共查询到20条相似文献,搜索用时 15 毫秒
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Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription 总被引:2,自引:0,他引:2
Wang X Arai S Song X Reichart D Du K Pascual G Tempst P Rosenfeld MG Glass CK Kurokawa R 《Nature》2008,454(7200):126-130
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Ferres-Marco D Gutierrez-Garcia I Vallejo DM Bolivar J Gutierrez-Aviño FJ Dominguez M 《Nature》2006,439(7075):430-436
Cancer is both a genetic and an epigenetic disease. Inactivation of tumour-suppressor genes by epigenetic changes is frequently observed in human cancers, particularly as a result of the modifications of histones and DNA methylation. It is therefore important to understand how these damaging changes might come about. By studying tumorigenesis in the Drosophila eye, here we identify two Polycomb group epigenetic silencers, Pipsqueak and Lola, that participate in this process. When coupled with overexpression of Delta, deregulation of the expression of Pipsqueak and Lola induces the formation of metastatic tumours. This phenotype depends on the histone-modifying enzymes Rpd3 (a histone deacetylase), Su(var)3-9 and E(z), as well as on the chromodomain protein Polycomb. Expression of the gene Retinoblastoma-family protein (Rbf) is downregulated in these tumours and, indeed, this downregulation is associated with DNA hypermethylation. Together, these results establish a mechanism that links the Notch-Delta pathway, epigenetic silencing pathways and cell-cycle control in the process of tumorigenesis. 相似文献
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GlcNAcylation of histone H2B facilitates its monoubiquitination 总被引:1,自引:0,他引:1
Fujiki R Hashiba W Sekine H Yokoyama A Chikanishi T Ito S Imai Y Kim J He HH Igarashi K Kanno J Ohtake F Kitagawa H Roeder RG Brown M Kato S 《Nature》2011,480(7378):557-560
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Opposing LSD1 complexes function in developmental gene activation and repression programmes 总被引:4,自引:0,他引:4
Wang J Scully K Zhu X Cai L Zhang J Prefontaine GG Krones A Ohgi KA Zhu P Garcia-Bassets I Liu F Taylor H Lozach J Jayes FL Korach KS Glass CK Fu XD Rosenfeld MG 《Nature》2007,446(7138):882-887
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Global histone acetylation and deacetylation in yeast 总被引:67,自引:0,他引:67
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription 总被引:4,自引:0,他引:4
Metzger E Wissmann M Yin N Müller JM Schneider R Peters AH Günther T Buettner R Schüle R 《Nature》2005,437(7057):436-439
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Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression 总被引:1,自引:0,他引:1
Lan F Collins RE De Cegli R Alpatov R Horton JR Shi X Gozani O Cheng X Shi Y 《Nature》2007,448(7154):718-722
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Varambally S Dhanasekaran SM Zhou M Barrette TR Kumar-Sinha C Sanda MG Ghosh D Pienta KJ Sewalt RG Otte AP Rubin MA Chinnaiyan AM 《Nature》2002,419(6907):624-629