如何发挥刑事犯罪信息资料的服务功能

随着公安机关实行“破案追逃”新机制的建立和“严打”整治斗争的深入开展，对各级公安机关侦查破案中收集资料信息工作提出了新的，更高的要求，新形势下，公安机关刑事侦查破案工作中收集信息资料工作还存在一些问题，限制着刑事犯罪信息资料服务功能的发挥，亟待在今后工作中及时解决。     

如何上好计算机课程的实验课

计算机科学是一门理论性和实践性都很强的学科，计算机理论与实践是密切相关、相辅相承的。因此，上机实验是计算机教学中不可缺少的一个重要环节，它给学生提供了一个理论与实践相结合的机会。结合实践，从五个方面探讨怎样上好计算机实验课。     

Glioblastoma stem-like cells give rise to tumour endothelium

Glioblastoma (GBM) is among the most aggressive of human cancers. A key feature of GBMs is the extensive network of abnormal vasculature characterized by glomeruloid structures and endothelial hyperplasia. Yet the mechanisms of angiogenesis and the origin of tumour endothelial cells remain poorly defined. Here we demonstrate that a subpopulation of endothelial cells within glioblastomas harbour the same somatic mutations identified within tumour cells, such as amplification of EGFR and chromosome 7. We additionally demonstrate that the stem-cell-like CD133(+) fraction includes a subset of vascular endothelial-cadherin (CD144)-expressing cells that show characteristics of endothelial progenitors capable of maturation into endothelial cells. Extensive in vitro and in vivo lineage analyses, including single cell clonal studies, further show that a subpopulation of the CD133(+) stem-like cell fraction is multipotent and capable of differentiation along tumour and endothelial lineages, possibly via an intermediate CD133(+)/CD144(+) progenitor cell. The findings are supported by genetic studies of specific exons selected from The Cancer Genome Atlas, quantitative FISH and comparative genomic hybridization data that demonstrate identical genomic profiles in the CD133(+) tumour cells, their endothelial progenitor derivatives and mature endothelium. Exposure to the clinical anti-angiogenesis agent bevacizumab or to a γ-secretase inhibitor as well as knockdown shRNA studies demonstrate that blocking VEGF or silencing VEGFR2 inhibits the maturation of tumour endothelial progenitors into endothelium but not the differentiation of CD133(+) cells into endothelial progenitors, whereas γ-secretase inhibition or NOTCH1 silencing blocks the transition into endothelial progenitors. These data may provide new perspectives on the mechanisms of failure of anti-angiogenesis inhibitors currently in use. The lineage plasticity and capacity to generate tumour vasculature of the putative cancer stem cells within glioblastoma are novel findings that provide new insight into the biology of gliomas and the definition of cancer stemness, as well as the mechanisms of tumour neo-angiogenesis.     

怎样上好大学物理习题课

大学物理习题课是物理教学的重要环节。根据作者的教学实践 ,总结了上好习题课的几点经验。写好提纲 ;正确选题 ;精心备课组织课堂教学。实践证明 ,做好了上面几项工作 ,就能在同学配合下上好习题课 ,收到很好的教学效果。     

公共治理理念:公共危机管理的关键因素

公共危机频发的根源在于公共治理的理念缺陷．政府应始终以维护公共利益为宗旨来治理危机,这是消除或减少公共危机之根本。政府功能和责任的有限性,决定了政府不应该、也不能够承担危机的全部责任,必须同时积极寻求社会的参与和合作。社会公众和新闻媒体是公共危机管理中的决定性力量,因此政府应信任并依靠公众和民间组织,善用媒体,组织所有资源和力量,共度危机。