共查询到20条相似文献,搜索用时 31 毫秒
1.
dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals. 相似文献
2.
J Y Detaille C G Caillard S Mondot J C Louis L Julou 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(5):555-558
In the Dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (RS, SR) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. Furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. The first clinical studies of this compound have shown its usefulness in the treatment of ventricular and supraventricular arrhythmias. 相似文献
3.
V. P. Arya R. S. Grewal C. L. Kaul S. P. Ghate 《Cellular and molecular life sciences : CMLS》1971,27(10):1186-1187
Zusammenfassung 3-[4-(p-Fluorphenyl)-1,2,3,6-te-trahydro-1-pyridyl]-1-[1-(2-hydroxyaethyl)-5-methyl-4-pyrazolyl]-1-propanon (I, CIBA 4416/B-Go) senkt bei normotonischen und hypertonischen Tieren den Blutdruck. Die Drucksenkung kann hauptsächlich auf die periphere Vasodilatation sowie auf die Vasomotorenzentren bezogen werden. Ausserdem wirkt CIBA 4416/B-Go adrenolytisch.
Previous paper:V. P. Arya, R. S. Grewal, C. L. Kaul, S. P. Ghate, D. V. Mehta andT. George, J. Pharm. Sci.58, 432 (1969).Contribution No. 243 from CIBA Research Centre. 相似文献
Previous paper:V. P. Arya, R. S. Grewal, C. L. Kaul, S. P. Ghate, D. V. Mehta andT. George, J. Pharm. Sci.58, 432 (1969).Contribution No. 243 from CIBA Research Centre. 相似文献
4.
The synthesis and antischistosome properties of 5-(hydroxyimino)-4-methoxy-2-(pivaloylimino)thiazolidine-3- acetamide (1) are described. The compound was prepared by reduction of the nitrothiazoline (2) with stannous chloride in methanol, and represents the first example of a reduced nitroheterocyclic compound showing potent schistosomicidal properties. The possible relationship of compounds such as 1 to the as yet unidentified reduced active but toxic entities formed in vivo from nitroheterocyclics like metronidazole is discussed. 相似文献
5.
V. P. Arya R. S. Grewal J. David C. L. Kaul 《Cellular and molecular life sciences : CMLS》1967,23(7):514-515
Zusammenfassung 1-(5-Methyl-1-phenyl-4-pyrazolyl)-3-[4-(o-tolyl)-piperazinyl]-1-propanone (I; CIBA 1002-Go), senkt an normotonischen und hypertonischen Tieren den Blutdruck. Die Drucksenkung kann auf eine periphere Vasodilatation und eine Hemmung hypothalamischer oder medullärer Vasomotorenzentren bezogen werden. Ausserdem wirkt CIBA 1002-Go adrenolytisch.
Hydrochloride = CIBA 1002-Go. 相似文献
Hydrochloride = CIBA 1002-Go. 相似文献
6.
Zusammenfassung 1-Allylund 1-Crotyl-2-(oxy-benzyl)-Benzimidazol hemmen die Vermehrung von Poliovirus 1, 2 und 3, sowie diejenige der Coxsackieviren A 9 und A 21 und diejenige des ECHO-Virus 11. 相似文献
7.
P. J. Islip M. V. Bogunović-Batchelor 《Cellular and molecular life sciences : CMLS》1985,41(10):1353-1354
Summary The synthesis and antischistosome properties of 5-(hydroxyimino)-4-methoxy-2-(pivaloylimino)thiazolidine-3-acetamide (1) are described. The compound was prepared by reduction of the nitrothiazoline (2) with stannous chloride in methanol, and represents the first example of a reduced nitroheterocyclic compound showing potent schistosomicidal properties. The possible relationship of compounds such as1 to the as yet unidentified reduced active but toxic entities formed in vivo from nitroheterocyclics like metronidazole is discussed.Acknowledgments. The authors are grateful to Dr A. J. Everett and his staff for the physical chemistry measurements, and to Mr G. Dickerson for the antischistosome testing. 相似文献
8.
D. G. O'Sullivan Danica Pantic A. K. Wallis 《Cellular and molecular life sciences : CMLS》1968,24(7):661-663
Zusammenfassung Died-isomere Verbindung ist verantwortlich für die Poliovirus-hemmende Aktivität vondl-5-Chlor-2-(-oxy-benzyl)-benzimidazol.dl-1-Propyl-5-chlor-unddl-1-Butyl-5-chlor-Derivate sind ausserordentlich wirksam zur Verhinderung der Vermehrung der Typen 1, 2 und 3 des Poliovirus; andere 1-Alkyl-5-chlor-Derivate sind ebenfalls aktiv. Die 1-Alkyl-Grundverbindungen sind jedoch wirksamer als deren gleichartige 1-Alkyl-5-chlor-Derivate.
The research is supported by the National Fund for Research into Poliomyelitis and other Crippling Diseases. 相似文献
The research is supported by the National Fund for Research into Poliomyelitis and other Crippling Diseases. 相似文献
9.
V. Amico G. Oriente M. Piattelli C. Tringali E. Fattorusso S. Magno L. Mayol 《Cellular and molecular life sciences : CMLS》1977,33(8):989-990
Summary A novel ether lipid, (-)-(R)-1-O-geranylgeranylglycerol (1), has been isolated from the brown alga Dilophus fasciola and its structure proved by spectroscopic methods and chemical degradation.This work was supported by CNR, Rome, Italy. 相似文献
10.
A. Aiello E. Fattorusso S. Magno G. Misuraca E. Novellino 《Cellular and molecular life sciences : CMLS》1987,43(8):950-952
Summary 2-Amino-6-[(1'R,2'S)-1',2'-dihydroxypropyl]-3-methyl-pterin-4-one (1) has been isolated from the marine anthozoanAstroides calycularis; its structure was illustrated by spectral analyses including 2D-NMR and by partial synthesis.1 appears to possess cell-growth inhibiting activity.29 December 1986Work supported by C.N.R. (Progetto Finalizzato Chimica Fine e Secondaria) and by Ministero Pubblica Istruzione Italy. — Acknowledgments. Mass spectral data were provided by Servizio di Spettrometria di massa del C.N.R. e dell'Università di Napoli. The assistance of the staff is gratefully appreciated. Finally we would like to thank Prof. C. Pietropaolo for supplying chick embryo fibroblasts. 相似文献
11.
Zusammenfassung Synthesen von 9-(2-Deoxy-1-D-glukosyl)-adenin und 1-(9-Adenyl)-pseudo-D-glukal werden beschrieben. Diese Substanzen wirken bei der Maus erheblich antileukämisch. 相似文献
12.
R. K. Razdan A. J. Puttick B. A. Zitko G. R. Handrick 《Cellular and molecular life sciences : CMLS》1972,28(2):121-122
Zusammenfassung Die Synthese von (—)-1(7)-Tetrahydrocannabinol (THC) auf (—)-1(6) wird beschrieben. Das Hauptprodukt der oxidativen Zerstörung von (—)-1-THC ist Cannabinol. Beschleunigte Versuche der Luftoxidation von (—)-1-THC und (—)-1(6)-THC haben gezeigt, dass das letztere beständiger ist. Dieser Unterschied kann mit der Reaktivität des C3-benzylisch-allylischen Wasserstoffes in (—)-1-THC erklärt werden. 相似文献
13.
D. G. O'Sullivan Danica Pantic A. K. Wallis 《Cellular and molecular life sciences : CMLS》1968,24(12):1185-1187
Zusammenfassung 1-Alkyl-2-(-methoxybenzyl)-benzimidazole hemmt die Vermehrung des Poliovirus der Arten 1, 2 und 3, wobei das 1-Propyl-Derivat die grösste Wirkung hat.
The research is supported by the National Fund for Research into Poliomyelitis and other Crippling Diseases. 相似文献
The research is supported by the National Fund for Research into Poliomyelitis and other Crippling Diseases. 相似文献
14.
Studies of the in vivo metabolism of 10,11-dihydrodibenz[b,f]-1,4-oxazepin-11-(1OH)-one (2) specifically deuteriated at C7 implicate an arene oxide intermediate during the conversion to 7-hydroxy-2 (4) as evidenced by the observation of the NIH shift. 相似文献
15.
Summary Evidence for the absolute configuration of (-)-2-dehydroemetine (IV) is presented.
Über die Darstellung der in dieser Mitteilung erwähnten vier optisch aktiven 2-Dehydroemetin-Isomeren und das Resultat ihrer chemotherapeutischen Untersuchung wird in Helv. chim. Acta ausführlich berichtet werden. 相似文献
Über die Darstellung der in dieser Mitteilung erwähnten vier optisch aktiven 2-Dehydroemetin-Isomeren und das Resultat ihrer chemotherapeutischen Untersuchung wird in Helv. chim. Acta ausführlich berichtet werden. 相似文献
16.
Battaglia V Sanz E Salvi M Unzeta M Toninello A 《Cellular and molecular life sciences : CMLS》2006,63(12):1440-1448
PF9601N, N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine, an monoamine oxidase (MAO) B inhibitor, has shown neuroprotective properties
against dopaminergic toxins. To elucidate the mechanisms involved in this protection, the effect of PF9601N on mitochondria
was assessed. PF9601N prevents mitochondrial swelling, drop in the electrical potential and oxidation of sulfhydryl groups,
glutathione and pyridine nucleotides induced by Ca2+. These observations demonstrate the protective effect of PF9601N on the induction of mitochondrial permeability transition.
This protection is due to the interaction of the secondary protonated amino group in the molecule with pore-forming structures
and to its antioxidant property, rather than to inhibition of MAO B activity. PF9601N also prevents the release of cytochrome
c from mitochondria, suggesting its potential inhibitory effect on mitochondria-mediated apoptosis. The low IC50 value for this inhibition, in comparison with deprenyl, make it a more efficient compound than propargylamines and other
amines in protecting the bioenergetic functions of mitochondria.
Received 9 March 2006; received after revision 10 April 2006; accepted 21 April 2006 相似文献
17.
Zusammenfassung Die- Rezeptoren vom Sphinkter von Oddi werden durch Terbutalin selektiv stimuliert. 相似文献
18.
M. Katayama K. Kato H. Kimoto S. Fujii 《Cellular and molecular life sciences : CMLS》1995,51(7):721-724
Racemic 4,4,4-trifluoro-3-(indole-3-)butyric acid (TFIBA) has been synthesized and shown to inhibitAvena coleoptile elongation. (S)-(+)-TFIBA (fig. 1), which was prepared by an enzymatic method and markedly promotes root growth of Chinese cabbage, lettuce and rice plants, is a novel fluorinated plant growth regulator. Activity of the (S)-(+)-enantiomer of TFIBA was 10-fold greater than that of the (R)-(–)-enantiomer in the first two plant species and 5-fold greater in rice. 相似文献
19.
J. M. Harrison R. J. Clarke T. D. Inch D. G. Upshall 《Cellular and molecular life sciences : CMLS》1978,34(6):698-699
Summary Studies of the in vivo metabolism of 10,11-dihydrodibenz[b,f]-1,4-oxazepin-11-(1OH)-one (2) specifically deuteriated at C-7 implicate an arene oxide intermediate during the conversion to 7-hydroxy-2 (4) as evidenced by the observation of the NIH shift. 相似文献
20.
P Leroux M Gredt 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1978,286(5):427-429
Imazalil is a new fungicide effective against Penicillium molds on fruits after harvest. This compound inhibits ergosterol biosynthesis in mycelia of Penicillium expansum. The accumulation of 24--methylenedithydrolanosterol, obtusifoliol and 14 alpha-methyl-delta 8, 24(28)-ergostadienol in treated fungi suggests that imazalil blocks sterol C--14 demethylation. 相似文献