Brain norepinephrine levels and turnover rates in castrated mice isolated for 13 months

Zusammenfassung Funktionsdynamik von Gehirn-Norepinephrin (NE) in kastrierten und scheinkastrierten männlichen, geschlechtsreifen (C57Br/6J)-Mäusen wurde nach 13 Monaten Isolierung untersucht. Kastrierung bewirkt starken Abfall des ursprünglichen Niveaus und der Stoffwechselgeschwinddigkeit von NE.

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Supported in part by a USPHS Predoctoral Fellowship toB. K. Bernard and NIMH Grant No. MH 15352 toR. M. Paolino.     

A study of the enzyme activity in the seminal vesicles of castrated and hormone-replaced castrated mice.

Castration provokes a time-related decrease in weight, protein, beta-glucuronidase and glucose-6-phosphate dehydrogenase activity of seminal vesicles. A dose-dependent stimulation of these parameters is obtained with 5alpha-DHT. Cryproterone acetate counteracts the stimulatory effects due to androgen. Acid and alkaline phosphatases remain largely unaffected by these treatments.     

Formation of norepinephrine from tyrosine in isolated rabbit heart

Zusammenfassung Die Bildung des Noradrenalins aus Tyrosin konnte im isolierten Kaninchenherzen nachgewiesen werden. Die Reaktion scheint für Tyrosin spezifisch zu sein. Aus Tyramin wurde kein Noradrenalin gebildet. Ebenfalls wurde die Umwandlung von Tyramin in Norsynephrin und von Dopamin in Noradrenalin nachgewiesen.     

Effect of lidoflazine on norepinephrine,angiotensin and serotonin responses in isolated smooth muscle preparations

Résumé Les effets de la lidoflazine ont été étudiés sur les bandelettes aortiques isolées du lapin et les bandelettes gastriques isolées du rat. La lidoflazine antagonise significativement la sérotonine sur ces 2 préparations sans altérer leurs réponses à l'angiotensine et à la noradrénaline.     

Comparison of diurnal and nocturnal rates of 5-hydroxytryptamine turnover in the rat mediobasal hypothalamus

Rates of 5-hydroxytryptamine (5-HT) turnover in the mediobasal hypothalamus of male rats were estimated using pharmacological methods during the daytime and at night. Concentrations of 5-HT in this hypothalamic area were higher nocturnally than diurnally; this was apparently due to increased 5-HT synthesis and decreased 5-HT catabolism at night.     

Comparison of diurnal and nocturnal rates of 5-hydroxytryptamine turnover in the rat mediobasal hypothalamus

Summary Rates of 5-hydroxytryptamine (5-HT) turnover in the mediobasal hypothalamus of male rats were estimated using pharmacological methods during the daytime and at night. Concentrations of 5-HT in this hypothalamic area were higher nocturnally than diurnally; this was apparently due to increased 5-HT synthesis and decreased 5-HT catabolism at night.Supported by NIH grant RR07187 (TSK) and NIH grant HD10202 (Neuroendocrine Core).     

Erythropoiesis and plasma tocopherol levels in irradiated mice

Summary Plasma protein and tocopherol concentrations, haematocrit and 59-iron incorporation into erythrocytes have been measured in vitamin E-deficient and supplemented mice before and after exposure to 500 R of 260 kVp X-ray. Supplemented animals had greater haematocrit, plasma tocopherol and protein levels initially. After irradiation plasma tocopherol concentration decreased drastically in the vitamin E-supplemented mice.     

Responses of isolated blood vessels to acetylcholine,epinephrine, norepinephrine,and histamine

Zusammenfassung Acetylcholin verursachte in den Coronar-, Femoral- und Mesenterialarterien, Catecholamine in den Femoral- und Mesenterialgefässen Konstriktionen, in den Coronargefässen hingegen Dilatation.

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This work was completed in the Department of Physiology, University of Mississippi Medical Center, Jackson (Mississippi USA).     

The effect of exercise on protein turnover in isolated soleus and extensor digitorum longus muscles

The rate of protein degradation was found to be increased in isolated soleus and extensor digitorum muscles of 60-80 g rats after exercise consisting of running for 120 min. These findings support the hypothesis that exercise causes an increase in skeletal muscle protein degradation, and that both red and white muscles are affected similarly.     

The effect of exercise on protein turnover in isolated soleus and extensor digitorium longus muscles

Summary The rate of protein degradation was found to be increased in isolated soleus and extensor digitorum muscles of 60–80 g rats after exercise consisting of running for 120 min. These findings support the hypothesis that exercise causes an increase in skeletal muscle protein degradation, and that both red and white muscles are affected similarly.     

Plasma hormone levels in normal and lead-treated pregnant mice

Summary Dietary lead (0.5%) was given to mice which, after mating, exhibited a vaginal plug. Estradiol, progesterone and prostaglandins E and F 2 were determined in, the plasma by radioimmuno assay at different times thereafter. The increase in estradiol and decrease in prostaglandins prior implantation are not greatly altered by lead treatment, whereas the subsequent increase in progesterone and later in estradiol is abolished. It is concluded that the lower number of pregnancies seen in lead-treated mothers is due to a maternal hormonal imbalance caused by lead.Supported by contract 038-74-7 ENV B of the E.C. Environmental Research Program. Publication No. 1394 of the Euratom Biology Division.     

Adrenal relationships to aggressiveness in isolated female mice

Résumé Lorsque des souris femelles soumises à l'isolement sont groupées selon leur tempérament belliquex et non-belliqueux, on observe une augmentation de l'activité médullossurrénalienne chez les animaux isolés belliquex. Au contraire, les souris isolées non-belliqueuses ont montré des taux de catécholamines inférieurs et une secrétion cortico-surrénale nettement augmentée.

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Submitted byRalph Schwartz to the faculty of Richard L. Connelly College, Long Island University in partial fulfillment of the requirements for the Degree of Masters of Science.     

Independence of circulating insulin levels of the increased glucose turnover in shivering dogs

Summary In dogs, selective insulin deficiency induced by simultaneous somatostatin and glucagon infusion does not alter the high rate of glucose utilization provoked by acute cold exposure. However, both in resting and in shivering dogs, lowering of plasma insulin decreases plasma glucose metabolic clearance significantly.