共查询到20条相似文献,搜索用时 0 毫秒
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Enzymatic control of cell division in micro-organisms 总被引:1,自引:0,他引:1
NICKERSON WJ 《Nature》1948,162(4111):241-245
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Genetic control of cell size at cell division in yeast. 总被引:41,自引:0,他引:41
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Pascal AA Liu Z Broess K van Oort B van Amerongen H Wang C Horton P Robert B Chang W Ruban A 《Nature》2005,436(7047):134-137
In order to maximize their use of light energy in photosynthesis, plants have molecules that act as light-harvesting antennae, which collect light quanta and deliver them to the reaction centres, where energy conversion into a chemical form takes place. The functioning of the antenna responds to the extreme changes in the intensity of sunlight encountered in nature. In shade, light is efficiently harvested in photosynthesis. However, in full sunlight, much of the energy absorbed is not needed and there are vitally important switches to specific antenna states, which safely dissipate the excess energy as heat. This is essential for plant survival, because it provides protection against the potential photo-damage of the photosynthetic membrane. But whereas the features that establish high photosynthetic efficiency have been highlighted, almost nothing is known about the molecular nature of the dissipative states. Recently, the atomic structure of the major plant light-harvesting antenna protein, LHCII, has been determined by X-ray crystallography. Here we demonstrate that this is the structure of a dissipative state of LHCII. We present a spectroscopic analysis of this crystal form, and identify the specific changes in configuration of its pigment population that give LHCII the intrinsic capability to regulate energy flow. This provides a molecular basis for understanding the control of photosynthetic light-harvesting. 相似文献
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Jaillon O Bouhouche K Gout JF Aury JM Noel B Saudemont B Nowacki M Serrano V Porcel BM Ségurens B Le Mouël A Lepère G Schächter V Bétermier M Cohen J Wincker P Sperling L Duret L Meyer E 《Nature》2008,451(7176):359-362
Most eukaryotic genes are interrupted by non-coding introns that must be accurately removed from pre-messenger RNAs to produce translatable mRNAs. Splicing is guided locally by short conserved sequences, but genes typically contain many potential splice sites, and the mechanisms specifying the correct sites remain poorly understood. In most organisms, short introns recognized by the intron definition mechanism cannot be efficiently predicted solely on the basis of sequence motifs. In multicellular eukaryotes, long introns are recognized through exon definition and most genes produce multiple mRNA variants through alternative splicing. The nonsense-mediated mRNA decay (NMD) pathway may further shape the observed sets of variants by selectively degrading those containing premature termination codons, which are frequently produced in mammals. Here we show that the tiny introns of the ciliate Paramecium tetraurelia are under strong selective pressure to cause premature termination of mRNA translation in the event of intron retention, and that the same bias is observed among the short introns of plants, fungi and animals. By knocking down the two P. tetraurelia genes encoding UPF1, a protein that is crucial in NMD, we show that the intrinsic efficiency of splicing varies widely among introns and that NMD activity can significantly reduce the fraction of unspliced mRNAs. The results suggest that, independently of alternative splicing, species with large intron numbers universally rely on NMD to compensate for suboptimal splicing efficiency and accuracy. 相似文献
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The control of cell division by tension or diffusion 总被引:7,自引:0,他引:7
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Becker T Franckenberg S Wickles S Shoemaker CJ Anger AM Armache JP Sieber H Ungewickell C Berninghausen O Daberkow I Karcher A Thomm M Hopfner KP Green R Beckmann R 《Nature》2012,482(7386):501-506
Ribosome-driven protein biosynthesis is comprised of four phases: initiation, elongation, termination and recycling. In bacteria, ribosome recycling requires ribosome recycling factor and elongation factor G, and several structures of bacterial recycling complexes have been determined. In the eukaryotic and archaeal kingdoms, however, recycling involves the ABC-type ATPase ABCE1 and little is known about its structural basis. Here we present cryo-electron microscopy reconstructions of eukaryotic and archaeal ribosome recycling complexes containing ABCE1 and the termination factor paralogue Pelota. These structures reveal the overall binding mode of ABCE1 to be similar to canonical translation factors. Moreover, the iron-sulphur cluster domain of ABCE1 interacts with and stabilizes Pelota in a conformation that reaches towards the peptidyl transferase centre, thus explaining how ABCE1 may stimulate peptide-release activity of canonical termination factors. Using the mechanochemical properties of ABCE1, a conserved mechanism in archaea and eukaryotes is suggested that couples translation termination to recycling, and eventually to re-initiation. 相似文献
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李莹 《辽宁师范大学学报(自然科学版)》2010,33(4)
氨基酸序列和基因结构的系统发育分析表明,上游刺激因子家族usf1和usf2基因的产生是基因复制的结果,同时,usf1和usf2的内含子位置以及插入相位分析揭示在不同进化地位的物种中,可独立地发生内含子的插入或删除,因此,看似同源的内含子不一定是同源的,这说明在以内含子为基础进行同源性分析时应谨慎.与低等动物相比,脊椎动物中的usf基因序列高度相似,对比usf1和usf2的各个选择性剪接变体发现,二者的剪接模式都很保守,而新的变体是由点突变或内含子中额外序列的插入造成的.另外,以前的研究均认为所有usf中均有亮氨酸拉链,然而本研究发现,该结构域是新近插入到该蛋白家族中的. 相似文献
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The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells 总被引:75,自引:0,他引:75
Several glycoproteins that control blood-cell production and function have been purified and sequenced. The four colony-stimulating factors interact in a complex way to regulate the differentiation and maturation of the granulocyte and macrophage lineages and have potential applications for the clinical manipulation of blood-cell production. 相似文献
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Molecular basis of triclosan activity 总被引:19,自引:0,他引:19
Levy CW Roujeinikova A Sedelnikova S Baker PJ Stuitje AR Slabas AR Rice DW Rafferty JB 《Nature》1999,398(6726):383-384