Effect of chronic treatment with mescaline upon tissue levels of the drug

Zusammenfassung Bei chronisch behandelten Ratten war die Mescalin-Konzentration in Gehirn und Leber niedriger als bei akut behandelten Tieren. Die Hemmung der Monoaminooxydase durch Vorbehandlung mit Pargylin erhöhte signifikant die Mescalinmenge in der Leber. Ferner liessen die Untersuchungen den Schluss zu, dass die MAO oder andere Aminooxydasen, die durch Pargylin gehemmt werden, nicht die Hauptrolle bei den beobachteten Veränderungen in den Gewebekonzentrationen spielen.

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Acknowledgments. This work was supported in part by Research Grant No. 15406 from the National Institute of Mental Health. Dr. Sethy was the recipient of a Henry C. and Bertha H. Buswell Research Fellowship from the State University of New York at Buffalo.     

Effect of chronic alloxan diabetes and insulin treatment on adipose tissue lipid composition of rats

Summary Decreased content of the adipose tissue lipids was observed in chronic alloxan diabetic rats and was restored to normal with insulin treatment. Prolonged insulin treatment in normal rats also resulted in increase of the lipid content of the adipose tissue.     

Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment

Recent reports describe successful treatment using copper chelation therapy in neurodegenerative animal models. However, the success claimed for chelation therapy in neurodegenerative diseases is still rather controversial. To acquire new information on copper metabolism/homeostasis, we utilized cuprizone, a very sensitive and selective copper-chelating agent with well-known neurotoxic properties, as a relevant chemical model in mice. Upon cuprizone treatment, mice developed a pronounced astrocytosis, with brain oedema and spongiosis characterised by vacuolisations of the neuropil predominantly in the white matter. In addition, cuprizone treatment severely altered copper and zinc homeostasis in the central nervous system (CNS) as well as in all other tissues examined, with increasing metal ion concentrations particularly in the CNS. Concomitant with this increase in the Cu and Zn concentration in the brain, metallothionein-I and -II were also highly immunoreactive in astrocyte, consistent with the astrocytosis and demyelination observed in our and other laboratories.Received 23 February 2005; received after revision 3 May 2005; accepted 13 May 2005     

Effects of chronic treatment with ACTH on the intracellular levels of cyclic-AMP and cyclic-GMP in the rat adrenal cortex

Summary The effects of chronic ACTH treatment on the increase in the intracellular concentration of cyclic-AMP and cyclic-GMP acutely elicited by ACTH in the rat adrenal cortex were investigated. The results are consistent with the hypothesis that chronic ACTH treatment stimulates a) the de novo synthesis of adenylate- and guanylate-cyclase or b) the synthesis of new specific membrane receptors for ACTH.Part of this work was presented at the 3rd International Conference on Cyclic Nucleotides, July 1977, New Orleans, Abstr. Book, p. 79.     

Effects of chronic treatment with ACTH on the intracellular levels of cyclic-AMP and cyclic-GMP in the rat adrenal cortex.

The effects of chronic ACTH treatment on the increase in the intracellular concentration of cyclic-AMP and cyclic-GMP acutely elicited by ACTH in the rat adrenal cortex were investigated. The results are consistent with the hypothesis that chronic ACTH treatment stimulates a) the de novo synthesis of adenylate- and guanylate-cyclase or b) the synthesis of new specific membrane receptors for ACTH.     

Influence of hormones and X-Rays upon the tissue mast cell

Résumé Diverses hormones sexuelles et pituitaires étaient sans effet sur les labrocytes du mésentère et de la peau du rat. L'irradiation partielle du rat et du hamster provoquait des altérations signifiques dans les tissus irradiés mais était sans effet dans les tissus non irradiés.

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This work was performed under auspices of U.S. Atomic Energy Commission.     

Effect of experimental chronic renal failure upon the production of urea,as measured by the liver arginase activity in rats

Summary A significant diminution in liver arginase activity of chronic renal failure uremic rats is described, thus implying that the experimental finding of an increased urea production is not due to a depressed arginase activity.This work was supported by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico do Brasil's Grants. —Acknowledgments. We are indebted to Mr D'Arrochela Lobo for technical assistance, Mr Celso Chiarin for the statistical review and Dr C.E. Tosta and Dr Linda Caldas for helpful advice.     

The inhibitory effects of a dermal extract upon granulation tissue

Cellular and Molecular Life Sciences - Injection of a water-soluble dermal extract into adult rats resulted in depression of DNA synthesis in granulation tissue at 3 different sites of injury, but...     

Effect of acute administration of delta 1-tetrahydrocannabinol on beta-endorphin levels in plasma and brain tissue of the rat

Acute treatment with delta 1-tetrahydrocannabinol (delta 1-THC) elevated the concentration of beta-endorphin-like immunoreactivity (beta-ELIR) in plasma and in the hypothalamus, but not in the hippocampus of rats habituated to the injection procedure. These effects were not obtained with the psychotropically inert analog of delta 1-THC, cannabidiol. In animals that had not been habituated to the injection procedure, placebo treatment induced a decrease in hippocampal beta-ELIR.     

The influence of chlorothiazide and tolbutamide upon intestinal serotonin levels in the sprague-dawley rat

Zusammenfassung Der Serotoningehalt der Schleimhaut im obern Duodenumteil, im mittleren Jejunum, im Ileumendteil und im Appendix von Sprague-Dawley Charles River Rattenmännchen wurde ohne Vorbehandlung und mit Chlorothiazid- und Tolbutamidvorbehandlung spektrophotofluorimetrisch bestimmt. Die Serotoningehalte für die 3 Gruppen vergleichbarer Gewebe waren ähnlich, was zeigt, dass die früher beschriebene Erhöhung des Serotoningehaltes der Schleimhaut nach Sulfamerazinvorbehandlung wahrscheinlich nicht mit einer unspezifischen Wirkung des Sulfonamidteils verbunden ist.

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This study was supported in part by an award from the National Science Foundation toJ. H. Thompson, M.D., M.R.C.P.I., Department of Pharmacology, U.C.L.A. School of Medicine, Los Angeles, California 90024.     

Effect of catatoxic steroids upon established morbid changes

Résumé Chez les rats, une résistance à la digitoxine et à l'indométhacine peut être rapidement induite par des stéroïdes catatoxiques tel que la spironolactone ou la pregnénolone-16-carbonitrilée (PCN). En fait, la PCN peut encore sauver la vie de l'animal en dépit d'un traitement utilisant des doses normalement mortelles de digitoxine ou d'indométhacine, même si le traitement par ces stéroïdes n'est commencé qu'après que des signes d'intoxication sont déjà devenus manifestes. Evidemment, les stéroïdes catatoxiques ne sont pas seulement des agents prophylactiques, ils peuvent également guérir des lésions morbides déjà établies.     

Liver vitamin A stores in chronic alcoholism in rats: Effect of propylthiouracil treatment

Summary Administration of alcohol to rats through drinking water for 8 weeks produced a significant decrease in the liver vitamin A stores without causing any change in the plasma vitamin A levels. Treatment of the alcoholic rats with propylthiouracil for 2 weeks restored the liver vitamin A reserves to control levels.     

Effect of experimental allergic encephalomyelitis γ-globulin upon the electrical activity of the brain

Zusammenfassung Die direkte Wirkung eines-Globulin-Präparates aus Kaninchenserum (Injektion in laterale Hirnkammer des Kaninchens) auf die experimentelle allergische Encephylomyelitis wurde dargestellt und elektroencephalographisch eine Inaktivierung verschiedener Hirnregionen festgestellt.