Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation

The t(11;14) (q13;q32) chromosome translocation has been reported in diffuse small and large cell lymphomas and in chronic lymphocytic leukaemia (B-CLL) and multiple myeloma. Because chromosome band 14q32 is involved in this translocation, as well as in the t(8;14) (q24;q32) translocation of the Burkitt tumour, interruption of the immunoglobulin heavy-chain locus was postulated for this rearrangement. We have cloned the chromosomal joinings between chromosomes 11 and 14 and also between chromosomes 14 and 18, in B-cell tumours carrying translocations involving these chromosomes, and suggested the existence of two translocated loci, bcl-1 and bcl-2, normally located on chromosomes 11 (band q13) and 18 (band q21) respectively, involved in the pathogenesis of human B-cell neoplasms. The results indicate that in the leukaemic cells from two different cases of CLL, the breakpoints on chromosome 11 are within 8 nucleotides of each other and on chromosome 14 involve the J4-DNA segment. Because we detected a 7mer-9mer signal-like sequence with a 12-base-long spacer on the normal chromosome 11, close to the breakpoint, we speculate that the t(11;14) chromosome translocation in CLL may be sequence specific and may involve the recombination system for immunoglobulin gene segment (V-D-J) joining.     

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.     

有限夹心半群T(X,Y;θ)的正则性与Green关系

设X,Y是非空集合。记T(X,Y)为X到Y的映射全体构成的集合,θ是Y到X的一个确定的映射,α,β∈T(X,Y),定义运算:αβ=αθβ,这里,αθβ表示一般映射的合成。则T(X,Y)关于运算构成一个半群,称为夹心半群T(X,Y;θ)。当X,Y都为有限集合且|X|>1,|Y|>1时,称夹心半群T(X,Y;θ)为有限夹心半群。讨论了T(X,Y;θ)、T(X;θ)和TX之间的联系,研究了有限夹心半群T(X,Y;θ)的正则性和G reen关系。     

夹心半群TE(X,Y,θ)上的一个同余

对于Y上的任意非平凡等价关系E,讨论了由E确定的夹心半群TE(X,Y,θ)的同余格C(TE(X,Y,θ)),证明了当θ是单射时,C(TE(X,Y,θ))可分解为3个不相交的完全子格[C(δ),Cα(δ)],[C(E),Cα(E)]和[C(ω),Cα(ω)].在此基础上考察了TE(X,Y,θ)上的一个同余τ,并证明了当E为单等价关系时,τ是[C(E),Cα(E)]中的唯一原子.     

关于集族L-S-KKM(X,Y,Z)的GL-SKKM型定理

在较广泛的L-凸空间中借助具转移紧闭值的广义L—S—KKM映象，利用广义L—S—KKM性质，得到了L一凸空间中关于集族L—S—KKM(X，Y，Z)的一组GL—SKKM型定理。推广和改进了许多已知的结果。     

Localization of the X inactivation centre on the human X chromosome in Xq13

X-chromosome inactivation results in the strictly cis-limited inactivation of many but not all genes on one of the two X chromosomes during early development in somatic cells of mammalian females. One feature of virtually all models of X inactivation is the existence of an X-inactivation centre (XIC) required in cis for inactivation to occur. This concept predicts that all structurally abnormal X chromosomes capable of being inactivated have in common a defineable region of the X chromosome. Here we report an analysis of several such rearranged human X chromosomes and define a minimal region of overlap. The results are consistent with models invoking a single XIC and provide a molecular foothold for cloning and analysing the XIC region. One of the markers that defines this region is the XIST gene, which is expressed specifically from inactive, but not active, X chromosomes. The localization of the XIST gene to the XIC region on the human X chromosome implicates XIST in some aspect of X inactivation.     

Yφ(t)-复合非时齐Poisson过程模型结构可靠度

讨论强度为Yφ(t),其中Y为初始随机变量,φ(t)是t的单调递减连续实函数,应力为强度函数λ(t)＝exp (α+βt)(t≥0;α,β为任意实数)的复合非时齐Poisson过程模型结构可靠度,获得应力与强度在各种不同情况下的结构可靠度表达式.     

Parental origin of chromosomes involved in the translocation t(9;22).

Functionally equivalent genetic maternal can be labelled by an epigenetic marking process and used differentially depending on whether its origin is maternal or paternal. This phenomenon is known as genomic imprinting and is manifested at either the chromosomal or gene level. Genomic imprinting seems to play an important role in cancer predisposition syndromes, and phenotypic consequences are evident in constitutional deletion syndromes and uniparental disomies. Moreover, there seems to be a preferential retention of paternal alleles in sporadic tumours such as Wilms' tumour, rhabdomyosarcoma, osteosarcoma and retinoblastoma. To investigate whether chromosomes involved in acquired abnormalities of haematologic neoplasms show a similar 'parent of origin' bias, we studied the inheritance of the translocated chromosomes 9 and 22 in cases of Philadelphia-chromosome-positive leukaemia, using unique specific chromosome band polymorphisms. Here we show that the translocated chromosome 9 was of paternal origin, whereas the translocated chromosomes 22 were derived exclusively from the maternal copy, in 11 cases with reliable polymorphisms. Our data therefore provide evidence that imprinting phenomena may play an important role in acquired tumour-specific chromosome rearrangements.     

核型为46，XYt（1；13）（p22；q12）病例的细胞遗传学分析

本文报道了一例人类１号和１３号染色体易位的病例，经细胞遗传学检查证明，患者的核型为４６，ＸＹｔ（１；１３）（ｐ２２：ｑ１２），此患者临床表型正常，但其爱人先后多次早期流产。此病例经鉴定为国际首报病例。本文对衍生的易位染色体来源、患者染色体核型与表型的关系及生育正常后代的可能性等问题作了分析。     

异质富勒烯[4,6]-C22X2（X=B,N）的密度泛函理论研究

在混合密度泛函B3LYP理论下,用6-31G（d）基函数对同位置取代[4,6]-C24所得的3种衍生物（C22BN,C22B2和C22N2）进行了几何构型优化和频率分析,计算了前线轨道能级差、电离势、电子亲和势、绝对电负性和整体硬度.结果表明,所研究的C22X2（X=B,N）3种衍生物中,C22B2具有最小的电离势I、电子亲和势A和绝对电负性χ,这说明它更容易被氧化和与亲电试剂反应.与全碳分子C24相比,B,N的取代降低了富勒烯分子的稳定性.     

Ipi-t,Ipi-3(t)在水稻中的物理定位及水稻第12染色体的识别

选用与水稻12染色体上Ipi-t,Ipi-3(t)和Pi-4(t)及着丝粒连锁的RFLP标记RZ670对水稻进行了荧光原位杂交。清楚显示了第12染色体着丝粒所在的位置,为水稻染色体的准确识别提供了一种新的方法。     

TE(X)的变种半群TE(X;θ)的若干性质

设X是一个非空集合，E是X上的等价关系，TE(X)={f∈JX2↓A(a，b)∈E，(f(a)，f(b))∈E)．对于半群S中的一个取定元素θ∈S，重新定义S上的运算。为f。g=fθg，其中等式右边表示原来的运算，S关于这个新的运算所成的半群称为S的变种半群．本文讨论了TE(X；θ)的Green关系和Symons同余之间的联系．