Coplanare Hetero-oligobasen (Phthalanilide), hochaktive Cytostatica

Summary Coplanar hetero-oligobases (phthalanilides), highly effective cytostatica. Bacteriometrical and physico- chemical tests on coplanar hetero-oligobases have shown the formation of a complex with DNA to be the cause of the cytostatic effect. For several of these compounds an evident correlation is demonstrated between bacteriostatic efficiency and reaction with DNA.

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Ausgeführt mit Unterstützung durch den Krebsforschungsfonds des Kultusministeriums Nordrhein-Westfalen.     

Chromosomes of three Asian mammals:Meriones meridianus (Rodentia: Gerbillinae),Spermophilopsis leptodactylus (Rodentia: Sciuridae),Ochotona rufescens (Lagomorpha: Ochotonidae)

Zusammenfassung Chromosomenanalyse von 3 asiatischen Säugetieren:Meriones meridianus (2n=50),Ochotona rufescens (2n=60) undSpermiophilopsis lepto-dactylus (2n=38), Deren 2n's und Karyotypen wurden mit verwandten Formen ninsichtlich der Geschlechter und Gattungen verglichen und zur Klassifizierung diskutiert.     

Tryptophan (Trp), serotonin (5-HT), monoamino oxidase (MAO) and 5-hydroxyindole acetic acid (5-HIAA) in brain and subesophagic ganglions of earthworms. Effects of Parathion

Summary Tryptophan, 5-HT, MAO and 5-HIAA were determined in the first 5 segments of earthworms (Oligochaetae) where the brain and subesophagic ganglions are located. Tranylcypromine (IMAO) decreased MAO activity increasing 5-HT and decreasing 5-HIAA. Motility and survival of worms were disturbed. InAllolobophora species (young worms), parathion fumigation decreased acetylcholinesterase (AChE) activity and increased Trp, 5-HT and 5-HIAA. Motility was diminished after 24 h: it worsened after 72, but returned to normal levels 40/50 days later.Publication of the National Institute of Agrarian Technology (INTA), Argentina.Acknowledgments. We are most grateful to Prof. Zlatko Tomsic (from the Lillo Institute, Tucumán) and to Leticia Alvarado (from INTA) and to Prof. Mirta P. de Matosian for earthworm classification.     

The schizogony of Polychromophilus (Haemoproteidae), cosmopolitan parasite of Microchiroptera]

The schizogony of Polychromophilus was partially known by the findings of Schingarew, Mer and Goldblum who demonstrated microschizonts in the reticulo-endothelial tissue. The present work completes these data by showing the presence of macroschizonts in the lungs of both African and European species. These schizonts are characterized by their large size, the hypertrophy of the host cell and its nucleus and the evolution of the parasite apparently slow when young, becoming rapid later.     

Animal pharmacology of oxapadol (MD 720111), a new non-narcotic analgesic

Summary Oxapadol is a non-narcotic analgesic with an unusual chemical structure. It possesses analgesic activity in 4 species similar to that of other non-narcotic reference analgesics. It also shows antipyretic and antiinflammatory effects and in the analgesic dose range is devoid of undesirable neurological, gastro-intestinal and cardiovascular side-effects.Acknowledgments. We thank Mss M. Mazadier, R. Adam and M. Delhommeau for technical assistance, Dr R.D. Porsolt for help with the text and Ms M. Fiquémont for secretarial assistance.     

Chromosomes of the rock hyrax,Procavia capensis (Pallas), 1767

Zusammenfassung Es werden die Chromosomen eines weiblichen und zwei männlicher Felshyraxarten,Procavia capensis (Pallas), 1767 (Hyracoidea: Mammalia) beschrieben. Ihre diploide Chromosomenzahl ist 2n=54. Mit Ausnahme derX-Chromosomen sind keine eindeutigen Chromosomenkomplement-übereinstimmungen mit denjenigen von Elefanten sichtbar. Hingegen sind die allgemeinen Eigentümlichkeiten der Karyotypen und die Anzahl der Hauptarme der Chromosomen ähnlich und stimmen überdies mit taxonomischen Verbindungen, die zwischen den Hyracoidea und den Proboscidea angenommen werden, überein.     

An anaesthetic forCorophium volutator (pallas) andMarinogammarus obtusatus (dahl), crustacea,amphipoda

Résumé On a trouvé que l'anesthésique M.S. 222 Sandoz est effectif sur les amphipodesCorophium volutator etMarinogammarus obtusatus. Une concentration de 0.5 g/l peut anesthésier les animaux avec un délai de 30 min. Tous les animaux des deux espèces se remettent de l'anesthésie, même après 2 h dans cette concentration.     

Preparation of ‘new’-vasoconstrictine (SVPx), a vasoconstrictor hormone of plasma

Résumé La «nouvelle»-vasoconstrictine (SVPx 1962), une hormone vasoconstrictrice du plasma, a été préparée par distribution à contre-courant en quantité suffisante pour l'étude de sa structure chimique et de ses propriétés biologiques.