Eine neue Serie wenig toxischer Lokalanästhetika aus der Xylocain-Reihe

Summary Local anaesthetics of low toxicity were developed from the group of aroxy- and aralkoxysubstituted diethylaminoacetanilides. The substances were tested for local anaesthetic activity in surface and infiltration anaesthesia and for toxicity.     

Ein neuer vorteilhafter Substitutionstypus der Lokalanästhetika

Summary Highly active and relatively little toxic local anaesthetics from the group of aroxy- and aralkoxycarbanilic acids were developed. The substances were tested for local anaesthetic activity in surface and infiltration anaesthesia.     

Eine neue Reihe lokalanästhetisch wirksamer basischer Acetylmesidine

Summary Highly active, and relatively little toxic, local anesthetics were developed from the group of substituted acetylmesidines. The substances were tested for toxicity and local anesthetic activity in surface and infiltration anesthesia.     

Eine Absorptionsschicht der hohen Atmosphäre?

Summary The varying intensity of the shortest wave-length 2863 Å of the solar spectrum points to the possibility that labile absorption spectra exist in the higher atmosphere. As spectrographs mounted on V-2 rockets have showen that at a height of 55 km an absorption exists around 2800 Å besides the strong Frauenhofer-lines, and as the termination of the solar spectrum at 2400 Å appears remarkably abrupt, we may suspect a new absorption in the high atmosphere, for which possibly the oxides of nitrogen, primarily the NO ₂ ⁺ or the NO⁺ ion, are responsible.     

Versuche auf dem Gebiet der Lokalanästhesie mit protrahierter Wirkung. III

Summary The addition of simple quaternary salts (as I and II) to solutions of local anaesthetics, effects a pronounced prolongation of the time of complete infiltration anaesthesia. These salts have no effect on the time of surface anaesthesia. Other pharmacological characteristics of these mixtures were also determined.     

Eine Näherungsformel für die Prämie der Invalidenversicherung

Summary Formulæ for the approximate evaluation of premiums for a disability pension payable continually.     

Eine methode zur analyse und quantitativen auswertung biologischer steady-state-Übergänge

Summary Using an electronic analog model, it was possible to analyse steady state transitions of energy fluxes during temperature adaption, accomodation and other responses of biological open systems. This model reproduced and quantitatively calculated expected responses on the basic of transport equations derived from irreversible thermodynamics. It was found that this model could account for certain observed biological effects.     

Eine einfache analytische Methode zur Bestimmung des Verhältnisses von Mutter- und Tochtersubstanz in radioaktiven Präparaten

Summary A simple and time saving numerical method is described permitting the rapid determination of mother to daughter ratios in biological specimens containing radionuclides.     

Über eine neue Färbemethode von Bakterienkulturen zum Zweck rascher Feststellung der Wirkung bakterizider Agenzien

Summary A method of staining bacterial colonies with the new N.N.C.D. reagent is described that has been used in the course of a research work on the influence of soft X-rays and slow cathode rays on microbes.     

Über neue chemotherapeutisch wirksame Sulfonamide

Summary Some new 2- and 4-sulfanilamido-5-alkoxy-pirimidines and their hydroxy-, methoxy-, methylmercapto-and methyl-derivatives were prepared. All of the substances described were tested on white mice infected withStreptococcus pyogenes.     

Glucoacetyldigoxosid und Glucodigoxosid,neue genuine Glykoside aus den Blättern vonDigitalis schischkinii (Ivan.) Werner

Summary A new cardiotonic pentaglycoside with the structure glucoacetyldigoxoside (digoxigenin--D-glucosido-acetyltetradigitoxoside) was isolated from the leaves ofDigitalis schischkinii (Ivan.) Werner. Its desacetyl product, glucodigoxoside has also been found in the fraction of most polar glycosides.

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Wir danken Herrn Dr. F. Kaiser, Mannheim, für die Überlassung einer Probe von Digoxosid und Herrn Prof. Dr. H. Wagner, München, für die Durchführung der Elementaranalysen und optischer Drehungen.     

Über eine neue Herstellung aromatisch substituierter Reduktone

Summary Equimolecular amounts of an aromatic or hetero-cyclic aldehyde, glyoxal and cyanideion combine in slightly alkaline aqueous solution to give 4-aryl-2-hydroxytetronimides (I). These are cyclic reductones comparable to imino-ascorbic acid. Oxidation yields dehydro compounds (III) (4-aryl-2, 3-dioxo-4-hydroxy-butyric acid lactones); hydrolysis gives 4-aryl-2-hydroxy-tetronic acids (V) which are easily decarboxylated to -aryl-lactic acids (VII). On hydrogenation, the compounds I are converted to -aryl-, -dihydroxy-butyramides.     

Eine Produktdarstellung für das Deckungskapital

Summary The author derives from the differential equation for the annuity and from the difference equation for the value of the policy several relations, which allow to represent approximately the value of composed forms of insurances by the value of simple forms of insurances; likewise, it is easy to render formally the influence of a variation of the rate of interest.     

Über die Oxydation ungesättigter Fettsäuren durch Pflanzensäfte

Summary Extracts from various parts, including root nodules, of different leguminous plants, and extracts from leaves of several other plants (belonging toSolanaceae andLabiatae) are able to accelerate efficiently the oxidation of unsaturated fatty acids.     

Strukturabhängigkeit der Wirkung muscarinähnlicher Verbindungen

Summary Relations between structure and biological activity of some new analogues of muscarine are demonstrated. From the results a theory of cholinergic action and the structure of active acetylcholine, as well as the cholinergic receptor, may be developed.     

DNP-Aminosäuren

Ohne Zusammenfassung     

Kälteeinfluss und Peptidase-Aktivität von Bakterien

Summary The effect of freezing on the peptidase activities of some bacteria and their cell-free enzyme preparations has been studied. Significant differences were found in the activity of peptidase and in their temperature coefficient.