Thrombozytose und Eosinopenie bei Ratten nach einmaliger 5-Oxytryptamininjektion

Summary After injection of a high dose of 5-hydroxytryptamine into rats, the blood reveals a strong increase of the blood platelets and a definite decrease of the eosinophiles. The maxima of increase and decrease are in temporal accordance.     

Die teratogene Wirkung von Äthylharnstoff und Nitrit bei Ratten

Summary Simultaneous peroral application of ethylurea and sodium nitrite to pregnant Sprague-Dawley rats, on the 9th and 10th days of gestation, causes embryotoxic and/or teratogenic effects. Each substance alone does not afflict the fetuses, whereas the combined addition to the food permits the formation of ethyl nitroso-urea in the digestive tract. The latter readily passes the placenta and develops the teratogenic effect. It is to be considered that teratogenic substances can occur from food constituents in the human organism also.     

Radiotelemetrische Körpertemperaturmessung bei Mäusen und Ratten

Summary A simple and inexpensive radiotelemetric method for measurement of body temperature of small laboratory animals is described, and an example of a pharmacological application is given.

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Mit Unterstützung durch einen Kredit vom Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung.     

Dämpfung des Kältezitterns durch Pentobarbital und Pethidin bei Ratten

Summary In rats, shivering was induced by cooling. Shivering started at 36.6°C in unanaesthetized rats and at 36.0°C in animals with light pentobarbital anaesthesia (5 mg/kg i.V.). Pethidine (2 mg/kg) lowered the onset of shivering in unanaesthetized rats to 35.3 °C and in anaesthetized animals to 33.0°C. The results suggest that the effect of pethidine upon shivering is potentiated by pentobarbital.     

Die Mitosehäufigkeit in der normalen Epidermis der Maus nach einmaliger DMSO-Einwirkung

Summary 12 h after local application of DMSO on the epidermis of the mouse, increased mitotic activity has been observed, the maximum occurring 24 h after the onset of the experiment. Subsequently a distinct reduction of the frequency of mitosis can be seen with a minimum occurring about 53 h after the beginning of experiment. The initial mean value is reached 12 h after.     

Totale Plasmaclearance von Na[51Cr-ÄDTA] und Inulin-14C bei Ratten

Summary Plasmaclearance and whole body retention of Na[⁵¹Cr-EDTA) and of inulin-¹⁴C have been determined in healthy rats. The total plasmaclearance of both compounds is identical and corresponds to the value of glomerular filtration rate in rats as determined under steady-state conditions.     

Ursachen der geschlechtsunterschiedlichen MilchdrÜsengewebsentwickiung bei Ratten

Summary Under the same hormonal conditions, mammary gland growth in adult female rats is more pronounced than in males. Since there are no differences in the glandular development of both sexes, either at birth or at 30 days of life, it is assumed that male rats react less sensitively than female rats in response to a hormonal stimulus with regard to mammary gland growth. It is presumed that androgen influence during the differentiation stage is responsible for the fixation of a decreased sensitivity of the positive feedback-mechanism between estrogens and prolactin secretion in males. Thus changes in sensitivity would be the reason for mammary gland growth in males being smaller than in females under the same hormonal conditions.

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Dieser Arbeit liegen zum Teil die Untersuchungsergebnisse einer SchÜler-Facharbeit von U.Rieser zugrunde.     

Die Wirkung von intraventrikulär applizierteml-Glutamat auf die Akquisition und Extinktion einer instrumentellen Konditionierungsreaktion bei Ratten

Summary The effect of intraventriculary administeredl-glutamic acid upon a conditioned avoidance response was studied. The amino acid caused at first shorted reaction times and increased success quota, and later prolonged the reaction times and slowed success quota.     

Hemmwirkung von Cysteamin auf den Corticosterongehalt der Nebennieren von Ratten nach Stress-Einwirkung

Summary In rats, cysteamine has an inhibiting effect on the corticosterone increase in the adrenals and blood following stress. It is discussed whether cysteamine might interfere with the corticosteroide synthesis.     

Das Nebenhodengangepithel der Ratte nach Hypophysektomie und nach Androgensubstitution

Summary The epithelium of the epididymal duct (corpus region) of the rat after hypophysectomy and after androgen substitution has been examined by light and electron microscopy. The epithelium consists of 3 different cell types: principal, accessory (Nebenzellen), and basal cells. The characteristics of these cells disappear after hypophysectomy and redifferentiate after androgen application. The alterations of the principal and accessory cells in course of time (from the 1st week up to 9 weeks after injection of 20 mg testosterone propionate) are the subject of this report.     

Der Einfluss der Epiphyse auf die Lokomotionsaktivität bei Ratten

Summary After pinealectomy adult hypoactive rats show an increased exploratory behavior, whereas adult hyperactive rats show no significant behavioral change. These data are discussed in relation to brain serotonin content.

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Durchgeführt im Rahmen des DFG-Schwerpunktprogrammes Neuroendokrinologie (Vo 135/4).

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Frau Dr. D. Freund, Mainz, danke ich für die Erlaubnis zur Benutzung der Open-Field Anlage, Frau H. Untiedt für technische Hilfe bei der Pinealektomie.     

Morphologische Veränderungen der Extraorbitaldrüsen weisser Ratten nach Kupfermangelernährung

Summary Copper deficiency of the rat leads to a reduction of the histochemically demonstrable cytochrome oxidase activity of the glandula extraorbitalis, and to atrophy and fatty degeneration of the glandular cells. The histological alterations are more pronounced in the male than in the female.     

Fluoreszenzmikroskopische Untersuchungen am Hypothalamus männlicher Ratten nach Behandlung mit einer antimaskulin wirkenden Substanz

Summary In new-born male rats daily injections of a strong antiandrogenic substance led to an increase of the catecholamine content in the parvicellular perikarya as well as in nerve fibres leading to the paraventricular and supraoptic nuclei. The same effect was observed in male rats castrated immediately after birth. A possible relationship between gonadotropic releasing factors and the catecholamin content of the hypothalamic nuclei is discussed.     

Hemmung des durch blutdrucksenkende Pharmaka bei Ratten ausgelösten Trinkens durch Nephrektomie

Summary The drinking response of rats seen after the hypotensive drugs phentolamine, isoproterenol and hydralazine/bretylium can be abolished by nephrectomy. It is postulated, that the dipsogenic activity of these drugs is mediated by renin.     

Die Azetylcholinesterase an der motorischen Endplatte des Rattenzwerchfells nach Intoxikation mit Paraoxon und Soman bei Applikation von Oximen

Summary The inhibition of AChE by Paraoxon is overcome by the application of the oximes 2-PAM, Toxogonin^® and HS 3. Soman inhibited AChE is affected only to a limited extent by HS 3 and HS 9.     

Der Kininogenspiegel von Ratten und Kaninchen während der Gestation

Summary The investigations concern the alterations of the plasma kininogen level of rats and rabbits during gestation. The results obtained with these animals are analogous to man. For this reason rats and rabbits are suitable models for further studies on the importance of the kininogen/kinin-system during pregnancy and delivery.     

Die Degenerationsraten präimplantierter Eier von Vitamin A-hyper- und avitaminotischen Ratten

Summary Comparing pre-implanted rat ova of animals suffering from Vitamin A deficiency or overdosage with normal ones, it was found that the amount of degenerated eggs was significantly higher in both the treated groups than in normal untreated animals. The mitotic stages of the segmentation steps prove to be highly sensitive to previous changes in the interior and exterior environment of the egg.     

Lipoide und Virulenz bei Typhusbakterien

Summary Researches on lipids from various strains of theSalmonella group showed that in the content of neutral lipids there is no difference between virulent and not virulent strains. Virulent strains contain by far less phosphatides than not virulent or weakly virulent strains.     

Aktivität der Aldolase und der Succinatdehydrogenase (SDH) in der weissen und roten Skelettmuskulatur junger und alter Ratten

Summary The activity of aldolase and succinatdehydrogenase (SDH) in white and red skeletal muscle of young (3–7 months) and old (20–30 months) rats has been determined. In addition also the SDH of liver was measured. The activity of aldolase is higher in white than in red muscles, while SDH shows a higher activity in red than in white muscles. The activity of aldolase is not influenced by ageing in white muscles, but decreased in red muscles by 23%. In old animals the activity of SDH is 34% less in white and 52% less in red muscles. In liver the activity is 44% less. The significance of these changes for the energy metabolism of skeletal muscle is discussed.