新生儿窒息免疫球蛋白及补体变化及临床意义

目的探讨新生儿窒息免疫球蛋白及补体的变化与临床的关系。方法通过对窒息组与对照组生后24h及生后第7d测血清免疫球蛋白及补体进行对比分析。结果新生儿轻度窒息患儿的血清免疫球蛋白及补体降低,与对照组比较无显著性差异（P〉0．05））,重度窒息患儿血清免疫球蛋白及补体明显降低,与对照组比较有显著性差异（P〈0．05）。结论新生儿窒息时血清免疫球蛋白及补体变化与窒息程度密切相关。     

胎膜早破对新生儿脐血免疫球蛋白及补体的影响

目的:研究胎膜早破时新生儿脐血免疫球蛋白、补体的变化规律。方法:应用速率透射比浊法检测79例新生儿脐血IgG、IgA、IgM和补体C3、C4水平,追踪新生儿出生1周内感染发生的情况,其中有胎膜早破史的研究组38例,无胎膜早破史的对照组41例。结果:胎膜早破组脐血IgA(0.16±0.12)g/L,对照组(0.06±0.03)g/L,(P<0.01);胎膜早破组IgM(0.24±0.15)g/L,对照组(0.16±0.03)g/L,(P<0.01),差异有统计学意义;脐血IgG水平无明显变化;脐血IgA浓度在胎膜早破72h为0.234±0.156)g/L,较胎膜早破<12h的0.091±0.047g/L明显增加,差异有统计学意义(P<0.05);脐血补体C3(0.76±0.35)g/L,对照组(0.93±0.21)g/L,(P<0.05),C4(0.16±0.09)g/L,对照组0.20±0.05g/L,(P<0.05),研究组明显低于对照组,差异有统计学意义。结论:有胎膜早破史的新生儿,脐血免疫球蛋白IgA、IgM浓度升高,IgG不受胎膜早破的影响,脐血补体C3、C4水平下降。脐血IgA、IgM及补体C3、C4均能反映胎膜早破个体合并宫内感染。     

新生儿窒息后血清总胆汁酸变化的临床意义

目的 探讨新生儿窒息血清总胆汁酸（TBA）变化的临床意义。方法 窒息组共40例新生儿窒息患者,其中轻度窒息18例,重度窒息22例;正常对照组30例为健康新生儿。采用酶比色法对窒息组和正常对照组新生儿进行血清TBA测定。结果 窒息组血清TBA明显升高,与正常对照组相比差异有显著性（P〈0．01）。窒息组血清TBA与窒息程度有关,重度窒息组TBA高于轻度窒息组（P〈0．01）。结论 血清TBA可作为新生儿窒息后肝脏受损的一个重要监测指标,可反映窒息程度。     

新生儿窒息的抢救及护理

通过对１３７例新生儿窒息的抢救及护理，使新生儿窒息的存活率达９７．８％，并分析了新生儿窒息发生的原因，提出了新生儿窒息如何进行抢救及护理。     

健身气功易筋经对血清免疫球蛋白及补体活性的影响

为了研究健身气功易筋经对老年人机体免疫分子免疫球蛋白与补体活性的影响,以30名健康老年为研究对象,随机分为易筋经组和对照组各15人,经过6个月的健身气功易筋经锻炼分别测定实验前后血清IgG、IgM、IgA含量及C3、C4含量．结果显示血清IgG、C3、C4含量与对照组相比增高,且具有显著性差异（P〈0．05或P〈0．01）,而IgM、IgA含量与对照组相比无明显变化．认为长期坚持健身气功易筋经锻炼能提高老年人免疫球蛋白和补体含量,提高机体免疫功能．     

新生儿窒息后24小时血钠血钙变化

本文对本院儿科１９９４年１月至１９９５年６月收治的１２３例新生儿窒息患儿生后２４小时的血钠血钙变化，以及合并脑损害患儿的血钠血钙变化作了前瞻性研究。本文还对新生儿窒息后发生低钠血症，低钙血的机理进行了探讨。     

在窒息新生儿中开展行为神经评分的临床意义

新生儿窒息是围产期常见的疾病，也是造成小儿担神运动发育异常的主要原因之一。随着围产医学的不断发展，对窒息新生儿的神经行为及智能发育有过许多报导，此类婴儿常伴有许多合并症，出现行为异常及智能低下。对此，我们于1998年5月以前，对我院在1994年月一IN7年5月出生的窒息新生儿中对其中95例进行了行为评分及智能随访。新生儿行为评分是1984年由鲍秀兰教授所创立的。采用B。lion方法与法国的AllllelTison方法结合，创立了中国20项新生儿行为神经测定评分法（Ner）llatalBehavioralNedscalAssessment简称NBNA法），检查方法包括…     

新生儿窒息手术室抢救护理

新生儿窒息是胎儿因缺氧发生宫内窘迫以致出生后无呼吸或呼吸抑制者。情况紧急必须迅速有效抢救才能挽救生命，减少并发症。我院手术室1995年1月至2000年6月共抢救新生儿窒息26例，均获成功。 1 临床资料 依照Apgar评分标准分重度窒息1-4分，8例；轻度窒息5-7分，18例. Apgar评分标准：重度窒息表现为皮肤苍白，呼吸微弱或无呼吸，肌张力松驰，心率多在100次/分以下；经度窒息表现为全身皮肤青紫，呼吸不规则，心率正常。 2 手术室抢救及护理 2.1 建立通畅的气道。首先应迅速、有效清理呼吸道中的羊水、胎粪及其它分泌物。器械护士在胎…     

1960年以来太湖水位变化特征及影响因素分析

以太湖为研究对象,综合采用Mann-Kendall突变检验和Morlet小波分析等方法,分析太湖1960—2018年水位数据,阐明太湖水文特征变化及其影响因素．结果表明:1960—2018年间太湖水位整体呈现缓慢上升趋势,极值水位波动幅度较强;年内水位受降雨分配的影响呈单峰型变化,汛期尤为明显;水位周期性显示稳定的时间尺度是9 a,变化强烈的时间尺度分别是22和28 a;气候变化和人类活动共同影响了太湖水位的变化,2000年前太湖水位对降水的响应十分敏感,而2000年后太湖水位受人为调控而趋于稳定;合理范围内的水位波动对整个流域的水资源调配和太湖的生态水文特征有重要影响,科学的水利工程调控有利于太湖湖泊生态系统的健康发展．研究结果可为太湖水情调控和湖泊生态系统管理提供理论参考和决策依据．      

Biodiversity of Early-Middle Ordovician acritarchs and sea level changes in South China

Acritarchs are organic-walled cysts of unicellular pro- tists that cannot be assigned to any known group of or- ganisms. Most acritarchs are probably the resting cysts of marine eukaryotic phytoplankton. Because of their small size, abundance and diversity, as well as widespread distri- bution, acritarchs are very useful in biostratigraphic cor- relation, as well as paleobiogeographic and paleoenviron- mental studies. Furthermore, they represent the fossil re- cord of the base of the marine fo…     

Structure of C3b reveals conformational changes that underlie complement activity

Resistance to infection and clearance of cell debris in mammals depend on the activation of the complement system, which is an important component of innate and adaptive immunity. Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces to amplify complement response, label cells for phagocytosis and stimulate the adaptive immune response. C3b consists of 1,560 amino-acid residues and has 12 domains. It binds various proteins and receptors to effect its functions. However, it is not known how C3 changes its conformation into C3b and thereby exposes its many binding sites. Here we present the crystal structure at 4-A resolution of the activated complement protein C3b and describe the conformational rearrangements of the 12 domains that take place upon proteolytic activation. In the activated form the thioester is fully exposed for covalent attachment to target surfaces and is more than 85 A away from the buried site in native C3 (ref. 5). Marked domain rearrangements in the alpha-chain present an altered molecular surface, exposing hidden and cryptic sites that are consistent with known putative binding sites of factor B and several complement regulators. The structural data indicate that the large conformational changes in the proteolytic activation and regulation of C3 take place mainly in the first conversion step, from C3 to C3b. These insights are important for the development of strategies to treat immune disorders that involve complement-mediated inflammation.     

Heinrich layer in Antarctic marine sediments and its significance to global changes

Results of grain size analysis and rock magnetic measurements of core NP95-1 from Prydz Bay, Antarctica revealed two series of ice-rafted detritus layers, which correspond to cold climatic events, Younger Dryas and Heinrich event 1, occurring at about 11.7-10.3 and 14.3-13.6 kaB.P. respectively. Studies also show that the sequence of paleoclimatic changes in Antarctica can be correlated with that in other parts of the world, and that the millennia1 climate of the earth could change synchronously and globally. In addition, magnetic fabric analysis also shows a close relationship between paleoclimatic change and ocean circulation re-assemblage.     

珠江三角洲洪水位重现期变化研究

针对近年来珠江三角洲大洪水频频发生,洪水重现期发生变化的情况,它采用GEV分布模型对珠江三角洲35个潮位站50年左右的极端高水位值进行频率分析,在此基础上将50年左右的时间序列分成若干时间段,通过Monte-Carlo模拟随机方法在每个时间段里建立概率密度函数曲线以及水位与洪水重现期关系的函数曲线,进一步研究洪水重现期随时间的变化规律并分析其机理。结果表明：珠江三角洲中部腹地洪水重现期水位明显有增大的趋势,而上游以及口门区变化则不大,产生这种变化的一个重要原因是上部地区大规模的挖沙活动对河道及周边环境带来负面影响。     

Interferometric radar measurements of water level changes on the Amazon flood plain

Measurements of water levels in the main channels of rivers, upland tributaries and floodplain lakes are necessary for understanding flooding hazards, methane production, sediment transport and nutrient exchange. But most remote river basins have only a few gauging stations and these tend to be restricted to large river channels. Although radar remote sensing techniques using interferometric phase measurements have the potential to greatly improve spatial sampling, the phase is temporally incoherent over open water and has therefore not been used to determine water levels. Here we use interferometric synthetic aperture radar (SAR) data, acquired over the central Amazon by the Space Shuttle imaging radar mission, to measure subtle water level changes in an area of flooded vegetation on the Amazon flood plain. The technique makes use of the fact that flooded forests and floodplain lakes with emergent shrubs permit radar double-bounce returns from water and vegetation surfaces, thus allowing coherence to be maintained. Our interferometric phase observations show decreases in water levels of 7-11 cm per day for tributaries and lakes within approximately 20 km of a main channel and 2-5 cm per day at distances of approximately 80 km. Proximal floodplain observations are in close agreement with main-channel gauge records, indicating a rapid response of the flood plain to decreases in river stage. With additional data from future satellite missions, the technique described here should provide direct observations important for understanding flood dynamics and hydrologic exchange between rivers and flood plains.     

ST段改变在冠心病诊断中临床意义的评价

目的：评估心电图ST段改变在冠心病诊断中的意义。方法：以冠状动脉造影为金标准,与心电图ST段改变作比较,计算心电图的灵敏度和特异度等指标。结果：灵敏度53.85%;特异度84.21%;符合率61.97%;阳性预测值90.32%;阴性预测值40.00%。结论：心电图ST段改变在冠心病诊断中灵敏度太低,特异度尚可。