From aether impulse to QED: Sommerfeld and the Bremsstrahlen theory

The radiation that is due to the braking of charged particles has been in the focus of theoretical physics since the discovery of X-rays by the end of the 19th century. The impact of cathode rays in the anti-cathode of an X-ray tube that resulted in the production of X-rays led to the view that X-rays are aether impulses spreading from the site of the impact. In 1909, Arnold Sommerfeld calculated from Maxwell׳s equations the angular distribution of electromagnetic radiation due to the braking of electrons. He thereby coined the notion of “Bremsstrahlen.” In 1923, Hendrik A. Kramers provided a quantum theoretical explanation of this process by means of Bohr׳s correspondence principle. With the advent of quantum mechanics the theory of bremsstrahlung became a target of opportunity for theorists like Yoshikatsu Sugiura, Robert Oppenheimer, and–again–Sommerfeld, who presented in 1931 a comprehensive treatise on this subject. Throughout the 1930s, Sommerfeld׳s disciples in Munich and elsewhere extended and improved the bremsstrahlen theory. Hans Bethe and Walter Heitler, in particular, in 1934 presented a theory that was later regarded as “the most important achievement of QED in the 1930s” (Freeman Dyson). From a historical perspective the bremsstrahlen problem may be regarded as a probe for the evolution of theories in response to revolutionary changes in the underlying principles.     

From proportion to balance: the background to symmetry in science

We call attention to the historical fact that the meaning of symmetry in antiquity—as it appears in Vitruvius’s De architectura—is entirely different from the modern concept. This leads us to the question, what is the evidence for the changes in the meaning of the term symmetry, and what were the different meanings attached to it? We show that the meaning of the term in an aesthetic sense gradually shifted in the context of architecture before the image of the balance was attached to the term in the middle of the 18th century and well before the first modern scientific usage by Legendre in 1794.     

Introduction to values and pluralism in the environmental sciences: From inferences to institutions

Philosophers of science continue to elaborate our understanding of the roles that values play in scientific reasoning, practice, and institutions. This special issue focuses on the environmental sciences, a mosaic of fields ranging from restoration ecology to forestry to climatology, unified by its attention to the relationships between humans and their habitats. It is a field that revolves around ameliorating environmental problems, aiming to support the provision of social goods and provide guidance to policymakers about how to regulate individuals and industries. Values abound in such judgments as setting the boundaries of an ecosystem, integrating the human dimensions of social-ecological systems, and collaborating with stakeholders. Since few in the field are likely to insist that these judgments can be made without reference to social values, environmental science can serve as fertile ground for exploring the ethical, social, and political terrain at the frontier of the science and values discourse.     

Relativity of motion: From Occam to Galileo

Early observations of the southern celestial sky were reported in many sixteenth-century books and compilations of voyages of discovery. Here we analyse these accounts in order to find out what was really seen and reported by the first navigators. Our analysis had resulted in new interpretations of the phenomena reported by Amerigo Vespucci and Andreas Corsali. Thus, a reassessment of the discovery of the Coalsack Nebula, the Magellanic Clouds, and the Southern Cross can be made. From a comparative review of the observations of the latter constellation as published between 1500 and 1600, we demonstrate that only questionable records found their way to contemporary compilations of voyages of discovery, and that as a result public knowledge about this constellation at the end of the sixteenth century was entirely unreliable. Another problem we discuss is that although the stars of the Southern Cross were the first to be discovered, and were observed again and again by many navigators, it was not until 1678 that their proper positions were found in stellar atlases and star catalogues accessible to astronomers. We explain how negligence of and subsequently confidence in Ptolemy's astronomy by, respectively, the early navigators and cartographers, were at the root of this amazingly long-lasting gap in the knowledge of the southern celestial sky.     

Myosin I: From yeast to human

Myosin I is a non-filamentous, single-headed, actin-binding motor protein and is present in a wide range of species from yeast to man. The role of these class I myosins have been studied extensively in simple eukaryotes, showing their role in diverse processes such as actin cytoskeleton organization, cell motility, and endocytosis. Recently, studies in metazoans have begun to reveal more specialized functions of myosin I. It will be a major challenge in the future to examine the physiological functions of each class I myosin in different cell types of metazoans.     

From protein sequences to 3D-structures and beyond: the example of the UniProt Knowledgebase

With the dramatic increase in the volume of experimental results in every domain of life sciences, assembling pertinent data and combining information from different fields has become a challenge. Information is dispersed over numerous specialized databases and is presented in many different formats. Rapid access to experiment-based information about well-characterized proteins helps predict the function of uncharacterized proteins identified by large-scale sequencing. In this context, universal knowledgebases play essential roles in providing access to data from complementary types of experiments and serving as hubs with cross-references to many specialized databases. This review outlines how the value of experimental data is optimized by combining high-quality protein sequences with complementary experimental results, including information derived from protein 3D-structures, using as an example the UniProt knowledgebase (UniProtKB) and the tools and links provided on its website (). It also evokes precautions that are necessary for successful predictions and extrapolations.     

From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking

CFTR biogenesis starts with its co-translational insertion into the membrane of endoplasmic reticulum and folding of the cytosolic domains, towards the acquisition of a fully folded compact native structure. Efficiency of this process is assessed by the ER quality control system that allows the exit of folded proteins but targets unfolded/misfolded CFTR to degradation. If allowed to leave the ER, CFTR is modified at the Golgi and reaches the post-Golgi compartments to be delivered to the plasma membrane where it functions as a cAMP- and phosphorylation-regulated chloride/bicarbonate channel. CFTR residence at the membrane is a balance of membrane delivery, endocytosis, and recycling. Several adaptors, motor, and scaffold proteins contribute to the regulation of CFTR stability and are involved in continuously assessing its structure through peripheral quality control systems. Regulation of CFTR biogenesis and traffic (and its dysregulation by mutations, such as the most common F508del) determine its overall activity and thus contribute to the fine modulation of chloride secretion and hydration of epithelial surfaces. This review covers old and recent knowledge on CFTR folding and trafficking from its synthesis to the regulation of its stability at the plasma membrane and highlights how several of these steps can be modulated to promote the rescue of mutant CFTR.     

From Helmholtz to Schlick: The evolution of the sign-theory of perception

Efforts to trace the influence of fin de siècle neo-Kantianism on early 20th Century philosophy of science have led scholars to recognize the powerful influence on Moritz Schlick of Hermann von Helmholtz, the doyen of 19th Century physics and a leader of the zur?ck zu Kant movement. But Michael Friedman thinks that Schlick misunderstood Helmholtz' signature philosophical doctrine, the sign-theory of perception. Indeed, Friedman has argued that Schlick transformed Helmholtz' Kantian view of spatial intuition into an empiricist version of the causal theory of perception. However, it will be argued that, despite the key role the sign-theory played in his epistemology, Schlick thought the Kantianism in Helmholtz' thought was deeply flawed, rendered obsolete by philosophical insights which emerged from recent scientific developments. So even though Schlick embraced the sign-theory, he rejected Helmholtz' ideas about spatial intuition. In fact, like his teacher, Max Planck, Schlick generalized the sign-theory into a form of structural realism. At the same time, Schlick borrowed the method of concept-formation developed by the formalist mathematicians, Moritz Pasch and David Hilbert, and combined it with the conventionalism of Henri Poincaré. Then, to link formally defined concepts with experience, Schlick's introduced his ‘method of coincidences’, similar to the ‘point-coincidences’ featured in Einstein's physics. The result was an original scientific philosophy, which owed much to contemporary scientific thinkers, but little to Kant or Kantianism.     

From endoderm to pancreas: a multistep journey

The formation of the vertebrate pancreas is a complex process that typifies the basic steps of embryonic development. It involves the establishment of competence, specification, signaling from neighboring tissues, morphogenesis, and the elaboration of tissue-specific genetic networks. A full analysis of this multistep process will help us to understand classic principles of embryonic development. Furthermore, this will provide the blueprint for experimental programming of pancreas formation from embryonic stem cells in the context of diabetes cell-therapy. Although in the past decade many studies have contributed to a solid foundation for understanding pancreatogenesis, important gaps persist in our knowledge of early pancreas formation. This review will summarize the current understanding of the early mechanisms coming into play to pattern the "pre-pancreatic" region within the endoderm and, gradually, specify the pancreatic tissue.     

From Bacon to Banks: the vision and the realities of pursuing science for the common good

Francis Bacon's call for philosophers to investigate nature and "join in consultation for the common good" is one example of a powerful vision that helped to shape modern science. His ideal clearly linked the experimental method with the production of beneficial effects that could be used both as "pledges of truth" and for "the comforts of life." When Bacon's program was implemented in the following generation, however, the tensions inherent in his vision became all too real. The history of the Royal Society of London, from its founding in 1660 to the 42-year presidency of Joseph Banks (1778-1820), shows how these tensions led to changes in the way in which both the experimental method and the ideal of the common good were understood. A more nuanced understanding of the problems involved in recent philosophical analyses of science in the public interest can be achieved by appreciating the complexity revealed from this historical perspective.     

From 'beastly philosophy' to medical genetics: eugenics in Russia and the Soviet Union

This essay offers an overview of the three distinct periods in the development of Russian eugenics: Imperial (1900-1917), Bolshevik (1917-1929), and Stalinist (1930-1939). Began during the Imperial era as a particular discourse on the issues of human heredity, diversity, and evolution, in the early years of the Bolshevik rule eugenics was quickly institutionalized as a scientific discipline--complete with societies, research establishments, and periodicals--that aspired an extensive grassroots following, generated lively public debates, and exerted considerable influence on a range of medical, public health, and social policies. In the late 1920s, in the wake of Joseph Stalin's 'Great Break', eugenics came under intense critique as a 'bourgeois' science and its proponents quickly reconstituted their enterprise as 'medical genetics'. Yet, after a brief period of rapid growth during the early 1930s, medical genetics was dismantled as a 'fascist science' towards the end of the decade. Based on published and original research, this essay examines the factors that account for such an unusual--as compared to the development of eugenics in other locales during the same period--historical trajectory of Russian eugenics.     

Vacuolar H+-ATPase: From mammals to yeast and back

Vacuolar H⁺-adenosine triphosphatase (V-ATPase) is composed of distinct catalytic (V₁) and membrane (V₀) sectors containing several subunits. The biochemistry of the enzyme was mainly studied in organelles from mammalian cells such as chromaffin granules and clathrin-coated vesicles. Subsequently, mammalian cDNAs and yeast genes encoding subunits of V-ATPase were cloned and sequenced. The sequence information revealed the relation between V- and F-ATPases that evolved from a common ancestor. The isolation of yeast genes encoding subunits of V-ATPase opened an avenue for molecular biology studies of the enzyme. Because V-ATPase is present in every known eukaryotic cell and provides energy for vital transport systems, it was anticipated that disruption of genes encoding V-ATPase subunits would be lethal. Fortunately, yeast cells can survive the absence of V-ATPase by drinking the acidic medium. So far only yeast cells have been shown to be viable without an active V-ATPase. In contrast to yeast, mammalian cells may have more than one gene encoding each of the subunits of the enzyme. Some of these genes encode tissue- and/or organelle-specific subunits. Expression of these specific cDNAs in yeast cells may reveal their unique functions in mammalian cells. Following the route from mammals to yeast and back may prove useful in the study of many other complicated processes.     

From carrot to clinic: an overview of the retinoic acid signaling pathway

Vitamin A is essential for the formation and maintenance of many body tissues. It is also important for embryonic growth and development and can act as a teratogen at critical periods of development. Retinoic acid (RA) is the biologically active form of vitamin A and its signaling is mediated by the RA and retinoid X receptors. In addition to its role as an important molecule during development, RA has also been implicated in clinical applications, both as a potential anti-tumor agent as well as for the treatment of skin diseases. This review presents an overview of how dietary retinoids are converted to RA, hence presenting the major players in RA metabolism and signaling, and highlights examples of treatment applications of retinoids. Moreover, we discuss the origin and diversification of the retinoid pathway, which are important factors for understanding the evolution of ligand-specificity among retinoid receptors.     

The double transfer of thermodynamics: From physics to chemistry and from Europe to America

The aim of this study is twofold: to explore, first, the influence of the intellectual and social conditions on the transfer of thermodynamics to chemistry and thereby the making of chemical thermodynamics, and second, the way that this knowledge was transferred from Europe to America. Consequently, it is of interest to examine the methodological approaches used by physicists and chemists to transfer thermodynamics to chemistry, to evaluate the potential of this science to offer solutions to existing chemical problems, and to discuss the attitude of the scientific community towards these new ideas. The development of chemical thermodynamics in America followed a different route compared to the European experience. Although it was transferred from Europe, it had distinctive characteristics imposed by a different traditional, intellectual and social milieu. This study focuses on the content of the transferred knowledge to America and the direction that this knowledge assumed by the American scientists. As a paradigm, the chemical thermodynamics of Gilbert Newton Lewis will be considered.