On the Virtues and Disadvantage of Quantification for Democratic Life

In this paper, a response to Ed Levy's discussion of medical quantification, I reflect on the ambitions of my book Trust in Numbers. I explore the idealized method of randomized clinical trials, revealed in his case study, as a social technology, one endowed with a persuasive scientific rationale but shaped also by political and social demands. The scholarly study of quantification requires not a choice between blind admiration and sweeping rejection, but a nuanced understanding. This should take into account not only the cognitive aspects of science, but also its role in relation to institutions and customs, examined with some specificity. While history is narrowed and distorted when it is written to support a position on some present issue, historical and social studies of science should at least provide tools of criticism. For this, the historian of science must look beyond narrow communities of specialists, and seek a wider perspective on science as an administrative tool and a bearer of cultural and political values.     

Introduction to values and pluralism in the environmental sciences: From inferences to institutions

Philosophers of science continue to elaborate our understanding of the roles that values play in scientific reasoning, practice, and institutions. This special issue focuses on the environmental sciences, a mosaic of fields ranging from restoration ecology to forestry to climatology, unified by its attention to the relationships between humans and their habitats. It is a field that revolves around ameliorating environmental problems, aiming to support the provision of social goods and provide guidance to policymakers about how to regulate individuals and industries. Values abound in such judgments as setting the boundaries of an ecosystem, integrating the human dimensions of social-ecological systems, and collaborating with stakeholders. Since few in the field are likely to insist that these judgments can be made without reference to social values, environmental science can serve as fertile ground for exploring the ethical, social, and political terrain at the frontier of the science and values discourse.     

The ontology of artefacts: the hard problem

We examine to what extent an adequate ontology of technical artefacts can be based on existing general accounts of the relation between higher-order objects and their material basis. We consider two of these accounts: supervenience and constitution. We take as our starting point the thesis that artefacts have a ‘dual nature’, that is, that they are both material bodies and functional objects. We present two criteria for an adequate ontology of artefacts, ‘Underdetermination’ (UD) and ‘Realizability Constraints’ (RC), which address aspects of the dual nature thesis. Assessing supervenience accounts, we find them either wanting with respect to these criteria or insufficiently informative. Next, we argue that a recent application of Lynne Rudder Baker’s constitution view to artefacts cannot (yet) meet our criteria, although the broader view leaves room for improvement. Based on our evaluation of the most promising candidates, we conclude that so far general metaphysical views fail to address the most salient features of artefacts. Although they can account for the fact that artefacts have a ‘dual nature’, they do not offer the conceptual resources needed to describe the relation between these natures; this relation raises a hard problem in metaphysics.     

科技政策、科研管理评论与报道

中美医学科学研究体系与管理有以下特点 :(1)资助和管理的政府机构 ,我国主要有国家科学技术部、国家自然科学基金委员会和国家卫生部 ;美国主要是国立卫生院 (NationalInstitutesofHealth ,NIH)。 (2 )项目的资助模式上 ,我国为“3+ 2”计划体系 ,即三大项目体系 (国家高技术研究发展项目计划 ,国家科技攻关计划和基础研究计划 )和两大科技平台条件建设体系 (研究开发条件建设计划和科技产业化环境建设计划 ) ,不同基金资助基础到产业化研究的不同阶段和类别 ;NIH基金按疾病领域、经费和院内、外研究机构 ,从基础、应用基础和平台条件建设以及产业化整体系统资助。 (3)管理和运行模式上 ,我国有两种模式 ,一是国家部委到地方科委再到高校和科研院所 ,二是国家部委直接到各高校和科研院所 ;NIH直接到高校和各科研院所。 (4)基金的构成特点上 ,我国医学科学研究来自三大项目和两大条件计划体系的每个部分 ,申请项目必须根据项目研究的不同性质和阶段找准计划体系中不同计划的特定资助方向 ;NIH基金系统支持医学研究的各个领域和不同研究阶段。 (5 )经费的投入上 ,我国医学科研经费投入约占总科研经费投入的 2 0 %左右 ,历年投入总和只相当于NIH一年经费的几十分之一。 (6 )规划计划上 ,NIH宏观和微观相结     

The abundant world: Paul Feyerabend's metaphysics of science

The goal of this paper is to provide an interpretation of Feyerabend's metaphysics of science as found in late works like Conquest of Abundance and Tyranny of Science. Feyerabend's late metaphysics consists of an attempt to criticize and provide a systematic alternative to traditional scientific realism, a package of views he sometimes referred to as “scientific materialism.” Scientific materialism is objectionable not only on metaphysical grounds, nor because it provides a poor ground for understanding science, but because it implies problematic claims about the epistemic and cultural authority of science, claims incompatible with situating science properly in democratic societies. I show how Feyerabend's metaphysical view, which I call “the abundant world” or “abundant realism,” constitute a sophisticated and challenging form of ontological pluralism that makes interesting connections with contemporary philosophy of science and issues of the political and policy role of science in a democratic society.     

韩国科技管理体制发展与演变探析

自20世纪60年代以来,韩国的科技发展取得了巨大的成就,其科技管理体制发挥了重要的作用.针对韩国科技管理体制形成与发展演变过程中经历的科技管理体系初步形成,以科技部为宏观管理决策部门的集中协调型管理体制,以及李明博政府对科技管理体制的重大调整等三个重要阶段进行了系统的分析研究,并对韩国科技管理体制的特点进行了总结和讨论.     

Rip it up and start again: The rejection of a characterization of a phenomenon

In this paper, I investigate the nature of empirical findings that provide evidence for the characterization of a scientific phenomenon, and the defeasible nature of this evidence. To do so, I explore an exemplary instance of the rejection of a characterization of a scientific phenomenon: memory transfer. I examine the reason why the characterization of memory transfer was rejected, and analyze how this rejection tied to researchers’ failures to resolve experimental issues relating to replication and confounds. I criticize the presentation of the case by Harry Collins and Trevor Pinch, who claim that no sufficient reason was provided to abandon research on memory transfer. I argue that skeptics about memory transfer adopted what I call a defeater strategy, in which researchers exploit the defeasibility of the evidence for a characterization of a phenomenon.     

Putting pragmatism to work in the Cold War: Science, technology, and politics in the writings of James B. Conant

This paper examines James Conant’s pragmatic theory of science—a theory that has been neglected by most commentators on the history of 20^th-century philosophy of science—and it argues that this theory occupied an important place in Conant’s strategic thinking about the Cold War. Conant drew upon his wartime science policy work, the history of science, and Quine’s epistemological holism to argue that there is no strict distinction between science and technology, that there is no such thing as “the scientific method,” and that theories are better interpreted as policies rather than creeds. An important consequence that he drew from these arguments is that science is both a thoroughly value-laden, and an intrinsically social, enterprise. These results led him to develop novel proposals for reorganizing scientific and technological research—proposals that he believed could help to win the Cold War. Interestingly, the Cold War had a different impact upon Conant’s thinking than it did upon many other theorists of science in postwar America. Instead of leading him to “the icy slopes of logic,” it led him to develop a socially- and politically-engaged theory that was explicitly in the service of the American Cold War effort.     

The x-phi(les): unusual insights into the nature of inquiry

Experimental philosophy is often regarded as a category mistake. Even those who reject that view typically see it as irrelevant to standard philosophical projects. We argue that neither of these claims can be sustained and illustrate our view with a sketch of the rich interconnections with philosophy of science.     

Spectroscopy of aqueous solutions: protein and DNA interactions with water

This review emphasises the need to use spectroscopy in order to understand the behaviour of water, and summarises the background of the subject. The various forms of spectroscopy that are especially informative are described, with particular reference to near-infrared (NIR) spectrophotometry. The key results are outlined, first those obtained with small molecules and ions, and second those involving proteins, DNA and cell membranes. Finally, some interpretations are offered which include the novel but possibly controversial concept of free OH and free lone-pair groups.     

The scales of experience: Introduction to the special issue Experiencing the global environment

The Scales of Experience introduces the special issue Experiencing the Global Environment by focusing on three dimensions of the theme that are reflected to various degrees in the constitutive essays. First, the introduction highlights the links between the epistemological and political contexts of the historical constitution and development of the global environment (or global environments) in the earth and environmental sciences from the late nineteenth century to today. Second, it argues for a historical approach to the complex concept of scientific experience, whose mutable and contingent qualities are demonstrated by the contributions to the special volume. Lastly, the introduction presents one of the central issues to be tackled by the essays to follow: the development – and, at times, the failure – of strategies and technologies to bridge the seemingly incommensurate gulf between individual, localized experience and the all-encompassing scale of the global environment.     

Science,politics and regulation: The trust-based approach to the demarcation problem

Drawing on literature on values in science and a case-study of UK cancer policy, this paper argues for a novel account of the demarcation project in terms of trustworthiness. The first part of the paper addresses the relationship between science, politics and demarcation. In 2010, the UK government decided to pay more for cancer drugs than for drugs for other diseases; in 2016, this Cancer Drugs Fund was reformed so as to lower the evidential standards for approving cancer drugs, rather than paying more for them. Are these two ways of treating cancer as “special” importantly different? This paper argues that, if we the argument from inductive risk seriously, they seem equivalent. This result provides further reason to doubt the notion of demarcating science from non-science. However, the second part of the paper complicates this story, arguing that considerations of epistemic trust might give us reasons to prefer epistemic communities centred around “broadly acceptable” standards, and which are “sociologically well-ordered”, regardless of inductive risk concerns. After developing these claims through the cancer case-study, the final section suggests how these concerns might motivate novel versions of the demarcation project.     

Structure-based models of cadherin-mediated cell adhesion: the evolution continues

Cadherins are glycoproteins that are responsible for homophilic, Ca²⁺-dependent cell-cell adhesion and play crucial roles in many cellular adhesion processes ranging from embryogenesis to the formation of neuronal circuits in the central nervous system. Many different experimental approaches have been used to unravel the molecular basis for cadherin-mediated adhesion. In particular, several high-resolution structures have provided models for cadherin-cadherin interactions that are illuminative in many respects yet contradictory in others. This review gives an overview of the structural studies of cadherins over the past decade while focusing on recent developments that reconcile some of the earlier findings.Received 7 January 2004; received after revision 24 February 2004; accepted 4 March 2004     

The role of interactional expertise in interpreting: the case of technology transfer in the steel industry

I analyse the case of three Japanese-Portuguese interpreters who have given support to technology transfer from a steel company in Japan to one in Brazil for more than thirty years. Their job requires them to be ‘interactional experts’ in steel-making. The Japanese–Portuguese interpreters are immersed in more than the language of steel-making as their job involves a great deal of ‘physical contiguity’ with steel-making practice. Physical contiguity undoubtedly makes the acquisition of interactional expertise easier. This draws attention to the lack of empirical work on the exact way that the physical and the linguistic interact in the acquisition of interactional expertise, or any other kind of expertise.     

美国气候变化技术计划(CCTP)新战略规划及其对我国的启示

美国气候变化技术计划(CCTP)于2006年9月公布了新的气候变化技术计划战略规划,新规划将通过捕集、减少以及储存的方式来控制温室气体的排放量。该计划中包含的技术有氢能源、生物提炼、清洁煤、碳储存、核分裂和聚变能等,这些技术以最基础的方式转化为国民经济价值,不仅能够改善气候变化,而且可以保证能源安全、空气污染以及其他紧迫需求。本文对美国气候变化技术计划战略规划的任务、目标、方法进行概要介绍,并论述了其对我国气候变化技术发展的重要启示。     

The effect of corticotropin-releasing factor and pro-opiomelanocortin-derived peptides on the phagocytosis of molluscan hemocytes

The effect of corticotropin-releasing factor (CRF) and pro-opiomelanocortin (POMC)-derived peptides on hemocyte phagocytosis in two molluscs,Planorbarius corneus andViviparus ater was studied. The peptides and related fragments examined are those which have been shown to influence hemocyte motility in the two species. The results obtained revealed that the effects on phagocytosis are not directly correlated with previous findings on cell motility. Furthermore, the mode of action of an individual peptide could be species-specific and dose-dependent. The relationships between peptides, locomotion and phagocytosis in these molluscs are discussed.     

国内外环境材料最新研究进展

介绍了环境材料的概念,对近期国内外在环境材料理论和应用研究领域取得的进展进行了综述,指出了未来环境材料研究的发展方向。     

Pink lateral muscle in the carp (Cyprinus carpio L.): histochemical properties and myosin composition

Summary The pink muscle of the carp differs from the white (and red) muscle not only histochemically but also in its myosin isoform, as shown by peptide maps of the myosin heavy chains. Results of an electrophoretic analysis of myosins are discussed in the light of their immunohistochemical properties and histochemical ATPase activity.Work supported by the M.P.I. (40%).     

Thomas Reid and the problem of induction: from common experience to common sense

By the middle of the eighteenth century the new science had challenged the intellectual primacy of common experience in favor of recondite, expert and even counter-intuitive knowledge increasingly mediated by specialized instruments. Meanwhile modern philosophy had also problematized the perceptions of common experience — in the case of David Hume this included our perception of causal relations in nature, a fundamental precondition of scientific endeavor.In this article I argue that, in responding to the ‘problem of induction’ as advanced by Hume, Reid reformulated Aristotelian foundationalism in distinctly modern terms. An educator and mathematician self-consciously working within the framework of the new science, Reid articulated a philosophical foundation for natural knowledge anchored in the human constitution and in processes of adjudication in an emerging modern public sphere of enlightened discourse. Reid thereby transformed one of the bases of Aristotelian science — common experience — into a philosophically and socially justified notion of ‘common sense’. Reid's intellectual concerns had as much to do with the philosophy of science as they did with moral philosophy or epistemology proper, and were bound up with wider social and scientific changes taking place in the early modern period.     

Carl du Prel (1839–1899): explorer of dreams, the soul, and the cosmos

Nineteenth-century spiritism was a blend of religious elements, the philosophy of mind, science and popular science and contacts with extraterrestrials were a commonplace phenomenon during spiritistic séances. Using the example of Carl du Prel (1839–1899) I show how his comprehensive mystic philosophy originated in a theory of extraterrestrial life. Carl du Prel used a Darwinian and monistic framework, theories of the unconscious and a Neo-Kantian epistemology to formulate a philosophy of astronomy and extraterrestrial life. He claimed that the mechanism of Darwinian selection is responsible for the distribution of stars and the orbits of the planets. In his speculations on the nature of extraterrestrial life he used the concept of organ projection to argue that technical solutions on earth will be realized organically on other planets and claimed that superior extraterrestrials have quantitatively and qualitatively different senses and thus different forms of intuition. A comparison with Camille Flammarion, spiritist and populariser of astronomy, demonstrates the contextual complexities of spiritism. In contrast to du Prel’s sober Neo-Kantian philosophical speculations, Flammarion was a late proponent of a French esoteric tradition that was rooted in romantic socialism, painted grand cosmological vistas and emphasized reincarnation. I put forward the hypothesis that current discourses on extraterrestrial life are affected by the spiritist tradition mainly through the ‘Golden Age’ science fiction literature of the 1940s and 50s and its successors. However, neither Carl du Prel nor Camille Flammarion contributed significantly to this tradition, which is mainly shaped by the psychical research of J. B. Rhine.