal cord of hemilabyrinthectomized and compensated guinea-pigs. These results support the concept that the spinal cord is essential in the compensation of the symptoms resulting from a lesion of one labyrinth.Supported by a grant of CNR. 相似文献
13.
Although early after birth the central nervous system is more plastic than in the adult, it already displays limited regenerative capability. This becomes severely impaired at specific stages of embryonic development; however, the precise cellular and molecular basis of this loss is not fully understood. The chick embryo provides an ideal model for direct comparisons of regenerating and non-regenerating spinal cord within the same species because of its accessibility in ovo, the extensive knowledge of chick neural development and the molecular tools now available. Regenerative ability in the chick is lost at around E13, a relatively advanced stage of spinal cord development. This is most likely due to a complex series of events: there is evidence to suggest that developmentally regulated changes in the early response to injury, expression of inhibitory molecules and neurogenesis may contribute to loss of regenerative capacity in the chick spinal cord. 相似文献
14.
Summary DPP IV was localized in the meningeal lamellae of the spinal cord sheaths of the rat by light and electron microscopy. A membrane-bound reaction product of DPP IV was found in the internal, intermediate and external meningeal lamellae which delineated the CSF-filled meningeal spaces. The cells of the marginal glia displayed heterogeneous localization of the reaction product for DPP IV. DPP IV distribution in the spinal cord sheaths suggests its possible participation in the interactions of the meningeal cells with the neuropeptides in cerebrospinal fluid. 相似文献
15.
The Soleus muscle of the rat, 3--6 months old, becomes significantly faster than in the controls, if the spinal cord is cut at birth. Mechanical properties of Extensor Digitorum Longus (EDL) muscle are not altered by spinal cord section. In cordotomized animals Soleus muscle always remains slower than EDL muscle. Denervation, performed 3--6 months after birth, has the same slowing effects in the Soleus and EDL muscles, both in cordotomized and in the control animals. 相似文献
16.
DPP IV was localized in the meningeal lamellae of the spinal cord sheaths of the rat by light and electron microscopy. A membrane-bound reaction product of DPP IV was found in the internal, intermediate and external meningeal lamellae which delineated the CSF-filled meningeal spaces. The cells of the marginal glia displayed heterogeneous localization of the reaction product for DPP IV. DPP IV distribution in the spinal cord sheaths suggests its possible participation in the interactions of the meningeal cells with the neuropeptides in cerebrospinal fluid. 相似文献
17.
M. C. Bosland D. H. G. Versteeg W. de Jong 《Cellular and molecular life sciences : CMLS》1980,36(2):224-224
Summary Local administration of 6-hydroxydopamine in the subarachnoidal space of the spinal cord in rats resulted in a selective long-lasting depletion of spinal noradrenaline, but not of dopamine, and prevented the occurrence of postdecapitation convulsions. 相似文献
18.
Distribution of bilateral dorsal root potentials evoked by volleys in afferents entering lumbar and sacral segments of the spinal cord 总被引:1,自引:0,他引:1
Ipsilateral dorsal root potentials evoked by volleys entering lumbar and sacral segments of the cord are largest at the level of entry of afferent volleys. Contralateral potentials resulting from stimulation of any of these nerves attain maximum amplitude in lower sacral and upper caudal segments. 相似文献
19.
Intraspinal (i.s.) injection of 6-hydroxydopamine or 5,7-dihydroxytryptamine in newborn spontaneously hypertensive rats (SHR) resulted, in the adult animal (30-week-old), in a marked decrease of spinal cord noradrenaline (NA) or 5-hydroxytryptamine (5-HT) levels, respectively. Since both neurotoxin- and vehicle-injected rats developed full hypertension and had similar plasma catecholamine concentrations, it is concluded that in SHR neither spinal cord NA nor 5-HT play a major role in development and maintenance of hypertension. 相似文献
20.
Effects of the spinal cord section and of subsequent denervation on the mechanical properties of fast and slow muscles 总被引:1,自引:0,他引:1
Summary The Soleus muscle of the rat, 3–6 months old, becomes significantly faster than in the controls, if the spinal cord is cut at birth. Mechanical properties of Extensor Digitorum Longus (EDL) muscle are not altered by spinal cord section. In cordotomized animals Soleus muscle always remains slower than EDL muscle. Denervation, performed 3–6 months after birth, has the same slowing effects in the Soleus and EDL muscles, both in cordotomized and in the control animals. 相似文献