子宫内膜异位症临床病理特点及发病机制探讨

目的:分析子宫内膜异位症的临床病理特点及探讨子宫内膜异位症的病因及发病机制.方法:根据病变部位的不同,将子宫内膜异位症分为:(1)内在性子宫内膜异位症;(2)外在性子宫内膜异位症;(3)混合性子宫内膜异位症.应用免疫组织化学S-P法,对112例子宫内膜异位症在位及异位内膜组织进行雌、孕激素受体的测定.结果:子宫内膜异位症的临床特点为慢性盆腔疼痛、痛经和不孕;连续切片证实内在性子宫内膜异位症来源于内膜基底层的腺体和间质.雌激素受体(ER)在在位及异位内膜组织中的阳性率分别为89%(39/44)和80%(45/56);孕激素受体(PR)在在位和异位内膜的阳性率分别为77%(34/44)和86%(48/56);两者均无统计学差异(P>0.05).结论:子宫内膜异位症是由多种原因引起的一种良性病变,但也具有种植、转移等肿瘤组织的特点.内在性子宫内膜异位症来源于内膜基底层的腺体和间质.ER、PR在异位症的在位及异位内膜组织中均有较高的阳性表达,表明其直接或间接地参与了子宫内膜异位症的发病过程,对其发生和发展起重要作用.     

子宫内膜异位症的免疫功能研究(综述)

近年来关于子宫内膜异位症的免疫功能研究取得了显著进展，本文对子宫内膜异位症的免疫发病机制、免疫细胞、自身免疫反应以及丹那唑对子内膜异位症免疫功能的影响进行了综述。     

会阴、腹壁子宫内膜异位症13例临床分析

目的:探讨会阴、腹壁子宫内膜异位症的发生原因及治疗。方法:回顾性分析13例会阴、腹壁子宫内膜异位症的临床资料进行总结。结果:11例会阴子宫内膜异位症(占84.61%) ,1例为腹壁剖宫产切口子宫内膜异位症(占7.69%) ,1例为无创伤史的左侧腹直肌前鞘内膜异位症(占7.69%)。最早发病者为产后7a,最晚为产后10a,平均6.2a。12例在切口处有痛性结节 ,大小与月经周期有关 ,仅有1例无任何临床表现。结论:会阴、腹壁伤口子宫内膜异位症的发生重在预防 ,应尽量避免宫腔操作引起的子宫内膜医原性播散。治疗以手术切除异位病灶为主     

米非司酮治疗子宫内膜异位症的研究进展

子宫内膜异位症是常见的妇科疾病,其发病机制还未完全阐明,给临床治疗带来很大的困难,目前国内外有关于小剂量的米非司酮治疗子宫内膜异位症的报道,其治疗效果较理想,且副作用小,是较有前途的一种药物,但机制不明.     

丹那唑对大鼠子宫内膜异位症IL-6水平的影响

目的：检测子宫内膜异位症大鼠在位和异位内膜的白细胞介素6（IL-6）水平及丹那唑对IL-6水平的影响，探讨IL-6在子宫内膜异位症发病 中的作用。方法：参照Jones方法建立大鼠子宫内膜异位症动物模型，采用ELISA法检测子宫内膜IL-6水平。结果：模型组异位内膜的IL-6水平比在位内膜显著降低，而丹那唑治疗组在位和异位内膜的IL-6水平显著高于模型组的在位和异位内膜。结论：子宫内膜异位症异位内膜的生长与IL-6水平的降低有关，丹那唑治疗子宫内膜异位症的机理可能部分地通过升高内膜组织IL-6水平起作用。     

彩色多普勒超声检查对子宫内膜异位症诊断的效果分析

分析彩色多普勒超声（CDFI）检查对子宫内膜异位症诊断的效果。选取秦安县妇幼保健院收治的60例子宫内膜异位症患者作为研究对象,对患者进行彩色多普勒超声检查,与病理检查结果比较,分析内异症分期诊断率、超声诊断率及不同病灶大小的超声图像特征。不同大小病灶间直径、潜伏期、CDFI血流、病灶深度及强回声等比较差异具有统计学意义（P<0.05）;本研究60例子宫内膜异位症患者诊断阳性率为96.25%(77/80),轻、中、重型子宫内膜异位症诊断符合率分别为78.72%、90.00%、100.00%,总体诊断符合率为83.75%。彩色多普勒超声检查用于诊断子宫内膜异位症不仅可发现病灶,还能确定病变范围,分期诊断符合率及阳性诊断率较高,作为诊断子宫内膜异位症的首选方式具有较高价值。     

子宫内膜异位症的在位与异位内膜研究

论述了子宫内膜异位症在位与异位内膜的差异及发病机理.     

子宫内膜异位疾病121例临床病理分析

总结分析子宫内膜异位症和子宫腺肌病的临床病理特点,以提高这类病变诊断准确率,降低漏诊率。观察121例子宫内膜异位疾病的临床表现,病理特征及术前术后诊断对比。子宫内膜异位疾病最常见的发病部位为子宫肌层,占52.9%(64/121),最常见的临床表现是月经异常(包括合并痛经),占63.2%(76/121),临床诊断符合率仅为21.3%(25/121)。子宫内膜异位疾病包括子宫内膜异位症及子宫腺肌病,此疾病术前术后诊断的吻合率较低,确诊需术后病理检查。临床应提高对本病的重视,结合病史、临床症状和必要的盆腔检查,进行综合判断以减少误诊。     

米非司酮对大鼠子宫内膜异位症芳香化酶表达的影响

目的探讨芳香化酶P450与子宫内膜异位症(内异症)的关系及米非司酮治疗内异症的机制。方法建立大鼠子宫内膜异位症动物模型,将大鼠随机分为3组,即空白组(未建立模型组)、对照组及米非司酮药物组。利用免疫组织化学方法,观察各组异位内膜中芳香化酶(P450 arom)的表达。结果健康大鼠子宫内膜中无P450 arom的表达,内异症模型鼠在位、异位内膜中均出现P450 arom的异常表达;米非司酮药物治疗组异位内膜中P450 arom的表达明显低于对照组异位内膜(P<0.01)。结论大鼠子宫内膜异位症异位内膜中存在P450 arom的异常表达,米非司酮治疗内异症的机制可能与抑制异位内膜中P450 arom的表达,减少异位内膜局部雌激素产生有关。     

米非司酮对大鼠子宫内膜异位症芳香化酶表达的影响

目的 探讨芳香化酶P450与子宫内膜异位症(内异症)的关系及米非司酮治疗内异症的机制.方法 建立大鼠子宫内膜异位症动物模型,将大鼠随机分为3组,即空白组(未建立模型组)、对照组及米非司酮药物组.利用免疫组织化学方法,观察各组异位内膜中芳香化酶(P450 arom)的表达.结果 健康大鼠子宫内膜中无P450 arom的表达,内异症模型鼠在位、异位内膜中均出现P450 arom的异常表达;米非司酮药物治疗组异位内膜中P450 arom的表达明显低于对照组异位内膜(P＜0.01).结论 大鼠子宫内膜异位症异位内膜中存在P450 arom的异常表达,米非司酮治疗内异症的机制可能与抑制异位内膜中P450 arom的表达,减少异位内膜局部雌激素产生有关.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with     

Journal of Donghua University ( English Edition) Contents of Volume 31

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