Tolerance to,and symmetrical cross-tolerance between,cannabionol and 295-1295-1295-1

Summary Tolerance to, and symmetrical cross-tolerance between, cannabinol and ⁹-tetrahydrocannabinnol (THC) occurs in rabbits which uniquely exhibit behavioral convulsions with THC.This research was supported by funds (grant No.DA01448) and cannabinoids from the National Institute on Drug Abuse.     

Baroreceptor and sympathetic responses to acebutolol,a 646-1646-1646-1agent,in rabbits

Summary Baroreceptor activity was increased after i.v. infusion of acebutolol in rabbits with an intact circulation, and in rabbits with a total cardiopulmonary by-pass. In rabbits with an intact circulation, renal nerve activity was reduced.We wish to thank Mrs H. Bodard and Mrs F. Raimbault for their technical collaboration and Specia Laboratories for supplying acebutolol. This work was supported by a grant from INSERM (ATP No. 15.75.38).     

Zimmermann reaction of 3-, 6- and 20-oxosteroids

Zusammenfassung Die Farbreaktion nach Zimmermann von Steroiden mit 3-, 6- oder 20-Oxogruppen wurde spektrophotometrisch untersucht. Während 6- und 20-Oxogruppen sich gegenseitig nicht störten, war eine Beeinflussung zwischen den 3- und 6-Oxogruppen zu beobachten.     

A comparison of the pharmacological activity in man of intravenously administered 1368-11368-11368-1, cannabinol,and cannabidiol

Resumen Se hizo un estudio comparativo de la actividad del ⁹-tetrahidrocannabinol, cannabinol, y cannabidiol en producir efectos similares a la marihuana cuando son inyectados i.v. a humanos. Estas substancias son los componentes predominantes de la marihuana o del hashish. Se encontro que a las dosis inyectados cannabidiol no tiene ninguna potencia, y que cannabinol es capaz de producir efectos tipicos de la marihuana, aunque a dosis varias veces mas grandes que las del ⁹-tetrahidrocannabinol.     

Pharmacological studies of a new analgesic,dl-erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride,in experimental animals

Summary dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals.     

Pharmacological studies of a new analgesic, dl-erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride, in experimental animals.

dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals.