The synthesis of toxicarol isoflavone

Zusammenfassung Die Synthese von Toxicarol Isoflavon (2, 2-Dimethylpyrano(6, 5: 7,8)-5-hydroxy-2,4 5-trimethoxyisoflavon) aus 2,2-dimethyl-5-hydroxy-7-methoxychroman wird beschrieben.     

Cytogénétique desLeggada: (1) La formule chromosomique deMus (Leggada)bufo Th., (2) Nouvelles données sur la délétion portant sur le bras court d'unX chezMus (Leggada)triton Th

Summary The author treats 2 topics connected with his studies on the cytogenetics of the African pigmy-mice. (1)Mus (Leggada) bufo Th. shows the primitive complement already detected in other species or subspecies (minutoides ssp ₁,indutus, tenellus, setulosus): 2N=36,N.F.=36, sex chromosomesPR. (2) The deletion of the short arm of oneX-chromosome (X _dc ) was previously observed as heterozygous mutation by 4 in a sample of 7 and 5 . A more important sample (18 , 21 ) gives the following results: 11 X-X, 10 X-X _dc , 18 X-Y. The occurrence of X _dc -X _dc and of X _dc -Y is also very improbable. It is not easy to understand how the chromosomeX _dc may persist in the population if the complementsX _dc -X _dc andX _dc -Y are lethal, which seems to result from these observations.     

Chromosomes and giemsa-bands of the Idaho spotted ground squirrel,Spermophilus brunneus (Howell)

-Spermophilus brunneus . , 13 18 ,S. brunneus S. townsendii mollis (2n=38) , , ; ;S. brunneus . S. brunneus , Spermophilus.

---

---

Supported by National Science Foundation Grants No. GB32114X and No. GB 29131X, and the Sprague Foundation. We thankD. Pozin for technical assistance.     

Potential juvenile hormone analogues containing piperidine ring: Synthesis and biological assay on insects

Summary Some compounds containing piperidine rings have been synthesized, and submitted to biological tests on insects for their hormonal activity on pupae ofTenebrio molitor L. andBombyx mori L. Some of them display a hormoneanalogue or toxic activity.The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. — Per le brevi comunicazioni è responsabile solo l'autore. — . — Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves.This research has been supported by the Italian National Research Council (CNR) special ad hoc program Fitofarmaci e Fitoregolatori, Subproject. 7.Acknowledgments. We thank Prof. G. Jommi for helpful discussions related to this and previous articles on the same subject.     

Chromosomes and some issues of the evolution of the ground squirrel genusCitellus (Rodentia: Sciuridae)

Citellus (s. str.) relictus, C. dauricus C. pygmaeus (2=36, NF=72). . (Colobotis) erythrogenys . fulvus -. . (Urocitellus) undulatus (2n=32, NF=64) . columbianus. Citellus, , Citellus, . , .     

G-band patterns as chromosomal markers,and the interpretation of chromosomal evolution in wild sheep (Ovis)

- . Ovis musimon (2n=54) O. orientalis (2n=54) - - -O. canadensis mexicana (2n=54) O. musimon x O. canadensis ₁₂ - . ₂ 27 . - .

---

---

Supported by National Science Foundation Grant no. GB 32114X and the Sprague Foundation. We thank Dr. T. C. Hsu for assistance in making the chromosome preparations and for advice and encouragement. The Trustees of the Rachelwood Wildlife Research Preserve generously allowed the biopsy of specimens of their custody. Mr.Arthur Popham kindly provided the specimens from Iran while Dr.R. M. Robinson obtained biopsies from the desert sheep.     

DNA synthesis and mitoses in atrial myocytes of rats with aortal stenosis

, . 2- , 1,60 ±0,59% , 0,96 ± 0,44% — . ë . , ³- .     

Artificial lung ventilation during diaphragmatic paralysis

ÿe , CO₂ . CO₂ ÿe . , ÿe , .     

Separation of rat liver mitochondrial amine oxidases

.     

Proteins of venezuelan equine encephalomyelitis virions

. : (. . 59,000–61,000 ), (34,000–38,000) (15,000–18,000).     

The effect of chloramphenicol analogs on protein biosynthesis in a cell-freeEscherichia coli B system

a aaa a aa aa a a E. coli aa, a aa aa a , a a aa - a .

---

---

Laboratory of Biological Investigations.

---

Laboratory for Chemistry of Antibiotics.     

Interaction of 1-anilino-8-naphthalene sulfonate with yeast glyceraldehyde-3-phosphate dehydrogenase

1--8- () -3- () . []:[]<10:1 140 000 3±1 5×10^–5 . , i 5×10^–5 –6×10^–5 M. , .     

Cardenolide glycosides from the adults and eggs ofChrysolina fuliginosa (Coleoptera: Chrysomelidae)

Besides the known sarmentogenin 3-O--D-allopyranoside (1) and digitoxigenin-3-O-[-D-xylopyranosyl-(14)-2, 3-di-O-acetyl--D-allopyranoside] (4), four new cardiac glycosides (2, 3, 5 and6) have been isolated from the defensive glands of adults ofChrysolina fuliginosa. The structures of the new compounds were determined by¹H NMR at 600 MHz and FABMS. Compounds1–6, present in the adults ofC. fuliginosa, have also been identified in the eggs.     

X-ray research of polycrystals. X-ray diffraction methods for precision determinations of polycrystal lattice parameters over unsolved double lines

. - .     

The peculiarities of capacitance vessel reflex responses

Conclusion Changes of the vessel capacity resulted from the pressor synocarotid reflexes, intestinal chemoreflexes and reflexes from the right atrium or ventricle and electric stimulation of the somatic nerve afferents can be either similarly or differently directed as compared with the responses of the resistance vessels.

---

, , , .

     

Effect of dipyridamole on glomerular mesangial cell ecto-5′-nucleotidase expression

Although dipyridamole has been extensively studied as an anti-aggregating agent, its mechanism of action has not been elucidated. Cultured mesangial cells were treated with dipyridamole 1–100 M from 6–72 h. Ecto-5-nucleotidase activity approximately doubled (from 115±11 to 226±14 nmol/min/mg) after treatment with 100 M dipyridamole for 72 h. This effect was concentration- and time-dependent. Cycloheximide, an inhibitor of protein synthesis, did not alter basal 5-nucleotidase activity. However, it prevented stimulation by 5 M dipyridamole. Adenosine availability at the receptor sites was increased by dipyridamole and S-(p-nitrobenzyl)-6-thioinosine (NBTI), which inhibit adenosine uptake into the cell. Addition of dipyridamole or NBTI to the adenosine-treated mesagial cells produced an additive increase in ecto-5-nucleotidase activity. Dipyridamole, through its effect on extracellular adenosine and ecto-5-nucleotidase, may have an influence upon regulation of the glomerular microcirculation.     

Some functional characteristics of the electroreceptors (the ampullae of lorenzini) of elasmobranchs

. . , ( I) , ( )- .     

Extrapyramidal pathways with monosynaptic effects upon primate α-motoneurons

, , , , , -.     

Normalization by nucleotides of impairments in deamination of nitrogenous compounds in liver of tumor-bearing mice

-2 (3)--3- - .