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Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh 总被引:22,自引:0,他引:22
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Sex determination. What makes a man a man? 总被引:1,自引:0,他引:1
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Metabolism of 4-14C-ethynyl oestradiol in women 总被引:1,自引:0,他引:1
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Brain myelination after neonatal administration of oestradiol 总被引:4,自引:0,他引:4
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Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones 总被引:14,自引:0,他引:14
Oestrogen, acting in both the brain and pituitary, has a critical role in regulating the reproductive cycle in most mammals. In the brain, oestrogen regulates the release of luteinizing hormone-releasing hormone (LHRH) partly through a mechanism that is blocked by inhibitors of DNA-dependent RNA synthesis or protein synthesis. The distributions of oestrogen-concentrating neurones and of LHRH neurones overlap. The present study was undertaken to determine whether genomic effects of oestrogen mediated by nuclear oestradiol concentration include a direct effect on LHRH-containing neurones. During extensive studies in which the immunocytochemical method for localizing LHRH neurones was optimized and made compatible with the autoradiographic method for detecting oestrogen-concentrating neurones, doubly-labelled cells were very rarely seen. This suggests that genomic regulatory effects of oestrogen which depend on nuclear retention are not exerted directly on most LHRH neurones, but rather must be mediated by another class of neurones. 相似文献
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Biological activity of a polar metabolite of vitamin D 总被引:8,自引:0,他引:8
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The nucleolus, virus infection, and trisomy in man 总被引:6,自引:0,他引:6
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Vitamins, sugars and ethanol metabolism in man 总被引:2,自引:0,他引:2
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