Stable regularities without governing laws?

Can stable regularities be explained without appealing to governing laws or any other modal notion? In this paper, I consider what I will call a ‘Humean system’—a generic dynamical system without guiding laws—and assess whether it could display stable regularities. First, I present what can be interpreted as an account of the rise of stable regularities, following from Strevens (2003), which has been applied to explain the patterns of complex systems (such as those from meteorology and statistical mechanics). Second, since this account presupposes that the underlying dynamics displays deterministic chaos, I assess whether it can be adapted to cases where the underlying dynamics is not chaotic but truly random—that is, cases where there is no dynamics guiding the time evolution of the system. If this is so, the resulting stable, apparently non-accidental regularities are the fruit of what can be called statistical necessity rather than of a primitive physical necessity.     

The molecular epidemiology of parasites

Summary The explosion of new techniques, made available by the rapid advance in molecular biology, has provided a battery of novel approaches and technology which can be applied to more practical issues such as the epidemiology of parasites. In this review, we discuss the ways in which this new field of molecular epidemiology has contributed to and corroborated our existing knowledge of parasite epidemiology. Similar epidemiological questions can be asked about many different types of parasites and, using detailed examples such as the African trypanosomes and theLeishmania parasites, we discuss the techniques and the methodologies that have been or could be employed to solve many of these epidemiological problems.     

Structures and strategies in ancient Greek and Roman technical writing: An Introduction

Most of our knowledge of Greek and Roman scientific practice and its place in ancient culture is derived from our study of ancient texts. In the last few decades, this written evidence—ancient technical or specialist literature—has begun to be studied using tools of literary analysis to help answer questions about, for instance, how these works were composed, their authors’ intentions and the expectations of their readers.This introduction to Structures and strategies in ancient Greek and Roman technical writing provides an overview of recent scholarship in the area, and the difficulty in pinning down what ‘technical/specialist literature’ might mean in an ancient context, since Greek and Roman authors communicated scientific knowledge using a wide variety of styles and forms of text (e.g. poetry, dialogues, letters).An outline of the three sections is provided: Form as a mirror of method, in which Sabine Föllinger and Alexander Mueller explore ways in which the structures of texts by Aristotle and Plutarch may reflect methodological concerns; Authors and their implied readers, with contributions by Oliver Stoll, David Creese, Boris Dunsch and Paula Olmos, which examines what ancient texts can tell us about the place of technical knowledge in antiquity; Science and the uses of poetry, with articles by Jochen Althoff, Michael Coxhead and Laurence Totelin, and a new English translation of the Aetna poem by Harry Hine, which explores the (to us) unexpected roles of poetry in ancient scientific culture.     

The molecular epidemiology of parasites.

The explosion of new techniques, made available by the rapid advance in molecular biology, has provided a battery of novel approaches and technology which can be applied to more practical issues such as the epidemiology of parasites. In this review, we discuss the ways in which this new field of molecular epidemiology has contributed to and corroborated our existing knowledge of parasite epidemiology. Similar epidemiological questions can be asked about many different types of parasites and, using detailed examples such as the African trypanosomes and the Leishmania parasites, we discuss the techniques and the methodologies that have been or could be employed to solve many of these epidemiological problems.     

Mechanisms,the interventionist theory,and the ability to use causal relationships

In the area of social science, in particular, although we have developed methods for reliably discovering the existence of causal relationships, we are not very good at using these to design effective social policy. Cartwright argues that in order to improve our ability to use causal relationships, it is essential to develop a theory of causation that makes explicit the connections between the nature of causation, our best methods for discovering causal relationships, and the uses to which these are put. I argue that Woodward's interventionist theory of causation is uniquely suited to meet Cartwright's challenge. More specifically, interventionist mechanisms can provide the bridge from ‘hunting causes’ to ‘using them’, if interventionists (i) tell us more about the nature of these mechanisms, and (ii) endorse the claim that it is these mechanisms—or whatever constitutes them—that make causal claims true. I illustrate how having an understanding of interventionist mechanisms can allow us to put causal knowledge to use via a detailed example from organic chemistry.     

Can patents prohibit research? On the social epistemology of patenting and licensing in science

A topic of growing importance within philosophy of science is the epistemic implications of the organization of research. This paper identifies a promising approach to social epistemology—nonideal systems design—and uses it to examine one important aspect of the organization of research, namely the system of patenting and licensing and its role in structuring the production and dissemination of knowledge. The primary justification of patenting in science and technology is consequentialist in nature. Patenting should incentivize research and thereby promote the development of knowledge, which in turn facilitates social progress. Some have disputed this argument, maintaining that patenting actually inhibits knowledge production. In this paper, I make a stronger argument; in some areas of research in the US—in particular, research on GM seeds—patents and patent licenses can be, and are in fact being, used to prohibit some research. I discuss three potential solutions to this problem: voluntary agreements, eliminating patents, and a research exemption. I argue against eliminating patents, and I show that while voluntary agreements and a research exemption could be helpful, they do not sufficiently address the problems of access that are discussed here. More extensive changes in the organization of research are necessary.     

Knowledge transfer in theoretical ecology: Implications for incommensurability,voluntarism, and pluralism

Well-known epistemologies of science have implications for how best to understand knowledge transfer (KT). Yet, to date, no serious attempt has been made to explicate these particular implications. This paper infers views about KT from two popular epistemologies; what we characterize as incommensurabilitist views (after Devitt, 2001; Bird, 2002, 2008; Sankey and Hoyningen-Huene 2013) and voluntarist views (after Van Fraassen, 1984; Dupré, 2001; Chakravartty, 2015). We argue views of the former sort define the methodological, ontological, and social conditions under which research operates within ‘different worlds’ (to use Kuhn's expression), and entail that genuine KTs under those conditions should be difficult or even impossible. By contrast, more liberal voluntarist views recognize epistemological processes that allow for transfers across different sciences even under such conditions. After outlining these antithetical positions, we identify two kinds of KTs present in well-known episodes in the history of ecology—specifically, successful model transfers from chemical kinetics and thermodynamics into areas of ecological research—which reveal significant limitations of incommensurabilitist views. We conclude by discussing how the selected examples support a pluralistic voluntarism regarding KT.     

Structure and dynamics of rotary V<Subscript>1</Subscript> motor

Rotary ATPases are unique rotary molecular motors that function as energy conversion machines. Among all known rotary ATPases, F₁-ATPase is the best characterized rotary molecular motor. There are many high-resolution crystal structures and the rotation dynamics have been investigated in detail by extensive single-molecule studies. In contrast, knowledge on the structure and rotation dynamics of V₁-ATPase, another rotary ATPase, has been limited. However, recent high-resolution structural studies and single-molecule studies on V₁-ATPase have provided new insights on how the catalytic sites in this molecular motor change its conformation during rotation driven by ATP hydrolysis. In this review, we summarize recent information on the structural features and rotary dynamics of V₁-ATPase revealed from structural and single-molecule approaches and discuss the possible chemomechanical coupling scheme of V₁-ATPase with a focus on differences between rotary molecular motors.     

Microbes,mathematics, and models

Microbial model systems have a long history of fruitful use in fields that include evolution and ecology. In order to develop further insight into modelling practice, we examine how the competitive exclusion and coexistence of competing species have been modelled mathematically and materially over the course of a long research history. In particular, we investigate how microbial models of these dynamics interact with mathematical or computational models of the same phenomena. Our cases illuminate the ways in which microbial systems and equations work as models, and what happens when they generate inconsistent findings about shared targets. We reveal an iterative strategy of comparative modelling in different media, and suggest reasons why microbial models have a special degree of epistemic tractability in multimodel inquiry.     

A history of entanglement: Decoherence and the interpretation problem

This paper examines the interweaving of the history of quantum decoherence and the interpretation problem in quantum mechanics through the work of two physicists—H. Dieter Zeh and Wojciech Zurek. In the early 1970s Zeh anticipated many of the important concepts of decoherence, framing it within an Everett-type interpretation. Zeh has since remained committed to this view; however, Zurek, whose papers in the 1980s were crucial in the treatment of the preferred basis problem and the subsequent development of density matrix formalism, has argued that decoherence leads to what he terms the ‘existential interpretation’, compatible with certain aspects of both Everett's relative-state formulation and the Bohr's ‘Copenhagen interpretation’. I argue that these different interpretations can be traced back to the different early approaches to the study of environment-induced decoherence in quantum systems, evident in the early work of Zeh and Zurek. I also show how Zurek's work has contributed to the tendency to see decoherence as contributing to a ‘new orthodoxy’ or a reconstruction of the original Copenhagen interpretation.     

Incredulity towards Lyotard: a critique of a postmodernist account of science and knowledge

Philosophers of science have paid little attention, positive or negative, to Lyotard’s book The postmodern condition, even though it has been popular in other fields. We set out some of the reasons for this neglect. Lyotard thought that sciences could be justified by non-scientific narratives (a position he later abandoned). We show why this is unacceptable, and why many of Lyotard’s characterisations of science are either implausible or are narrowly positivist. One of Lyotard’s themes is that the nature of knowledge has changed and thereby so has society itself. However much of what Lyotard says muddles epistemological matters about the definition of ‘knowledge’ with sociological claims about how information circulates in modern society. We distinguish two kinds of legitimation of science: epistemic and socio-political. In proclaiming ‘incredulity towards metanarratives’ Lyotard has nothing to say about how epistemic and methodological principles are to be justified (legitimated). He also gives a bad argument as to why there can be no epistemic legitimation, which is based on an act/content confusion, and a confusion between making an agreement and the content of what is agreed to. As for socio-political legitimation, Lyotard’s discussion remains at the abstract level of science as a whole rather than at the level of the particular applications of sciences. Moreover his positive points can be accepted without taking on board any of his postmodernist account of science. Finally we argue that Lyotard’s account of paralogy, which is meant to provide a ‘postmodern’ style of justification, is a failure.     

国外支持农业科技创新的制度保障与启示

农业科技创新既包括对农业未知领域扣新科学方法与知识的探索,也包括对农业新技术的研发与推广,在这一过程中需要建立一个有效的农业科技创新体系作为支撑。由于农业在一国的经济中往往处于十分重要的基础性地位,因此,在建设与完善农业科技创新体系的过程中,需要政府从法律、宏观科技管理、科研体系设置和科技成果推广体系等方面均拥有十分有力的制度保障。本文对国外支持农业创新的制度保障进行了系统的分析与总结,并在此基础上,针对目前我国农业科技创新的现状,从立法、科技管理和成果推广三个方面提供了一些政策建议。     

Pluto and the platypus: An odd ball and an odd duck - On classificatory norms

Many astronomers seem to believe that we have discovered that Pluto is not a planet. I contest this assessment. Recent discoveries of trans-Neptunian Pluto-sized objects do not militate for Pluto's expulsion from the planets unless we have prior reason for not simply counting these newly-discovered objects among the planets. I argue that this classificatory controversy — which I compare to the controversy about the classification of the platypus — illustrates how our classificatory practices are laden with normative commitments of a distinctive kind. I conclude with a discussion of the relevance of such “norm-ladenness” to other controversies in the metaphysics of classification, such as the monism/pluralism debate.     

An algebraic approach to physical fields

According to the algebraic approach to spacetime, a thoroughgoing dynamicism, physical fields exist without an underlying manifold. This view is usually implemented by postulating an algebraic structure (e.g., commutative ring) of scalar-valued functions, which can be interpreted as representing a scalar field, and deriving other structures from it. In this work, we point out that this leads to the unjustified primacy of an undetermined scalar field. Instead, we propose to consider algebraic structures in which all (and only) physical fields are primitive. We explain how the theory of natural operations in differential geometry—the modern formalism behind classifying diffeomorphism-invariant constructions—can be used to obtain concrete implementations of this idea for any given collection of fields. For concrete examples, we illustrate how our approach applies to a number of particular physical fields, including electrodynamics coupled to a Weyl spinor.     

BVAR as a category management tool: An illustration and comparison with alternative techniques

Category management—a relatively new function in marketing—involves large-scale, real-time forecasting of multiple data series in complex environments. In this paper, we illustrate how Bayesian Vector Auto regression (BVAR) fulfils the category manager's decision-support requirements by providing accurate forecasts of a category's state variables (prices, volumes and advertising levels), incorporating management interventions (merchandising events such as end-aisle displays), and revealing competitive dynamics through impulse response analyses. Using 124 weeks of point-of-sale scanner data comprising 31 variables for four brands, we compare the out-of-sample forecasts from BVAR to forecasts from exponential smoothing, univariate and multivariate Box-Jenkins transfer function analyses, and multivariate ARMA models. Theil U's indicate that BVAR forecasts are superior to those from alternate approaches. In large-scale forecasting applications, BVAR's ease of identification and parsimonious use of degrees of freedom are particularly valuable.     

The mechanism of bursting phenomena in Belousov-Zhabotinsky (BZ) chemical reaction with multiple time scales

The dynamics of a typical Belousov-Zhabotinsky (BZ) reaction with multiple time scales is investigated in this paper. Different forms of periodic bursting phenomena, and specially, three types of chaotic bursters with different structures can be obtained, which are in common with the behaviors observed in experiments. The bifurcations connecting the quiescent state and the repetitive spikes are presented to account for the occurrence of the NK oscillations as well as the different forms of chaotic bursters....     

The mutual influence of aircraft aerodynamics and ship hydrodynamics in theory and experiment

As early as 1784, sharp-eyed engineers and scientists noted striking similarities between the dynamics of seagoing vessels and aerial vehicles. By the early twentieth century, naval engineers and scientists were developing and designing airplanes and dirigibles using empirical principles derived from naval architecture. Several key researchers in aerodynamics began their career as naval architects (David A. Taylor, William F. Durand and Jerome C. Hunsaker) and carried out their experiments in ship testing facilities. By the 1930s, however, the transfer of knowledge was irrevocably reversed as empiricism gave way to more fundamental, physics-based research. The rapid evolution of complex aircraft systems and flight envelopes led to new theoretical developments in aerodynamics and maneuvering, which quickly found their way into naval ship design. The theoretical and experimental results for airfoils, rigid airships and fixed-wing aircraft developed by Ludwig Prandtl, Theodore von Kármán, Max M. Munk and Hilda M. Lyon were employed in the hydrodynamic development of surface ships and submarines. This paper examines how the ideas, concepts and data from one discipline influenced the other and explores the processes by which that knowledge was transferred between disciplines.     

Crustacean neuropeptides

Crustaceans have long been used for peptide research. For example, the process of neurosecretion was first formally demonstrated in the crustacean X-organ–sinus gland system, and the first fully characterized invertebrate neuropeptide was from a shrimp. Moreover, the crustacean stomatogastric and cardiac nervous systems have long served as models for understanding the general principles governing neural circuit functioning, including modulation by peptides. Here, we review the basic biology of crustacean neuropeptides, discuss methodologies currently driving their discovery, provide an overview of the known families, and summarize recent data on their control of physiology and behavior.