Thyroxine administration and the uptake of amino acids by liver cell nucleolus,nucleus and cytoplasm,and by other cell types

Résumé L'administration de thyroxine cause une chute de l'incorporation de la phénylalanine-H³ et du tryptophane-H³ par divers organes, excepté le foie. Le cytoplasme et les noyaux des hépatocytes ont presenté une plus grande concentration de substance injectée.

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This investigation was supported by grants from Fundaçao de Amparo à Pesquisa do Estado de São Paulo, Rockefeller Foundation, and Conselho Nacional de Pesquisas.

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The help of Profs.L. C. U. Junqueira andC. P. Leblond as well as the technical assistance of MissE. Freymüller are acknowledged.     

Sterols of the brine shrimp,Artemia salina,from Mono Kake,California

Zusammenfassung Artemia salina vom Mono-See, Kalifornien, U.S.A., enhält Cholesterin und Cholestanol als ihr hauptsächlichstes Sterin. Diese Zusammensetzung ist ähnlich wie die jenige von im Laboratorium erzeugten Salz-Krabben und zwar trotzdem das Wasser des Mono-Sees ein pH von 9.6 und einen Salzgehalt von 2.23M hat¹⁶.

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Acknowledgment. This work was supported, in part, by a grant from the Long Beach (California) Heart Association.     

Über Peptidsynthesen,XLIII. Darstellung einiger Oxytocin-Analoga

Summary Four new analogues of oxytocin, i.e. Phe²-Ser⁴-Ileu⁸-oxytocin, Phe³-Ser⁴-Ileu⁸-oxytocin, Gly⁴-Ileu⁸-oxytocin and Phe²-Val³-oxytocin have been synthesized and their biological activities compared with those of oxytocin (Syntocinon®).

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XLII. Mitt.:E. Schröder, Justus Liebigs Annln Chem., im Druck.     

Über Peptidsynthesen,XLIV. Synthese von Ser4-Glu(NH2)8-Oxytocin (Glumitocin)

Summary Ser⁴-Glu(NH₂)⁸-Oxytocin has been synthesized. The identity of the synthetic compound with the neurohypophysal hormone (Glumitocin) recently isolated from species of cartilaginous is demonstrated.

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Über Peptidsynthesen XLIII. Mitteilung,E. Klieger, Experientia23, 620 (1967).     

Rate of uptake of75Se,as selenourea-75Se,in rats in vivo

Zusammenfassung Die Geschwindigkeit der Verteilung und Fixierung des Selenharnstoff-⁷⁵Se wurde in diversen Rattenorganen in vivo und bei Stoffwechselzeiten von 6 h bis zu 14 Tagen untersucht. Die Selenharnstoffmengen varierten zwischen 0,4 und 3,0 mg pro Tier.

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The authors wish to thank Dr. H.Hope(Kjemisk Institute, Universitet i Oslo, Norway), for supplying the first selenourea used in these experiments.     

Bazzanenol,a new sesquiterpene alcohol having a skeleton of Bicyclo[5.3.1] undecane system from hepaticae,Bazzania pompeana (Lac.) Mitt

Zusammenfassung Isolierung und Strukturaufklärung eines neuen Sesquiterpenalkohols ausBazzania pompeana (Lac.) Mitt.

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Studies on chemical constituents from Hepaticae, Part III: S.Hayashi, A.Matsuo and T.Matsuura, Tetrahedron Letters,1969, 1599 and ref.² are regarded as Part I and II.     

Constituants amers deBrucea amarissima structures des brucéines A,B et C

Summary Evidence is presented for the structures (II a), (II b) and (II c) for the bruceines A, B and C, the bitter principles isolated from the seeds ofBrucea amarissima.

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18ème Communication sur les constituants amers des Simarubacées; 17ème Communication, voir².     

The visual response of the purple shore crab,Hemigrapsus nudus,to ionizing and non-ionizing radiations

Zusammenfassung Im Krabbenauge vonHemigrapsus nudus entstehen elektroretinographische Reaktionen (ERG) mit sichtbarem Licht und Röntgenstrahlung, die andeuten, dass dieselben Rhodopsin-Erregunsprozesse mit beiden Strahlungsarten stattfinden. Nach⁹⁰Sr--Strahlung wird angenommen, dass Cerenkov-Effekt- und induzierte Fluoreszenz-Lichterzeugung die-ERG-Reaktion deutlich beeinflussen.

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This research was conducted under a grant from the Environmental Control Administration, CPEHS, U.S. Public Health Service No. EC00119.

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Public Health Service Radiological Health Fellowship No. 97996-06-69.     

Zur Biogenese des Xanthocillins,II1: Die Herkunft des Stickstoffs der Isonitril-Gruppen

Summary The incorporation of tyrosine-2-¹⁴C-¹⁵N into xanthocillin X (I) byPenicillium notatum Westling has been investigated showing that nitrogen of the isocyano groups originates from tyrosine, which is incorporated as C₆-C₂-N-unit.

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1. Mitteilung:H. Achenbach undH. Grisebach, Z. Naturforsch.20b, 137 (1965).     

Effets d'un inhibiteur béta-adrénergique,l'aténolol,sur l'activité efférente du nerf rénal chez le lapin

Summary Postganglionic sympathetic nerve activity (renal nerve) decreased significantly during i.v. infusion of a beta-adrenergic blocking drug, atenolol, in anesthetized rabbits. This phenomenon, at least in part reflex in nature, may contribute to the hypotensive effect of atenolol.

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Travail réalisé dans le cadre d'un contrat INSERM, ATP n^o 15.75.38.     

Tryptophan,precursor of tropic acid inDatura stramonium

Zusammenfassung Verfütterung von Tryptophan-3-C¹⁴ anDatura Stramonium führt zur Bildung von radioaktiver Tropinsäure, deren gesamte Radioaktivität auf die Carboxylgruppe beschränkt ist, der zu erwartenden Stelle bei direkter Umwandlung des Tryptophans unter Verlust des Stickstoffes und der zwei endständigen Kohlenstoffatome.

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This study was supported by grants from the Purdue Research Foundation and reported at the AAAS meeting, Chicago, December 1959.     

Myofibrillar ATPase activities of red and white myotomal muscles of marine fish

Zusammenfassung Die Ca⁺⁺-und nicht-Ca⁺⁺-abhängige ATPase-Aktivität von isolierten Myofibrillen der roten und weissen Muskeln von drei Meerfischen wurde gemessen und festgestellt, dass die weissen Muskeln eine höhere Aktivität besitzen.

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I. A. Johnston was in receipt of a Science Research Council Research Studentship.

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This work was also supported by a Natural Environment Research Council grant to Dr.G. Goldspink.     

Komplex-Stabilität und tuberkulostatische Aktivität einiger 8-Oxychinolinderivate

Summary Based on polarographic viz. spectrophotometric determinations of the stabilities of several Cu⁺⁺- and Co⁺⁺⁺ hydroxyquinolin complexes it has been shown that a correlation exists between the quotient of complex-stabilitiesK _Co ⁺⁺⁺ /K _Cu ⁺⁺ and antitubercular activity (cf. table and graph). This supports the hypothesis that the 8-hydroxyquinolin derivatives and analogues act by competitive antagonism; the Cu⁺⁺-hydroxy-quinolates are able to replace Co in a prosthetic group of Mycobacterium-enzyme with Cu.

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Vorgetragen an der Organisch-Chemischen Konferenz des Vereines ungarischer Chemiker, 27. September 1953.

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III. Mitteilung: Acta chim. Hungarica (im Druck).     

Effect ofd,l-glyceraldehyde on bacterial cells metabolism

Riassunto In aerobiosi lad-l-gliceraldeide a notevoli concentrazioni ha una lievissima azione inibente sulla ossidazione del glucosio e sulla incorporazione di leucina-C¹⁴. In condizioni di anaerobiosi invece lad-l-gliceraldeide in concentrazioni medie inibisce notevolmente sia la glicolisi che la incorporazione di leucina-C¹⁴.

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This work was carried out with the help of Consiglio Nazionale delle Ricerche (CNR).     

Inhibition of steroidΔ 4 reductase by heparin: Studies with desoxycorticosterone,progesterone, androstenedione and testosterone

Zusammenfassung Heparin hemmt die Reduktion der Doppelbindung in 4-Stellung des Rings A einer Reihe von C-11-desoxy, ⁴-4-keto-Steroiden in der Rattenleber. Es scheint, dass Heparin mit NADPH um das Steroid-reduktase-Apoenzym konkurriert.

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This work was supported by grant No. AM-09151 from The National Institutes of Health, U.S.P.H.S.     

CMR spectral analysis of tetrahydrocannabinol and its isomers

Zusammenfassung Die¹³C-NMR-Spektren des Tetrahydrocannabinols und seiner Isomeren wurden aufgenommen und vollständig analysiert.

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Carbon-13 Nuclear Magnetic Resonance Spectroscopy of Naturally Occurring Substances. IX. For the preceding article seeE. Wenkert, C.-J. Chang, D. W. Cochran andR. Pellicciari, Experientia28, paper No. 1099 (1972).

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U.S. Public Health Service predoctoral fellow, 1967–1971.

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U.S. Public Health Service predoctoral fellow, 1969–1972.     

Synthetic peptides related to eledoisin

Riassunto Vengono descritte le proprietà di una serie di peptidi sintetici affini per struttura ed attività all'eledoisina

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Part IV, for part III see³.     

Synthetic peptides related to eledoisin

Zusammenfassung Die Eigenschaften einer Serie von synthetischen Peptiden, die mit Eledoisin strukturell und wirkungsmässig verwandt sind, werden beschrieben.

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Part II. See⁴ for part I.     

Arginine-vasopressin,lysine-vasopressin,and oxytocin,C14-labeled in the glycine residue

Zusammenfassung Die Synthese von Arginin-Vasopressin, Lysin-Vasopressin und Oxytocin, deren Glycinrest eine¹⁴C-Markierung trägt, wird mit Hilfe der Festkörpermethode nachMerrifield beschrieben.

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Supported by National Institutes of Health grants No. AM-13567 and No. AM-10080 and the Atomic Energy Commission.

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Abbreviations follow the rules of the IUPAC-IUB Commission on Biochemical Nomenclature in Biochemistry5, 2485 (1966). All optically-active amino acids are ofl-configuration. The following additional abbreviations were used: N-hydroxysuccinimide ester (OSu), ethanol (EtOH), methanol (MeOH), acetic acid (AcOH),n-butanol (n-BuOH), pyridine (Pyr) and N,N-dicyclohexylcarbodiimide (DCCI). Protected peptides and hormones were visualized on thinlayer plates according to the procedure byH. Zahn andE. Rexroth, Z. analyt. Chem.148, 181 (1955). The biological activities of the hormones were measured against the U.S.P. Posterior Pituitary Reference Standard; the four-point design was used for these bioassays and standard errors were calculated according to the method ofC. I. Bliss,The Statistics of Bioassay (Academic Press, New York, N.Y. 1952).

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Acknowledgments. The authors wish to thank Mr.D. Schlesinger for some of the amino acid derivatives used, and MissM. Wahrenburg and Mrs.A. Silverman for bioassays.     

Zum Proliferations-Stoffwechsel der Rattenleber nach Teilhepatektomie. Autoradiographische Untersuchungen mit3H-Cytidin,-Phenylalanin und -Thymidin

Summary During the first wave of parenchymal liver regeneration in adult rats after partial hepatectomy, the cellular synthesis and migration of RNA and the metabolism of protein were studied by autoradiography following an injection of³H-cytidine or³H-l-phenylalanine and double injections of 1 of these precursors +³H-thymidine. The following results were obtained: the synthesis and migration of RNA and the metabolism of protein are enhanced under these conditions of proliferation. In spite of this, the relation of metabolic activity in nucleolus, karyoplasm and cytoplasm remains constant. By double injection techniques it is proved that no differences exist in migration of RNA into the cytoplasm and cytoplasmic protein synthesis between cells with or without DNA synthesizing nuclei.

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Mit Unterstützung der Deutschen Forschungsgemeinschaft.